The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.
Cellular and molecular aspects of ovarian follicle ageing
Abstract
It is well established that age-related decline of the biological capacity of a woman to reproduce is primarily related to the poor developmental potential of her gametes. This renders female ageing the most significant determinant of success in IVF. Starting with a reference picture of the main molecular and cellular failures of aged oocytes, granulosa cells and follicular microenvironment, this review focuses on age-related biochemical mechanisms underlying these changes. According to the most relevant concept of ageing, age-associated malfuction results from physiological accumulation of irreparable damage to biomolecules as an unavoidable side effect of normal metabolism. More than a decade after the free radical theory of ovarian ageing, biological and clinical research supporting the involvement of oxidative injuries in follicle ageing is discussed. Looking for the aetiology of oxidative stress, we consider the effect of ageing on ovarian and follicular vascularization. Then, we propose a potential role of advanced glycation end-products known to be involved in the physiological ageing of most tissues and organs. We conclude that future investigation of age-related molecular damage in the different ovarian components will be imperative in order to evaluate the possibility to save or rescue the developmental potential of aged oocytes.
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Cites
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Cited by
Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health
Dumesic, D. A., Meldrum, D. R., Katz-Jaffe, M. G., Krisher, R. L., & Schoolcraft, W. B. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.11.015 · Cited by 640
Ovarian ageing: the role of mitochondria in oocytes and follicles
May-Panloup, P., Boucret, L., Chao de la Barca, J.-M., Desquiret-Dumas, V., Ferré-L'Hotellier, V., Morinière, C., Descamps, P., Procaccio, V., & Reynier, P. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw028 · Cited by 577
Dietary Advanced Glycation End Products and Aging
Luevano-Contreras, C., & Chapman-Novakofski, K. (2010) · Nutrients · doi:10.3390/nu2121247 · Cited by 396
Tatone, C., Di Emidio, G., Barbonetti, A., Carta, G., Luciano, A. M., Falone, S., & Amicarelli, F. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy003 · Cited by 294
Self-citationResveratrol protects against age-associated infertility in mice
Liu, M., Yin, Y., Ye, X., Zeng, M., Zhao, Q., Keefe, D. L., & Liu, L. (2013) · Human Reproduction · doi:10.1093/humrep/des437 · Cited by 288
Metadata
- Authors
- Tatone, C., Amicarelli, F., Carbone, M. C., Monteleone, P., Caserta, D., Marci, R., Artini, P. G., Piomboni, P., & Focarelli, R.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-01-31
- Volume
- 14
- Issue
- 2
- Pages
- 131-142
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2124411067
- Cited by
- 405
- References
- 149
- FWCI
- 15.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tatone, C., Amicarelli, F., Carbone, M. C., Monteleone, P., Caserta, D., Marci, R., Artini, P. G., Piomboni, P., & Focarelli, R. (2008). Cellular and molecular aspects of ovarian follicle ageing. Human Reproduction Update. https://doi.org/10.1093/humupd/dmm048
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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