Cited by 463Ovarian function and disordersGenetic and Kidney Cyst DiseasesEndometriosis Research and Treatment

An international consortium update: pathophysiology, diagnosis, and treatment of polycystic ovarian syndrome in adolescence

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Ibáñez, Lourdes, Oberfield, Sharon E., Witchel, Selma, Auchus, Richard J., Chang, R. Jeffrey, Codner, Ethel, Dabadghao, Preeti, Darendeliler, Feyza +18 more·2017·Hormone Research in Paediatrics

Abstract

This paper represents an international collaboration of paediatric endocrine and other societies (listed in the Appendix) under the International Consortium of Paediatric Endocrinology (ICPE) aiming to improve worldwide care of adolescent girls with polycystic ovary syndrome (PCOS)1. The manuscript examines pathophysiology and guidelines for the diagnosis and management of PCOS during adolescence. The complex pathophysiology of PCOS involves the interaction of genetic and epigenetic changes, primary ovarian abnormalities, neuroendocrine alterations, and endocrine and metabolic modifiers such as anti-Müllerian hormone, hyperinsulinemia, insulin resistance, adiposity, and adiponectin levels. Appropriate diagnosis of adolescent PCOS should include adequate and careful evaluation of symptoms, such as hirsutism, severe acne, and menstrual irregularities 2 years beyond menarche, and elevated androgen levels. Polycystic ovarian morphology on ultrasound without hyperandrogenism or menstrual irregularities should not be used to diagnose adolescent PCOS. Hyperinsulinemia, insulin resistance, and obesity may be present in adolescents with PCOS, but are not considered to be diagnostic criteria. Treatment of adolescent PCOS should include lifestyle intervention, local therapies, and medications. Insulin sensitizers like metformin and oral contraceptive pills provide short-term benefits on PCOS symptoms. There are limited data on anti-androgens and combined therapies showing additive/synergistic actions for adolescents. Reproductive aspects and transition should be taken into account when managing adolescents.

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Crossref · 10.1159/000479371

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244 of 244 references verified0 citation errors · 0 not checkable

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Authors
Ibáñez, L., Oberfield, S. E., Witchel, S., Auchus, R. J., Chang, R. J., Codner, E., Dabadghao, P., Darendeliler, F., Elbarbary, N. S., Gambineri, A., Garcia Rudaz, C., Hoeger, K. M., López-Bermejo, A., Ong, K., Peña, A. S., Reinehr, T., Santoro, N., Tena-Sempere, M., Tao, R., Yildiz, B. O., Alkhayyat, H., Deeb, A., Joel, D., Horikawa, R., de Zegher, F., & Lee, P. A.
Affiliations
  • Hospital Sant Joan de Déu Barcelona (ES)
  • Morgan Stanley Children's Hospital (US)
  • Children's Hospital of Pittsburgh (US)
  • University of Michigan (US)
  • University of California San Diego (US)
  • Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN)
  • Ain Shams University (EG)
  • University of Bologna (IT)
  • University of Rochester Medicine (US)
  • University of Cambridge (GB)
  • The University of Adelaide (AU)
  • Witten/Herdecke University (DE)
  • Yale University (US)
  • Mafraq Hospital (AE)
  • University of Botswana (BW)
  • National Center For Child Health and Development (JP)
  • Pennsylvania State University (US)
Venue
Hormone Research in Paediatrics
Publisher
S. Karger AG
Published
2017
Volume
88
Issue
6
Pages
371-395
ISSN
  • 1663-2818 (ISSN-L)
  • 1663-2826
OpenAlex
W2770022783
Cited by
463
References
244
Citations by year
2026: 32 · 2025: 46 · 2024: 67 · 2023: 82 · 2022: 65 · 2021: 67 · 2020: 45 · 2019: 40 · 2018: 17 · 2016: 1 · 2012: 1
FWCI
32.35
Type
journal article
Language
en
Open access
Locations
  • Hormone Research in Paediatrics (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
  • Lirias (submittedVersion)
  • Hacettepe University Institutional Repository (hacettepe.edu.tr) (submittedVersion, other-oa)
  • Universidad de Chile (submittedVersion, cc-by-nc-nd)
  • RISalud Institutional Health Repository of Andalucía (submittedVersion, other-oa)
Funders
Medical Research Council (MC_UU_12015/2)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Keywords
polycystic ovary syndrome, adolescent girls, PCOS pathophysiology, PCOS diagnosis, PCOS treatment, hyperinsulinemia, insulin resistance, anti-Müllerian hormone, hyperandrogenism, menstrual irregularity, hirsutism, obesity, metformin, oral contraceptives, androgen receptor antagonists, lifestyle intervention, reproductive transition, PCOS diagnostic criteria
MeSH terms
Adolescent, Congresses as Topic, Female, Humans, Polycystic Ovary Syndrome

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