The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: implications for fertility preservation
Open accessAbstract
BACKGROUND Female cancer patients are offered 'banking' of gametes before starting fertility-threatening cancer therapy. Transplants of fresh and frozen ovarian tissue between healthy fertile and infertile women have demonstrated the utility of the tissue banked for restoration of endocrine and fertility function. Additional methods, like follicle culture and isolated follicle transplantation, are in development. METHODS Specialist reproductive medicine scientists and clinicians with complementary expertise in ovarian tissue culture and transplantation presented relevant published literature in their field of expertise and also unpublished promising data for discussion. As the major aims were to identify the current gaps prohibiting advancement, to share technical experience and to orient new research, contributors were allowed to provide their opinioned expert views on future research. RESULTS Normal healthy children have been born in cancer survivors after orthotopic transplantation of their cryopreserved ovarian tissue. Longevity of the graft might be optimized by using new vitrification techniques and by promoting rapid revascularization of the graft. For the in vitro culture of follicles, a successive battery of culture methods including the use of defined media, growth factors and three-dimensional extracellular matrix support might overcome growth arrest of the follicles. Molecular methods and immunoassay can evaluate stage of maturation and guide adequate differentiation. Large animals, including non-human primates, are essential working models. CONCLUSIONS Experiments on ovarian tissue from non-human primate models and from consenting fertile and infertile patients benefit from a multidisciplinary approach. The new discipline of oncofertility requires professionalization, multidisciplinarity and mobilization of funding for basic and translational research.
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Citations
Cites
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Livebirth after orthotopic transplantation of cryopreserved ovarian tissue
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Self-citationDevelopment in vitro of mouse oocytes from primordial follicles
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Suppression of Ovarian Follicle Activation in Mice by the Transcription Factor Foxo3a
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Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool
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Web-Based Survey of Fertility Issues in Young Women With Breast Cancer
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Cited by
(2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.09.013 · Cited by 753
Metaphase II oocytes from human unilaminar follicles grown in a multi-step culture system
McLaughlin, M., Albertini, D. F., Wallace, W. H. B., Anderson, R. A., & Telfer, E. E. (2018) · MHR: Basic science of reproductive medicine · doi:10.1093/molehr/gay002 · Cited by 317
Self-citation(2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.08.012 · Cited by 269
Desai, N., Ludgin, J., Sharma, R., Anirudh, R. K., & Agarwal, A. (2013) · Clinical Reproductive Medicine and Surgery · doi:10.1007/978-1-4614-6837-0_3 · Cited by 8
Metadata
- Authors
- Smitz, J., Dolmans, M. M., Donnez, J., Fortune, J. E., Hovatta, O., Jewgenow, K., Picton, H. M., Plancha, C., Shea, L. D., Stouffer, R. L., Telfer, E. E., Woodruff, T. K., & Zelinski, M. B.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-02-01
- Volume
- 16
- Issue
- 4
- Pages
- 395-414
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2132086132
- Cited by
- 306
- References
- 99
- FWCI
- 33.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Smitz, J., Dolmans, M. M., Donnez, J., Fortune, J. E., Hovatta, O., Jewgenow, K., Picton, H. M., Plancha, C., Shea, L. D., Stouffer, R. L., Telfer, E. E., Woodruff, T. K., & Zelinski, M. B. (2010). Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: implications for fertility preservation. Human Reproduction Update. https://doi.org/10.1093/humupd/dmp056
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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