The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool
Abstract
In the mammalian ovary, progressive activation of primordial follicles from the dormant pool serves as the source of fertilizable ova. Menopause, or the end of female reproductive life, occurs when the primordial follicle pool is exhausted. However, the molecular mechanisms underlying follicle activation are poorly understood. We provide genetic evidence that in mice lacking PTEN (phosphatase and tensin homolog deleted on chromosome 10) in oocytes, a major negative regulator of phosphatidylinositol 3-kinase (PI3K), the entire primordial follicle pool becomes activated. Subsequently, all primordial follicles become depleted in early adulthood, causing premature ovarian failure (POF). Our results show that the mammalian oocyte serves as the headquarters of programming of follicle activation and that the oocyte PTEN-PI3K pathway governs follicle activation through control of initiation of oocyte growth.
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Cites
The phosphoinositide 3-kinase pathway
Cantley, L. C. (2002) · Science · doi:10.1126/science.296.5573.1655 · Cited by 5,621
Initial and cyclic recruitment of ovarian follicles
McGee, E. A., & Hsueh, A. J. W. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0394 · Cited by 1,771
Cited by
Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Diamanti-Kandarakis, E., Bourguignon, J.-P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., Zoeller, R. T., & Gore, A. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0002 · Cited by 4,585
The ovary: basic biology and clinical implications
Richards, J. S., & Pangas, S. A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41350 · Cited by 561
Genetics of primary ovarian insufficiency: new developments and opportunities
Qin, Y., Jiao, X., Simpson, J. L., & Chen, Z.-J. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv036 · Cited by 554
Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing
Crain, D. A., Janssen, S. J., Edwards, T. M., Heindel, J., Ho, S.-M., Hunt, P., Iguchi, T., Juul, A., McLachlan, J. A., Schwartz, J., et al. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.08.067 · Cited by 465
WWP2 is an E3 ubiquitin ligase for PTEN
Maddika, S., Kavela, S., Rani, N., Palicharla, V. R., Pokorny, J. L., Sarkaria, J. N., & Chen, J. (2011) · Nature Cell Biology · doi:10.1038/ncb2240 · Cited by 305
Metadata
- Authors
- Reddy, P., Liu, L., Adhikari, D., Jagarlamudi, K., Rajareddy, S., Shen, Y., Du, C., Tang, W., Hämäläinen, T., Peng, S. L., Lan, Z.-J., Cooney, A. J., Huhtaniemi, I., & Liu, K.
- Venue
- Science
- Published
- 2008-02
- Volume
- 319
- Issue
- 5863
- Pages
- 611-613
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1995380492
- Cited by
- 856
- References
- 2
- FWCI
- 40.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Reddy, P., Liu, L., Adhikari, D., Jagarlamudi, K., Rajareddy, S., Shen, Y., Du, C., Tang, W., Hämäläinen, T., Peng, S. L., Lan, Z.-J., Cooney, A. J., Huhtaniemi, I., & Liu, K. (2008). Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool. Science. https://doi.org/10.1126/science.1152257
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