The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis
Abstract
BACKGROUND: Anti-Mullerian hormone (AMH) is a marker of ovarian reserve status and represents a good predictor of ovarian response to ovarian hyperstimulation. The aim of this study was to assess the accuracy of AMH and antral follicle count (AFC) as predictors of an excessive response in IVF/ICSI treatment. METHODS: A systematic review and meta-analysis of the existing literature was performed. Studies were included if 2 × 2 tables for the outcome excessive response in IVF patients in relation to AMH/AFC could be constructed. Using a bivariate meta-analytic model, both summary point estimates for sensitivity and specificity were calculated, as well as summary ROC curves. Clinical value was analysed by calculating post-test probabilities of excessive response at optimal cut-off levels, as well as the corresponding abnormal test rates. RESULTS: Nine studies reporting on AMH and five reporting on AFC were found. Summary estimates of sensitivity and specificity for AMH were 82 and 76%, respectively, and 82 and 80%, respectively, for AFC. Comparison of the summary estimates and ROC curves for AMH and AFC showed no statistical difference. Abnormal test rates for AMH and AFC amounted to ∼14 and 16%, respectively, at cut-off levels where test performance is optimal [likelihood ratio for a positive result (LR + ) > 8], with a post-test probability of ± 70%. CONCLUSIONS: Both AMH and AFC are accurate predictors of excessive response to ovarian hyperstimulation. Moreover, both tests appear to have clinical value. This opens ways to explore the potential of individualized FSH dose regimens based on ovarian reserve testing.
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Reitsma, J. B., Glas, A. S., Rutjes, A. W. S., Scholten, R. J. P. M., Bossuyt, P. M., & Zwinderman, A. H. (2005) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2005.02.022 · Cited by 3,369 · cited 1×
“A meta-analysis was performed using a bivariate regression model (Reitsma et al., 2005).”
MethodA systematic review of tests predicting ovarian reserve and IVF outcome
Broekmans, F. J., Kwee, J., Hendriks, D. J., Mol, B. W., & Lambalk, C. B. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml034 · Cited by 1,258
Self-citationSerum anti-Mullerian hormone levels: a novel measure of ovarian reserve
van Rooij, I. A. J. (2002) · Human Reproduction · doi:10.1093/humrep/17.12.3065 · Cited by 951
A unification of models for meta-analysis of diagnostic accuracy studies
Harbord, R. M., Deeks, J. J., Egger, M., Whiting, P., & Sterne, J. A. C. (2007) · Biostatistics · doi:10.1093/biostatistics/kxl004 · Cited by 751
Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review
Delvigne, A. (2002) · Human Reproduction Update · doi:10.1093/humupd/8.6.559 · Cited by 717
Baart, E. B., Martini, E., Eijkemans, M. J., Van Opstal, D., Beckers, N. G. M., Verhoeff, A., Macklon, N. S., & Fauser, B. C. J. M. (2007) · Human Reproduction · doi:10.1093/humrep/del484 · Cited by 609
Self-citationBroer, S. L., Mol, B. W. J., Hendriks, D., & Broekmans, F. J. M. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.12.013 · Cited by 546
Self-citationSerum anti-Mullerian hormone throughout the human menstrual cycle
La Marca, A., Stabile, G., Artenisio, A. C., & Volpe, A. (2006) · Human Reproduction · doi:10.1093/humrep/del291 · Cited by 532
Hehenkamp, W. J. K., Looman, C. W. N., Themmen, A. P. N., de Jong, F. H., te Velde, E. R., & Broekmans, F. J. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0331 · Cited by 509
Self-citationSeifer, D. B., MacLaughlin, D. T., Christian, B. P., Feng, B., & Shelden, R. M. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)03201-0 · Cited by 494
Cited by
The physiology and clinical utility of anti-Müllerian hormone in women
Dewailly, D., Andersen, C. Y., Balen, A., Broekmans, F., Dilaver, N., Fanchin, R., Griesinger, G., Kelsey, T. W., La Marca, A., Lambalk, C., et al. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt062 · Cited by 1,049
Self-citationLa Marca, A., & Sunkara, S. K. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt037 · Cited by 586
Dewailly, D., Lujan, M. E., Carmina, E., Cedars, M. I., Laven, J., Norman, R. J., & Escobar-Morreale, H. F. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt061 · Cited by 551
Monniaux, D., Clément, F., Dalbiès-Tran, R., Estienne, A., Fabre, S., Mansanet, C., & Monget, P. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.113.117077 · Cited by 233
The endocrinology of the menstrual cycle
Barbieri, R. L. (2014) · Methods in Molecular Biology · doi:10.1007/978-1-4939-0659-8_7 · Cited by 196
Metadata
- Authors
- Broer, S. L., Dolleman, M., Opmeer, B. C., Fauser, B. C., Mol, B. W., & Broekmans, F. J. M.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-07-28
- Volume
- 17
- Issue
- 1
- Pages
- 46-54
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2099586602
- Cited by
- 485
- References
- 46
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Broer, S. L., Dolleman, M., Opmeer, B. C., Fauser, B. C., Mol, B. W., & Broekmans, F. J. M. (2011). AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis. Human Reproduction Update. https://doi.org/10.1093/humupd/dmq034
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