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GENES AND DEVELOPMENTAL PATHWAYS
Abstract
The way in which genes control the growth and development of an organism is a central problem in biology, and one which is currently under study in diverse forms from phage to man. I would like to discuss an approach to this problem which makes use of a series of pseudoallelic genes in Drosophila. Such series of closely linked genes with related effects have, in several instances, been profitably exploited in the bacteria to learn more about how genes control biochemical pathways. Striking examples are the linked genes controlling histidine biosynthesis in Salmonella (Demerec and Hartman, 1959; Ames and Hartman, 1962), or lactose utilization in E. coli (Jacob and Monod, 1961a,b). It may be anticipated that pseudoallelic series affecting morphological traits, such as the case to be described below, can also be profitably exploited to learn more about how genes control developmental pathways.
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Cited by
PERSPECTIVE: EVOLUTIONARY DEVELOPMENTAL BIOLOGY AND THE PROBLEM OF VARIATION
Stern, D. L. (2000) · Evolution · doi:10.1111/j.0014-3820.2000.tb00544.x · Cited by 483
Segmental distribution of bithorax complex proteins during Drosophila development
Beachy, P. A., Helfand, S. L., & Hogness, D. S. (1985) · Nature · doi:10.1038/313545a0 · Cited by 413
Macdonald, P. M., Ingham, P., & Struhl, G. (1986) · Cell · doi:10.1016/0092-8674(86)90515-5 · Cited by 375
Chapter 9 Hox Genes and Vertebrate Axial Pattern
Wellik, D. M. (2009) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(09)88009-5 · Cited by 203
Genetic control of sensory connections in Drosophila
Vandervorst, P., & Ghysen, A. (1980) · Nature · doi:10.1038/286065a0 · Cited by 116
Metadata
- Authors
- LEWIS, E. B.
- Venue
- American Zoologist
- Publisher
- Oxford University Press (OUP)
- Published
- 1963-02
- Volume
- 3
- Issue
- 1
- Pages
- 33-56
- ISSN
- 0003-1569 (ISSN-L)
- OpenAlex
- W2066853527
- Cited by
- 366
- References
- 0
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- closed
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