Initial 2-year results of CardioCel® patch implantation in children
Abstract
OBJECTIVES: We present the initial 2-year results of CardioCel® patch (Admedus Regen Pty Ltd, Perth, WA, Australia) implantation in paediatric patients with congenital heart diseases. METHODS: This was a single-centre retrospective study with prospectively collected data of all patients aged 18 years and under operated for congenital heart disease. The patch was introduced in 2014, with clinical practice committee approval and a special consent in case of an Ozaki procedure. Standard follow-up was performed with systematic clinical exams and echocardiograms. In case of reoperation or graft failure, the patch was removed and sent for a histological examination. RESULTS: Between March 2014 and April 2016, 101 patients had surgical repair using a CardioCel patch. The mean age was 22 (±36.3) months, and the mean weight was 9.7 (±10.3) kg. No infections and no intraoperative implantation difficulties were associated with the patch. The median follow-up period was 212 (range 4-726) days. The overall 30-day postoperative mortality was 3.8% (n = 4), none of which were related to graft failure. Five children were reoperated because of graft failure, 4 of whom had the patch implanted for aortic and were aged less than 10 days. The indications for patch implantation in the aortic position were aortopulmonary window, truncus arteriosus, coarctation and aortic arch hypoplasia repair. The median time between the first and the second operation for graft failure was 245 (range 5-480) days. CONCLUSIONS: Our experience shows that the patch is well tolerated in the septal, valvar and pulmonary artery positions. However, we experienced graft failures in infants in the aortic position.
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ECM bioscaffolds provide an alternative to congenital infant defects such as those related to heart valves, given their prominent integration with the host's tissue and prevention of inflammation.
“On the other hand, ECM bioscaffolds provide an alternative to congenital infant defects such as those related to heart valves [209,210], given their prominent integration with the host's tissue and prevention of inflammation.”
From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [209]
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- Authors
- Pavy, C., Michielon, G., Robertus, J. L., Lacour-Gayet, F., & Ghez, O.
- Affiliations
- Royal Brompton Hospital (GB)
- Department of Cardiac Surgery, Royal Brompton Hospital, London, UK
- Corresponding author
- Ghez, Olivier
- Venue
- Interactive CardioVascular and Thoracic Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-10-24
- Volume
- 26
- Issue
- 3
- Pages
- 448-453
- ISSN
- 1569-9285 (ISSN-L)
- 1569-9293
- OpenAlex
- W2766416039
- Cited by
- 42
- References
- 12
- Citations by year
- 2025: 6 · 2024: 7 · 2023: 5 · 2022: 8 · 2021: 4 · 2020: 1 · 2019: 8 · 2018: 2 · 2017: 1
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Interactive Cardiovascular and Thoracic Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
- Keywords
- congenital heart disease, pediatric cardiac surgery, graft failure, aortopulmonary window, truncus arteriosus, coarctation of the aorta, aortic arch hypoplasia, reoperation, long-term outcomes
- MeSH terms
- Adolescent, Bioprosthesis, Blood Vessel Prosthesis, Child, Child, Preschool, Female, Heart Defects, Congenital, Humans, Infant, Infant, Newborn, Male, Reoperation, Retrospective Studies, Time Factors, Treatment Outcome, Blood Vessel Prosthesis Implantation
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