The DOI matches its Crossref record; 262 of the 262 references it cites were found in a registry or an index.
Effects of pre-and neonatal nicotine exposure in rodents: inconsistent evidence
Open accessAbstract
This review presents an analysis of the literature on behavioral effects of developmental exposure to nicotine, as assessed in rodent models that mimic the consequences for human offspring of maternal cigarette smoking. Despite the frequency of reports of low birth weight, hyperactivity, cognitive deficits, and psychiatric problems, inconsistencies exist in both the clinical and experimental literature. Confounding socioeconomic and other demographic variables may account for discrepancies in clinical reports, and the choice of developmental exposure period and the method of nicotine administration may explain differences in experimental outcomes. Analysis of a number of variables (e.g., physical, behavioral, and cognitive) shows that fetal exposure to nicotine does not consistently cause growth retardation or decreased birth weight, nor reliably affect motor activity. But combined pre- and neonatal exposure is likely to result in delayed reflex development, global impairments in learning and memory, and an increased incidence of symptoms that model psychiatric illness. There is also support for increased self-administration of nicotine and other drugs of abuse in animals exposed developmentally to nicotine, as well as potent effects on offspring responses to drug challenges. Unlike reports in the clinical literature, sexually dimorphic effects were not evident in most animal models. Possible neuroanatomical and cholinergic mechanisms responsible for behavioral changes are briefly discussed. Statistical and design considerations are provided to increase the translational value of this research and, most importantly, enhance the replicability of reported findings.
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“some studies found normal reflex development in exposed animals”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [180]
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Citations
Cites
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England, L. J., Aagaard, K., Bloch, M., Conway, K., Cosgrove, K., Grana, R., Gould, T. J., Hatsukami, D., Jensen, F., Kandel, D., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.013 · Cited by 181
Chirico, D., Romano, E., Famele, M., Draisci, R., Mancinelli, R., Pascucci, T., & Adriani, W. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.007 · Cited by 16
Developmental cannabinoid exposure: New perspectives on outcomes and mechanisms
Sobrian, S. K. (2016) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2016.10.010 · Cited by 5
Animal Models of Drug Addiction in Support of Novel Therapeutic Strategies
Frascella, J., Richardson, K. A., & McLemore, G. L. (2011) · ILAR Journal · doi:10.1093/ilar.52.3.233 · Cited by 3
Baguckaitė, D., Covey, J. A., & Reissland, N. (2026) · Acta Paediatrica · doi:10.1111/apa.70539 · Cited by 2
Metadata
- Authors
- Sobrian, S. K., & Holson, R. R.
- Affiliations
- Howard University (US)
- Corresponding author
- Sobrian, S. K.
- Venue
- ILAR Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-01-01
- Volume
- 52
- Issue
- 3
- Pages
- 251-294
- ISSN
- 1084-2020 (ISSN-L)
- OpenAlex
- W2145815038
- Cited by
- 8
- References
- 262
- Citations by year
- 2026: 3 · 2019: 1 · 2017: 1 · 2016: 2
- FWCI
- 0.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- ILAR Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- prenatal nicotine exposure, maternal smoking, low birth weight, hyperactivity, cognitive impairment, learning and memory, psychiatric symptoms, nicotine self-administration, cholinergic mechanisms, sexual dimorphism, rodent models, translational research, replicability
- MeSH terms
- Animals, Humans, Learning, Memory, Nicotine, Prenatal Exposure Delayed Effects
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