Cited by 8Prenatal Substance Exposure EffectsSmoking Behavior and CessationNicotinic Acetylcholine Receptors Study

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Effects of pre-and neonatal nicotine exposure in rodents: inconsistent evidence

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Sobrian, S. K., Holson, R. R.·2011·ILAR Journal

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Abstract

This review presents an analysis of the literature on behavioral effects of developmental exposure to nicotine, as assessed in rodent models that mimic the consequences for human offspring of maternal cigarette smoking. Despite the frequency of reports of low birth weight, hyperactivity, cognitive deficits, and psychiatric problems, inconsistencies exist in both the clinical and experimental literature. Confounding socioeconomic and other demographic variables may account for discrepancies in clinical reports, and the choice of developmental exposure period and the method of nicotine administration may explain differences in experimental outcomes. Analysis of a number of variables (e.g., physical, behavioral, and cognitive) shows that fetal exposure to nicotine does not consistently cause growth retardation or decreased birth weight, nor reliably affect motor activity. But combined pre- and neonatal exposure is likely to result in delayed reflex development, global impairments in learning and memory, and an increased incidence of symptoms that model psychiatric illness. There is also support for increased self-administration of nicotine and other drugs of abuse in animals exposed developmentally to nicotine, as well as potent effects on offspring responses to drug challenges. Unlike reports in the clinical literature, sexually dimorphic effects were not evident in most animal models. Possible neuroanatomical and cholinergic mechanisms responsible for behavioral changes are briefly discussed. Statistical and design considerations are provided to increase the translational value of this research and, most importantly, enhance the replicability of reported findings.

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Determinants of low birth weight: methodological assessment and meta-analysis.
Kramer, M. S. (1987) · Europe PMC (PubMed Central) · Cited by 2,682
Comparative aspects of the brain growth spurt
Dobbing, J., & Sands, J. (1979) · Early Human Development · doi:10.1016/0378-3782(79)90022-7 · Cited by 2,506
The epidemiology of smoking during pregnancy: smoking prevalence, maternal characteristics, and pregnancy outcomes
Cnattingius, S. (2004) · Nicotine & Tobacco Research · doi:10.1080/14622200410001669187 · Cited by 1,126
Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat.
Bayer, S. A., Altman, J., Russo, R. J., & Zhang, X. (1993) · PubMed · Cited by 912
A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.
Flores, C. M., Rogers, S. W., Pabreza, L. A., Wolfe, B. B., & Kellar, K. J. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08832-7 · Cited by 880
Guidelines on nicotine dose selection for in vivo research
Matta, S. G., Balfour, D. J., Benowitz, N. L., Boyd, R. T., Buccafusco, J. J., Caggiula, A. R., Craig, C. R., Collins, A. C., Damaj, M. I., Donny, E. C., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0441-0 · Cited by 824
Extrapolating brain development from experimental species to humans
Clancy, B., Finlay, B. L., Darlington, R. B., & Anand, K. J. S. (2007) · NeuroToxicology · doi:10.1016/j.neuro.2007.01.014 · Cited by 812
Comparing rat’s to human’s age: How old is my rat in people years?
Quinn, R. (2005) · Nutrition · doi:10.1016/j.nut.2005.04.002 · Cited by 682
Fetal Nicotine or Cocaine Exposure: Which One is Worse?
Slotkin, T. A. (1998) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37495-6 · Cited by 676
Trends in smoking before, during, and after pregnancy - Pregnancy Risk Assessment Monitoring System (PRAMS), United States, 31 sites, 2000-2005.
Tong, V. T., Dietz, P. M., Morrow, B., D’Angelo, D. V., Farr, S. L., Rockhill, K. M., & England, L. J. (2009) · PubMed · Cited by 617
Behavioral and Neural Consequences of Prenatal Exposure to Nicotine
ERNST, M., MOOLCHAN, E. T., & ROBINSON, M. L. (2001) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200106000-00007 · Cited by 590
OPEN‐FIELD BEHAVIOR IN THE RAT: WHAT DOES IT MEAN?*
Denenberg, V. H. (1969) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1969.tb12983.x · Cited by 582
Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children
Braun, J. M., Kahn, R. S., Froehlich, T., Auinger, P., & Lanphear, B. P. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9478 · Cited by 573
The dynamic effects of nicotine on the developing brain
Dwyer, J. B., McQuown, S. C., & Leslie, F. M. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.02.003 · Cited by 559
A preliminary report on cigarette smoking and the incidence of prematurity
Simpson, W. J. (1957) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(57)90391-5 · Cited by 527
Principles and pitfalls in the analysis of prenatal treatment effects in multiparous species
Holson, R. R., & Pearce, B. A. (1992) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(92)90020-b · Cited by 503
Case-Control Study of Attention-Deficit Hyperactivity Disorder and Maternal Smoking, Alcohol Use, and Drug Use During Pregnancy
Mick, E. O., Biederman, J., Faraone, S. V., Sayer, J., & Kleinman, S. (2002) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200204000-00009 · Cited by 490
Differential effects on cognitive functioning in 13- to 16-year-olds prenatally exposed to cigarettes and marihuana
Fried, P. A., Watkinson, B., & Gray, R. (2003) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(03)00029-1 · Cited by 458
Smoking in Pregnancy and Subsequent Child Development
Butler, N. R., & Goldstein, H. (1973) · BMJ · doi:10.1136/bmj.4.5892.573 · Cited by 449
Extent of nicotine and cotinine transfer to the human fetus, placenta and amniotic fluid of smoking mothers
Luck, W., Nau, H., Hansen, R., & Steldinger, R. (2017) · Developmental Pharmacology and Therapeutics · doi:10.1159/000457063 · Cited by 444
Births: final data for 2007.
Martin, J. A., Hamilton, B. E., Sutton, P. D., Ventura, S. J., Mathews, T. J., Kirmeyer, S., & Osterman, M. J. K. (2010) · PubMed · Cited by 419
Is maternal smoking during pregnancy a risk factor for attention deficit hyperactivity disorder in children?
Milberger, S., Biederman, J., Faraone, S. V., Chen, L., & Jones, J. T. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.9.1138 · Cited by 414
Maternal smoking during pregnancy and psychiatric adjustment in late adolescence
Fergusson, D. M., Woodward, L. J., & Horwood, L. J. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.8.721 · Cited by 396
Maternal Smoking during Pregnancy and Childhood Obesity
von Kries, R. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf128 · Cited by 385
Long-Term Consequences of Fetal and Neonatal Nicotine Exposure: A Critical Review
Bruin, J. E., Gerstein, H. C., & Holloway, A. C. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq103 · Cited by 379
Early determinants of overweight at 4.5 years in a population-based longitudinal study
Dubois, L., & Girard, M. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803141 · Cited by 373
The paradox of nicotinic acetylcholine receptor upregulation by nicotine
Wonnacott, S. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90242-z · Cited by 357
36??? and 48-Month Neurobehavioral Follow-up of Children Prenatally Exposed to Marijuana, Cigarettes, and Alcohol
Fried, P. A., & Watkinson, B. (1990) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-199004000-00003 · Cited by 356
Gender Differences in the Effects of Prenatal Stress on Brain Development and Behaviour
Weinstock, M. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9339-4 · Cited by 349
Maternal Smoking During Pregnancy and Psychopathology in Offspring Followed to Adulthood
Weissman, M. M., Warner, V., WICKRAMARATNE, P. J., & Kandel, D. B. (1999) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199907000-00020 · Cited by 346
Nicotine-induced upregulation of nicotinic receptors: Underlying mechanisms and relevance to nicotine addiction
Govind, A. P., Vezina, P., & Green, W. N. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.06.011 · Cited by 338
Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine
Fenster, C. P., Rains, M. F., Noerager, B., Quick, M. W., & Lester, R. A. J. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05747.1997 · Cited by 332
Maternal smoking during pregnancy and the risk of conduct disorder in boys
Wakschlag, L. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190098010 · Cited by 326
Elevated Risk of Tobacco Dependence Among Offspring of Mothers Who Smoked During Pregnancy: A 30-Year Prospective Study
Buka, S. L., Shenassa, E. D., & NIAURA, R. S. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.11.1978 · Cited by 326
Early life genetic, epigenetic and environmental factors shaping emotionality in rodents
Holmes, A., Guisquet, A. M. L., Vogel, E., Millstein, R. A., Leman, S., & Belzung, C. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.012 · Cited by 308
Prenatal adverse effects of nicotine on the developing brain.
Lichtensteiger, W., Ribary, U., Schlumpf, M., Odermatt, B., & Widmer, H. (1988) · Progress in Brain Research · doi:10.1016/s0079-6123(08)60502-6 · Cited by 282
Maternal Smoking During Pregnancy and Adult Male Criminal Outcomes
Brennan, P. A., Grekin, E. R., & Mednick, S. A. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.3.215 · Cited by 277
Smoking during pregnancy and offspring externalizing problems: An exploration of genetic and environmental confounds
D'Onofrio, B. M., Hulle, C. A. V., Waldman, I. D., Rodgers, J. L., Harden, K. P., Rathouz, P. J., & Lahey, B. B. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000072 · Cited by 267
Maternal smoking during pregnancy and smoking by adolescent daughters.
Kandel, D. B., Wu, P., & Davies, M. (1994) · American Journal of Public Health · doi:10.2105/ajph.84.9.1407 · Cited by 266
60??? and 72-Month Follow-up of Children Prenatally Exposed to Marijuana, Cigarettes, and Alcohol
Fried, P. A., Cm, O., & Watkinson, B. (1992) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-199212000-00001 · Cited by 251
Associations of Maternal Prenatal Smoking with Child Adiposity and Blood Pressure
Oken, E., Huh, S. Y., Taveras, E. M., Rich-Edwards, J. W., & Gillman, M. W. (2005) · Obesity Research · doi:10.1038/oby.2005.248 · Cited by 247
Nicotine administration to rats: Methodological considerations
Murrin, L. C., Ferrer, J. R., Zeng, W., & Haley, N. J. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90020-8 · Cited by 237
Mental development of children whose mothers smoked during pregnancy.
Naeye, R. L., & Peters, E. C. (1984) · PubMed · Cited by 227
Association of prenatal maternal or postnatal child environmental tobacco smoke exposure and neurodevelopmental and behavioral problems in children.
Eskenazi, B., & Castorina, R. (1999) · Environmental Health Perspectives · doi:10.1289/ehp.99107991 · Cited by 220
Effect of antenatal exposure to maternal smoking on behavioural problems and academic achievement in childhood: prospective evidence from a dutch birth cohort
Batstra, L., Hadders-Algra, M., & Neeleman, J. (2003) · Early Human Development · doi:10.1016/j.earlhumdev.2003.09.001 · Cited by 213
Further evidence of an association between maternal smoking during pregnancy and attention deficit hyperactivity disorder: findings from a high-risk sample of siblings
Milberger, S., Biederman, J., Faraone, S. V., & Jones, J. (1998) · Journal of Clinical Child Psychology · doi:10.1207/s15374424jccp2703_11 · Cited by 211
If nicotine is a developmental neurotoxicant in animal studies, dare we recommend nicotine replacement therapy in pregnant women and adolescents?
Slotkin, T. A. (2008) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2007.09.002 · Cited by 206
Maternal separation alters drug intake patterns in adulthood in rats
Moffett, M. C., Vicentic, A., Kozel, M. A., Plotsky, P. M., Francis, D. D., & Kuhar, M. J. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.08.003 · Cited by 205
Maternal cigarette smoking and child psychiatric morbidity: a longitudinal study
Williams, G. M., O'Callaghan, M., Najman, J. M., Bor, W., Andersen, F. M. J., Richards, A. D., & BSc, C. U. (1998) · PEDIATRICS · doi:10.1542/peds.102.1.e11 · Cited by 203
Maternal Smoking and Fetal Growth Characteristics in Different Periods of Pregnancy: The Generation R Study
Jaddoe, V. W. V., Verburg, B. O., de Ridder, M. A. J., Hofman, A., Mackenbach, J. P., Moll, H. A., Steegers, E. A. P., & Witteman, J. C. M. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm014 · Cited by 202
Contributions of parental alcoholism, prenatal substance exposure, and genetic transmission to child ADHD risk: a female twin study
Knopik, V. S., Sparrow, E. P., Madden, P. A. F., Bucholz, K. K., Hudziak, J. J., Reich, W., Slutske, W. S., Grant, J. D., McLaughlin, T., Todorov, A. A., et al. (2005) · Psychological Medicine · doi:10.1017/s0033291704004155 · Cited by 200
Effects of prenatal nicotine exposure on development of central and peripheral cholinergic neurotransmitter systems. Evidence for cholinergic trophic influences in developing brain.
Navarro, H. A., Seidler, F. J., Eylers, J. P., Baker, F. E., Dobbins, S. S., Lappi, S. E., & Ta, S. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21095-3 · Cited by 198
Maternal cigarette smoking during pregnancy, low birth weight and subsequent blood pressure in early childhood
Blake, K. V., Gurrin, L. C., Evans, S. F., Beilin, L. J., Landau, L. I., Stanley, F. J., & Newnham, J. P. (2000) · Early Human Development · doi:10.1016/s0378-3782(99)00064-x · Cited by 197
Pre- and post-natal growth in children of women who smoked in pregnancy
Vik, T., Jacobsen, G. W., VATTEN, L. J., & Bakketeig, L. S. (1996) · Early Human Development · doi:10.1016/0378-3782(96)01735-5 · Cited by 191
Intellectual Impairment in Children of Women Who Smoke Cigarettes During Pregnancy
Olds, D. L., Henderson, C., & Tatelbaum, R. C. (1994) · PEDIATRICS · doi:10.1542/peds.93.6.973 · Cited by 191
Downregulation of nicotinic receptor function after chronic nicotine infusion.
Marks, M. J., Grady, S. R., & Collins, A. C. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39368-7 · Cited by 190
Childhood obesity is associated with maternal smoking in pregnancy
Toschke, A. M., Koletzko, B. V., Slikker, W., Hermann, M., & von Kries, R. (2002) · European Journal of Pediatrics · doi:10.1007/s00431-002-0983-z · Cited by 187
Fetal and adolescent nicotine administration: effects on CNS serotonergic systems
Xu, Z., Seidler, F. J., Ali, S. F., Slikker, W., & Slotkin, T. A. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02797-4 · Cited by 186
Smoking during pregnancy: how reliable are maternal self reports in New Zealand?
Ford, R. P., Tappin, D. M., Schlüter, P. J., & Wild, C. J. (1997) · Journal of Epidemiology & Community Health · doi:10.1136/jech.51.3.246 · Cited by 186
A FOLLOW‐UP STUDY UP TO THE AGE OF 14 OF CHILDREN WHOSE MOTHERS SMOKED DURING PREGNANCY
Rantakallio, P. T. (1983) · Acta Paediatrica · doi:10.1111/j.1651-2227.1983.tb09805.x · Cited by 183
Prenatal Nicotine Exposure Evokes Alterations of Cell Structure in Hippocampus and Somatosensory Cortex
Roy, T. S., Seidler, F. J., & Slotkin, T. A. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.1.124 · Cited by 183
An assessment of the long-term developmental and behavioral teratogenicity of prenatal nicotine exposure
Vaglenova, J., Birru, S., Pandiella, N. M., & Breese, C. R. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.07.005 · Cited by 180
Effects of prenatal cigarette and marijuana exposure on drug use among offspring
Porath, A. J., & Fried, P. A. (2005) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2004.12.003 · Cited by 178
Maternal Smoking during Pregnancy and Children's Cognitive and Physical Development: A Causal Risk Factor?
Gilman, S. E., Gardener, H. E., & Buka, S. L. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn175 · Cited by 172
Prenatal exposure to nicotine impairs nervous system development at a dose which does not affect viability or growth
Navarro, H. A., Seidler, F. J., Schwartz, R. D., Baker, F. E., Dobbins, S. S., & Slotkin, T. A. (1989) · Brain Research Bulletin · doi:10.1016/0361-9230(89)90146-9 · Cited by 171
Reading and language in 9- to 12-year olds prenatally exposed to cigarettes and marijuana
Fried, P. A., Watkinson, B., & Siegel, L. S. (1997) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(97)00015-9 · Cited by 170
Effects of prenatal nicotine exposure on biochemical development of rat brain regions: maternal drug infusions via osmotic minipumps.
Slotkin, T. A., Orband‐Miller, L. A., Queen, K. L., Whitmore, W. L., & Seidler, F. J. (1987) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22572-1 · Cited by 167
Early Intrauterine Exposure to Tobacco-inhaled Products and Obesity
Toschke, A. M. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwg258 · Cited by 163
Tobacco Use and Secondhand Smoke Exposure During Pregnancy: An Investigative Survey of Women in 9 Developing Nations
Bloch, M., Althabe, F., Onyamboko, M. A., Kaseba-Sata, C., Castilla, E. E., Freire, S., Garces, A. L., Parida, S., Goudar, S. S., Kadir, M. M., et al. (2008) · American Journal of Public Health · doi:10.2105/ajph.2007.117887 · Cited by 161
Maternal Smoking and Hyperactivity in 8-Year-Old Children
Kotimaa, A., Moilanen, I. K., Taanila, A. M., Ebeling, H. E., Smalley, S. L., McGough, J. J., Hartikainen, A., & Järvelin, M. (2003) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000046866.56865.a2 · Cited by 161
Prenatal Nicotine Exposure Alters Early Pancreatic Islet and Adipose Tissue Development with Consequences on the Control of Body Weight and Glucose Metabolism Later in Life
Somm, E., Schwitzgebel, V. M., Vauthay, D. M., Camm, E. J., Chen, C. Y., Giacobino, J.-P., Sizonenko, S. V., Aubert, M. L., & Hüppi, P. S. (2008) · Endocrinology · doi:10.1210/en.2008-0361 · Cited by 159
Permanent, Sex-Selective Effects of Prenatal or Adolescent Nicotine Exposure, Separately or Sequentially, in Rat Brain Regions: Indices of Cholinergic and Serotonergic Synaptic Function, Cell Signaling, and Neural Cell Number and Size at 6 Months of Age
Slotkin, T. A., MacKillop, E. A., Rudder, C. L., Ryde, I. T., Tate, C. A., & Seidler, F. J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301231 · Cited by 149
A comparison of active and passive smoking during pregnancy: Long-term effects
Makin, J., Fried, P. A., & Watkinson, B. (1991) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(91)90021-n · Cited by 149
Effects of maternal smoking in pregnancy on prenatal brain development. The Generation R Study
Roza, S. J., Verburg, B. O., Jaddoe, V. W. V., Albert Hofman, D., Mackenbach, J. P., Steegers, E. A. P., Witteman, J. C. M., Verhulst, F. C., & Tiemeier, H. W. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05393.x · Cited by 148
Nicotine Evokes Cell Death in Embryonic Rat Brain during Neurulation
Roy, T. S., Andrews, J. E., Seidler, F. J., & Slotkin, T. A. (1998) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37911-x · Cited by 147
Fetal and neonatal exposure to nicotine in Wistar rats results in increased beta cell apoptosis at birth and postnatal endocrine and metabolic changes associated with type 2 diabetes
Holloway, A., Lim, G. E., Petrik, J., Foster, W. G., Morrison, K. M., & Gerstein, H. (2005) · Diabetologia · doi:10.1007/s00125-005-0022-5 · Cited by 142
Prenatal Smoking Exposure and the Risk of Psychiatric Morbidity Into Young Adulthood
Ekblad, M. O., Gissler, M., Lehtonen, L., & Korkeila, J. J. A. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.92 · Cited by 141
Maternal smoking during pregnancy in relation to child overweight: follow-up to age 8 years
Chen, A., Pennell, M. L., Klebanoff, M. A., Rogan, W. J., & Longnecker, M. P. (2005) · International Journal of Epidemiology · doi:10.1093/ije/dyi218 · Cited by 141
Association of Environmental Toxicants and Conduct Disorder in U.S. Children: NHANES 2001–2004
Braun, J. M., Froehlich, T. E., Daniels, J. L., Dietrich, K. N., Hornung, R., Auinger, P., & Lanphear, B. P. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11177 · Cited by 141
Smoking in pregnancy and development into early adulthood.
Fogelman, K., & Manor, O. (1988) · BMJ · doi:10.1136/bmj.297.6658.1233 · Cited by 140
Maternal smoking and drinking during pregnancy and the risk for child and adolescent psychiatric disorders.
Hill, S. Y., Lowers, L., Locke, J., & Shen, S. (2000) · Journal of Studies on Alcohol · doi:10.15288/jsa.2000.61.661 · Cited by 139
Cigarette consumption and serum cotinine in relation to birthweight
Haddow, J. E., Knight, G. J., Palomaki, G. E., Kloza, E. M., & Wald, N. (1987) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1987.tb03174.x · Cited by 138
Prenatal nicotine effects on memory in rats: pharmacological and behavioral challenges
Levin, E. D., Wilkerson, A., Jones, J. P., Channelle Christopher, N., & Briggs, S. J. (1996) · Developmental Brain Research · doi:10.1016/s0165-3806(96)00144-7 · Cited by 137
Smoking during Pregnancy and Offspring Fat and Lean Mass in Childhood
Leary, S. D., Smith, G. D., Rogers, I., Reilly, J. J., Wells, J. C. K., & Ness, A. (2006) · Obesity · doi:10.1038/oby.2006.268 · Cited by 137
Prenatal exposure to nicotine via maternal infusions: effects on development of catecholamine systems.
Navarro, H. A., Seidler, F. J., Whitmore, W. W., & Ta, S. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24623-7 · Cited by 137
The prenatal stress syndrome: Current status
Ward, I. L. (1984) · Psychoneuroendocrinology · doi:10.1016/0306-4530(84)90016-7 · Cited by 136
Visuoperceptual functioning differs in 9- to 12-year olds prenatally exposed to cigarettes and marihuana
Fried, P. A., & Watkinson, B. (2000) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(99)00046-x · Cited by 131
Prenatal nicotine exposure and cognitive performance in rats
Levin, E. D., Briggs, S. J., Christopher, N. C., & Rose, J. E. (1993) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(93)90006-a · Cited by 130
Prenatal nicotine exposure modifies behavior of mice through early development.
Ajarem, J., & Ahmad, M. (1998) · Pharmacology, Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00408-5 · Cited by 128
Maternal smoking during pregnancy and school performance at age 15
Lambe, M., Hultman, C., Torr??ng, A., MacCabe, J., & Cnattingius, S. (2006) · Epidemiology · doi:10.1097/01.ede.0000231561.49208.be · Cited by 124
Growth from Birth to Early Adolescence in Offspring Prenatally Exposed to Cigarettes and Marijuana
Fried, P. A., Watkinson, B., & Gray, R. (1999) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(99)00009-4 · Cited by 121
Effects of low birth weight, maternal smoking in pregnancy and social class on the phenotypic manifestation of Attention Deficit Hyperactivity Disorder and associated antisocial behaviour: investigation in a clinical sample
Langley, K., Holmans, P., van den Bree, M. B. M., & Thapar, A. (2007) · BMC Psychiatry · doi:10.1186/1471-244x-7-26 · Cited by 121
Cholinergic receptors in heart and brainstem of rats exposed to nicotine during development: implications for hypoxia tolerance and perinatal mortality
Slotkin, T. A., Epps, T. A., Stenger, M. L., Sawyer, K. J., & Seidler, F. J. (1999) · Developmental Brain Research · doi:10.1016/s0165-3806(98)00173-4 · Cited by 120
Maternal smoking during pregnancy and child behaviour problems: The Generation R Study
Roza, S. J., Verhulst, F. C., Jaddoe, V. W., Steegers, E. A., Mackenbach, J. P., Hofman, A., & Tiemeier, H. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyn163 · Cited by 118
Central auditory processing in school-age children prenatally exposed to cigarette smoke
Mccartney, J. S., Fried, P. A., & Watkinson, B. (1994) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(94)90048-5 · Cited by 117
Chronic Nicotine Selectively Enhances α4β2* Nicotinic Acetylcholine Receptors in the Nigrostriatal Dopamine Pathway
Xiao, C., Nashmi, R., McKinney, S. L., Cai, H., McIntosh, J. M., & Lester, H. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2939-09.2009 · Cited by 117
Maternal smoking during pregnancy and infant head circumference at birth
Källén, K. (2000) · Early Human Development · doi:10.1016/s0378-3782(00)00077-3 · Cited by 115
In utero nicotine exposure causes persistent, gender‐dependant changes in locomotor activity and sensitivity to nicotine in C57Bl/6 mice
Pauly, J. R., Sparks, J. A., Hauser, K. F., & Pauly, T. H. (2004) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.05.009 · Cited by 113
Hyperkinesis and Maternal Smoking
Denson, R., Nanson, J., & Mcwatters, M. A. (1975) · Canadian Psychiatric Association Journal · doi:10.1177/070674377502000302 · Cited by 111
Growth and pubertal milestones during adolescence in offspring prenatally exposed to cigarettes and marihuana
Fried, P. A., James, D., & Watkinson, B. (2001) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(01)00161-1 · Cited by 110
Neurobehavioral and immunological effects of prenatal cocaine exposure in rat
Sobrian, S. K., Burton, L. E., Robinson, N. L., Ashe, W. K., James, H., Stokes, D. L., & Turner, L. M. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90299-w · Cited by 109
Statistical issues and techniques appropriate for developmental neurotoxicity testing
Holson, R. R., Freshwater, L., Maurissen, J. P. J., MOSER, V. C., & Phang, W. (2007) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2007.06.001 · Cited by 108
Prenatal Nicotine Exposure Alters the Response to Nicotine Administration in Adolescence: Effects on Cholinergic Systems During Exposure and Withdrawal
Abreu‐Villaça, Y., Seidler, F. J., Tate, C. A., Cousins, M. M., & Slotkin, T. A. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300401 · Cited by 107
Upregulation of nicotinic receptors following continuous infusion of nicotine is brain-region-specific
Sanderson, E. M., Drasdo, A. L., McCrea, K. E., & Wonnacott, S. (1993) · Brain Research · doi:10.1016/0006-8993(93)91104-z · Cited by 106
Hyperactivity in the offspring of nicotine-treated rats: Role of the mesolimbic and nigrostriatal dopaminergic pathways
Richardson, S. A., & Tizabi, Y. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90018-3 · Cited by 106
Behavioral Teratogenicity Induced by Nonforced Maternal Nicotine Consumption
Paz, R., Barsness, B., Martenson, T., Tanner, D., & Allan, A. M. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301066 · Cited by 105
Effect of Maternal Smoking During Pregnancy on Offspring's Cognitive Ability: Empirical Evidence for Complete Confounding in the US National Longitudinal Survey of Youth
Batty, G., Der, G., & Deary, I. (2006) · Pediatrics · doi:10.1542/peds.2006-0168 · Cited by 104
Direct and Passive Prenatal Nicotine Exposure and the Development of Externalizing Psychopathology
Gatzke‐Kopp, L. M., & Beauchaine, T. P. (2007) · Child Psychiatry & Human Development · doi:10.1007/s10578-007-0059-4 · Cited by 103
Undernutrition and the developing brain: the use of animal models to elucidate the human problem
Dobbing, J. (1971) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4684-7236-3_29 · Cited by 102
Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin c: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys
Slotkin, T. A., Seidler, F. J., Qiao, D., Aldridge, J. E., Tate, C. A., Cousins, M. M., Proskocil, B. J., Sekhon, H. S., Clark, J. A., Lupo, S. L., et al. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300544 · Cited by 101
Nicotine Exposure During a Critical Period of Development Leads to Persistent Changes in Nicotinic Acetylcholine Receptors of Adult Rat Brain
Miao, H., Liu, C., Bishop, K., Gong, Z., Nordberg, A. K., & Zhang, X. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70020752.x · Cited by 101
Prenatal smoking exposure and psychiatric symptoms in adolescence
Indredavik, M. S., Brubakk, A., Romundstad, P., & Vik, T. (2007) · Acta Paediatrica · doi:10.1111/j.1651-2227.2006.00148.x · Cited by 101
Maternal Smoking during Pregnancy and Delinquency of the Offspring: An Association without Causation?
Rantakallio, P. T., Läärä, E., Isohanni, M. K., & Moilanen, I. K. (1992) · International Journal of Epidemiology · doi:10.1093/ije/21.6.1106 · Cited by 101
Maternal smoking during pregnancy and offspring IQ
Breslau, N. (2005) · International Journal of Epidemiology · doi:10.1093/ije/dyi163 · Cited by 101
ADHD after fetal exposure to maternal smoking
Lindblad, F., & Hjern, A. (2010) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntq017 · Cited by 101
Inhibition of DNA synthesis in neonatal rat brain regions caused by acute nicotine administration
McFarland, B. J., Seidler, F. J., & Slotkin, T. A. (1991) · Developmental Brain Research · doi:10.1016/0165-3806(91)90008-7 · Cited by 100
Alterations in hippocampal cholinergic receptors and hippocampal behaviors after early exposure to nicotine
Yanai, J., Pick, C. G., Rogel-Fuchs, Y., & Zahalka, E. A. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90069-a · Cited by 99
Effects of maternal nicotine injections on brain development in the rat: Ornithine decarboxylase activity, nucleic acids and proteins in discrete brain regions
Slotkin, T. A., Greer, N. L., Faust, J. B., Cho, H., & Seidler, F. J. (1986) · Brain Research Bulletin · doi:10.1016/0361-9230(86)90159-0 · Cited by 99
Is Prenatal Smoking Associated With a Developmental Pattern of Conduct Problems in Young Boys?
Wakschlag, L. S., Pickett, K. E., Kasza, K., & Loeber, R. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000198597.53572.3e · Cited by 97
The effects of prenatal nicotine on radial-arm maze performance in rats
Sorenson, C. A., Raskin, L. A., & Suh, Y. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90117-k · Cited by 97
A dose-response relationship between maternal smoking during late pregnancy and adult intelligence in male offspring
Mortensen, E. L., Michaelsen, K. F., Sanders, S. A., & Reinisch, J. M. (2005) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2004.00622.x · Cited by 96
Prenatal nicotine affects fetal testosterone and sexual dimorphism of saccharin preference
LICHTENSTEIGER, W., & Schlumpf, M. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90018-8 · Cited by 96
Two distinct kinetic phases of desensitization of acetylcholine receptors of clonal rat PC12 cells.
Boyd, N. D. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016646 · Cited by 95
Effects of Gestational Nicotine Exposure on Hippocampal Morphology
Roy, T. S., & Sabherwal, U. (1998) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(97)00137-2 · Cited by 95
Prenatal cocaine and/or nicotine exposure in rats: Preliminary findings on long-term cognitive outcome and genital development at birth
Cutler, A. (1996) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(96)00125-0 · Cited by 95
Maternal smoking during pregnancy and risk to boys’ conduct disturbance: an examination of the causal hypothesis
Silberg, J. L., Parr, T. L. S., Neale, M. C., Rutter, M. L., Angold, A. C., & Eaves, L. J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01477-4 · Cited by 95
Activation and Desensitization of Nicotinic α7-type Acetylcholine Receptors by Benzylidene Anabaseines and Nicotine
Papke, R. L., Kem, W. R., Soti, F. S., López‐Hernández, G. Y., & Horenstein, N. A. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.150151 · Cited by 94
Prenatal nicotine-exposure alters fetal autonomic activity and medullary neurotransmitter receptors: Implications for sudden infant death syndrome
Duncan, J. R., Garland, M., Myers, M. M., Fifer, W. P., Yang, M., Kinney, H. C., & Stark, R. I. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91629.2008 · Cited by 93
Prenatal cocaine and/or nicotine exposure produces depression and anxiety in aging rats
Sobrian, S. K., Marr, L., & Ressman, K. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00042-3 · Cited by 92
Fetal nicotine exposure ablates the ability of postnatal nicotine challenge to release norepinephrine from rat brain regions
Seidler, F. J., Levin, E. D., Lappi, S. E., & Slotkin, T. A. (1992) · Developmental Brain Research · doi:10.1016/0165-3806(92)90170-2 · Cited by 92
Pregnancy Smoking and Childhood Conduct Problems: A Causal Association?
Maughan, B., Taylor, C., Taylor, A., Butler, N. R., & Bynner, J. M. (2001) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00800 · Cited by 92
The effects of prenatal stress, and of prenatal alcohol and nicotine exposure, on human sexual orientation
Ellis, L., & Cole-Harding, S. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00564-9 · Cited by 91
Deficits in development of central cholinergic pathways caused by fetal nicotine exposure: Differential effects on choline acetyltransferase activity and [3H]hemicholinium-3 binding
Zahalka, E. A., Seidler, F. J., Lappi, S. E., McCook, E. C., Yanai, J., & Slotkin, T. A. (1992) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(92)90047-e · Cited by 90
Comparison of Self‐Reported Smoking and Urinary Cotinine Levels in a Rural Pregnant Population
Britton, G. R., Brinthaupt, J., Stehle, J. M., & James, G. D. (2004) · Journal of Obstetric, Gynecologic & Neonatal Nursing · doi:10.1177/0884217504264866 · Cited by 89
Neonatal nicotine exposure impairs nicotinic enhancement of central auditory processing and auditory learning in adult rats
Liang, K., Poytress, B. S., Chen, Y., Leslie, F. M., Weinberger, N. M., & Metherate, R. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04945.x · Cited by 89
Prenatal Nicotine Exposure Alters the Responses to Subsequent Nicotine Administration and Withdrawal in Adolescence: Serotonin Receptors and Cell Signaling
Slotkin, T. A., Tate, C. A., Cousins, M. M., & Seidler, F. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300988 · Cited by 88
Neonatal nicotine exposure induces permanent changes in brain nicotinic receptors and behaviour in adult mice
Nordberg, A. K., Zhang, X. L., Fredriksson, A., & Eriksson, P. (1991) · Developmental Brain Research · doi:10.1016/0165-3806(91)90079-x · Cited by 88
Associations of Maternal Prenatal Smoking with Early Childhood Physical Aggression, Hyperactivity-Impulsivity, and Their Co-Occurrence
Huijbregts, S. C. J., Séguin, J. R., Zoccolillo, M., Boivin, M., & Tremblay, R. E. (2007) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-006-9073-4 · Cited by 88
Prenatal effects of maternal smoking on daughters' smoking: nicotine or testosterone exposure?
Kandel, D. B., & Udry, J. R. (1999) · American Journal of Public Health · doi:10.2105/ajph.89.9.1377 · Cited by 87
Hyperactivity Induced by Prenatal Nicotine Exposure Is Associated with an Increase in Cortical Nicotinic Receptors
Tizabi, Y., Popke, E. J., Rahman, M. A., Nespor, S. M., & Grunberg, N. E. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00461-3 · Cited by 87
Intrauterine Exposure to Alcohol and Tobacco Use and Childhood IQ: Findings from a Parental-Offspring Comparison within the Avon Longitudinal Study of Parents and Children
Alati, R., Macleod, J., Hickman, M., Sayal, K. S., May, M., Smith, G. D., & Lawlor, D. A. (2008) · Pediatric Research · doi:10.1203/pdr.0b013e318187cc31 · Cited by 85
Prenatal stress as possible aetiogenetic factor of homosexuality in human males.
Dörner, G., Geier, T., Ahrens, L., Krell, L., Münx, G., Sieler, H., Kittner, E., & Müller, H. (1980) · PubMed · Cited by 84
Maternal Alcohol Ingestion and Cigarette Smoking and Their Effects on Newborn Conditioning
Martin, J. C., Martin, D. C., Lund, C., & Streissguth, A. P. (1977) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1977.tb05879.x · Cited by 84
Maternal smoking, social class and outcomes of pregnancy
Villalbí, J. R., Salvador, J., Serral, G., Rodríguez‐Sanz, M., & Borrell, C. (2007) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2007.00845.x · Cited by 83
Prevention of intellectual impairment in children of women who smoke cigarettes during pregnancy.
Olds, D. L., Henderson, C., & Tatelbaum, R. C. (1994) · PubMed · Cited by 81
Smoking during pregnancy and its effects on child cognitive ability from the ages of 8 to 12 years
Fergusson, D. M., & Lloyd, M. (1991) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.1991.tb00700.x · Cited by 81
Effects of prenatal nicotine exposure on the morphogenesis of somatosensory cortex
Roy, T. S., & Sabherwal, U. (1994) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(94)90030-2 · Cited by 81
Parental smoking and childhood obesity--is maternal smoking in pregnancy the critical exposure?
von Kries, R., Bolte, G., Baghi, L., Toschke, A. M., & for the GME Study Group (2007) · International Journal of Epidemiology · doi:10.1093/ije/dym239 · Cited by 81
Increased nicotine self-administration following prenatal exposure in female rats
LEVIN, E., LAWRENCE, S., PETRO, A., HORTON, K., SEIDLER, F., & SLOTKIN, T. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.11.006 · Cited by 80
Is prenatal tobacco exposure a risk factor for early adolescent smoking? A follow-up study
Cornelius, M. D., Leech, S. L., Goldschmidt, L., & Day, N. L. (2005) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2005.05.006 · Cited by 79
Fetal alcohol spectrum disorders: Extending the range of structural defects
Jones, K. L., Hoyme, H. E., Robinson, L. K., Campo, M. D., Manning, M. A., Prewitt, L. M., & Chambers, C. (2010) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33675 · Cited by 78
Acetylcholine receptor desensitization induced by nicotine in rat medial habenula neurons
Lester, R. A. J., & Dani, J. A. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.74.1.195 · Cited by 77
Effects of Transdermal Nicotine or Smoking on Nicotine Concentrations and Maternal-Fetal Hemodynamics
ONCKEN, C. (1997) · Obstetrics & Gynecology · doi:10.1016/s0029-7844(97)00309-8 · Cited by 77
Desensitization of central cholinergic mechanisms and neuroadaptation to nicotine
Ochoa, E. L. M., Li, L., & McNamee, M. G. (1990) · Molecular Neurobiology · doi:10.1007/bf02780343 · Cited by 77
Prenatal smoke exposure alters growth in limb proportions and head shape in the midgestation human fetus
Lampl, M., Kuzawa, C. W., & Jeanty, P. (2003) · American Journal of Human Biology · doi:10.1002/ajhb.10140 · Cited by 77
Prenatal nicotine exposure impairs β-adrenergic function: Persistent chronotropic subsensitivity despite recovery from deficits in receptor binding
Navarro, H. A., Mills, E., Seidler, F. J., Baker, F. E., Lappi, S. E., Tayyeb, M. I., Spencer, J. R., & Slotkin, T. A. (1990) · Brain Research Bulletin · doi:10.1016/0361-9230(90)90066-9 · Cited by 76
Gestational nicotine exposure reduces nicotinic cholinergic receptor (nAChR) expression in dopaminergic brain regions of adolescent rats
Chen, H., Parker, S. L., Matta, S. G., & Sharp, B. M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04229.x · Cited by 75
Cryptic brain cell injury caused by fetal nicotine exposure is associated with persistent elevations of c-fos protooncogene expression1Supported by a grant from the Smokeles Tobacco Research Council.1
Slotkin, T. A., McCook, E. C., & Seidler, F. J. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01345-5 · Cited by 74
Impact of fetal nicotine exposure on development of rat brain regions: critical sensitive periods or effects of withdrawal?
Slotkin, T. A., Lappi, S. E., & Seidler, F. J. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90224-y · Cited by 72
Maternal Transmission of Nicotine Dependence: Psychiatric, Neurocognitive and Prenatal Factors
NIAURA, R. S., Bock, B. C., Lloyd, E. E., Brown, R. A., Lipsitt, L. P., & Buka, S. L. (2001) · American Journal on Addictions · doi:10.1080/105504901750160420 · Cited by 72
The effects of maternal nicotine absorption or hypoxic episodes upon appetitive behavior of rat offspring
Martin, J. C., & Becker, R. (1971) · Developmental Psychobiology · doi:10.1002/dev.420040205 · Cited by 72
Long-lasting teratogenic effects of nicotine on cognition: Gender specificity and role of AMPA receptor function
Vaglenova, J., Parameshwaran, K., Suppiramaniam, V. D., Breese, C. R., Pandiella, N., & Birru, S. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.06.009 · Cited by 72
Nicotine exposure during the neonatal brain growth spurt produces hyperactivity in preweanling rats
Thomas, J. D., Garrison, M. E., Slawecki, C. J., Ehlers, C. L., & Riley, E. P. (2000) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(00)00096-9 · Cited by 72
Prenatal nicotine exposure changes natural and drug‐induced reinforcement in adolescent male rats
Franke, R. M., Park, M., Belluzzi, J. D., & Leslie, F. M. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06253.x · Cited by 71
Does Prenatal Nicotine Exposure Sensitize the Brain to Nicotine-Induced Neurotoxicity in Adolescence?
Abreu-Villaça, Y., Seidler, F. J., & Slotkin, T. A. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300443 · Cited by 70
Maternal nicotine exposure increases nicotine preference in periadolescent male but not female C57Bl/6J mice
Klein, L. C., & Klein, L. C. (2003) · Nicotine & Tobacco Research · doi:10.1080/14622200307257 · Cited by 70
Late emerging effects of prenatal and early postnatal nicotine exposure on the cholinergic system and anxiety-like behavior
Eppolito, A. K., Bachus, S. E., McDonald, C. G., Meador-Woodruff, J. H., & Smith, R. F. (2010) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2009.12.009 · Cited by 69
Growth, development and activity in rat offspring following maternal drug exposure
Martin, J. C., Martin, D. C., Radow, B. L., & Sigman, G. (1976) · Experimental Aging Research · doi:10.1080/03610737608257179 · Cited by 65
Perinatal Effects of Nicotine
Nasrat, H. A., Al‐Hachim, G. M., & Mahmood, F. A. (2009) · Biology of the Neonate · doi:10.1159/000242503 · Cited by 63
Smoking in pregnancy and children’s mental and motor development at age 1 and 5 years
Trasti, N., Vik, T., Jacobsen, G. W., & Bakketeig, L. S. (1999) · Early Human Development · doi:10.1016/s0378-3782(99)00017-1 · Cited by 63
Maternal cigarette smoking during pregnancy and the child's subsequent development: I. Physical growth to the age of 6 1/2 years.
Hg, D., Ak, M., Ingram, S., & Cm, H. (1976) · PubMed · Cited by 63
Fetal growth retardation in rats exposed to cigarette smoke during pregnancy
Younoszai, M. K., Peloso, J., & Haworth, J. C. (1969) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(16)34295-8 · Cited by 63
Prenatal nicotine exposure and the programming of metabolic and cardiovascular disorders
Somm, E., Schwitzgebel, V., Vauthay, D. M., Aubert, M. L., & Hüppi, P. S. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.02.026 · Cited by 61
Prenatal Nicotine Sex-Dependently Alters Agonist-Induced Locomotion and Stereotypy
Shacka, J. J., Fennell, O. B., & Robinson, S. E. (1997) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(97)00063-9 · Cited by 60
In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats
Abou-Donia, M. B., Khan, W. A., Dechkovskaia, A. M., Goldstein, L. B., Bullman, S. L., & Abdel-Rahman, A. A. (2006) · Archives of Toxicology · doi:10.1007/s00204-006-0077-1 · Cited by 60
Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats.
Lesage, M., Gustaf, E., Dufek, M., & Pentel, P. (2006) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2006.10.012 · Cited by 59
Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos
Qiao, D., Seidler, F. J., Violin, J. D., & Slotkin, T. A. (2003) · Developmental Brain Research · doi:10.1016/s0165-3806(03)00222-0 · Cited by 59
SMOKING IN PREGNANCY AND SUBSEQUENT DEVELOPMENT OF THE CHILD
Fogelman, K. (1980) · Child Care Health and Development · doi:10.1111/j.1365-2214.1980.tb00154.x · Cited by 59
Regulation of Brain Nicotinic Receptors by Chronic Agonist Infusion
Bhat, R. V., Turner, S. L., Selvaag, S., Marks, M. J., & Collins, A. C. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb03450.x · Cited by 59
Prenatal nicotine increases testosterone levels in the fetus and female offspring
Smith, L., Cloak, C. C., Poland, R. E., Torday, J. S., & Ross, M. (2003) · Nicotine & Tobacco Research · doi:10.1080/146222031000094196 · Cited by 58
Sex-dependent biological changes following prenatal nicotine exposure in the rat
Peters, D. A. V., & Tang, S. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90497-x · Cited by 58
A Comparative Study of the Effects of the Intravenous Self-Administration or Subcutaneous Minipump Infusion of Nicotine on the Expression of Brain Neuronal Nicotinic Receptor Subtypes
Moretti, M., Mugnaini, M., Tessari, M., Zoli, M., Gaimarri, A., Manfredi, I., Pistillo, F., Clementi, F., & Gotti, C. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.064071 · Cited by 58
Behavioral effects of prenatal exposure to nicotine in guinea pigs.
Jm, J., Tm, L., BECKER, R. F., & Lw, M. (1982) · PubMed · Cited by 58
Long-term behavioral and developmental consequences of pre- and perinatal nicotine
Eppolito, A. K., & Smith, R. F. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.11.020 · Cited by 56
Maternal smoking during pregnancy predicts nicotine disorder (dependence or withdrawal) in young adults - a birth cohort study
O'Callaghan, F. V., Al Mamun, A., O'Callaghan, M., Alati, R., Najman, J. M., Williams, G. M., & Bor, W. (2009) · Australian and New Zealand Journal of Public Health · doi:10.1111/j.1753-6405.2009.00410.x · Cited by 56
Prenatal Nicotine Exposure
Tizabi, Y., Russell, L. T., Nespor, S. M., Perry, D. C., & Grunberg, N. E. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00171-4 · Cited by 55
Locomotor behavioral effects of prenatal and postnatal nicotine exposure in rat offspring.
Newman, M., Shytle, R., & Sanberg, P. R. (1999) · Behavioural Pharmacology · doi:10.1097/00008877-199911000-00017 · Cited by 55
Prenatal exposure of rats to nicotine causes persistent alterations of nicotinic cholinergic receptors
Gold, A. B., Keller, A. B., & Perry, D. C. (2008) · Brain Research · doi:10.1016/j.brainres.2008.10.076 · Cited by 55
Adrenal-mediated rather than direct effects of nicotine as a basis of altered sex steroid synthesis in fetal and neonatal rat
Sarasin, A. (2003) · Reproductive Toxicology · doi:10.1016/s0890-6238(02)00119-3 · Cited by 55
Longitudinal analysis of the effect of prenatal nicotine exposure on subsequent smoking behavior of offspring
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Authors: Sobrian, S. K., & Holson, R. R.
Affiliations: Howard University (US)
Corresponding author: Sobrian, S. K.
Venue: ILAR Journal
Publisher: Oxford University Press (OUP)
Published: 2011-01-01
Volume: 52
Issue: 3
Pages: 251-294
ISSN: 1084-2020 (ISSN-L)
DOI: 10.1093/ilar.52.3.251
OpenAlex: W2145815038
Cited by: 8
References: 262
Citations by year: 2026: 3 · 2019: 1 · 2017: 1 · 2016: 2
FWCI: 0.05
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: ILAR Journal (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: prenatal nicotine exposure, maternal smoking, low birth weight, hyperactivity, cognitive impairment, learning and memory, psychiatric symptoms, nicotine self-administration, cholinergic mechanisms, sexual dimorphism, rodent models, translational research, replicability
MeSH terms: Animals, Humans, Learning, Memory, Nicotine, Prenatal Exposure Delayed Effects

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Effects of pre-and neonatal nicotine exposure in rodents: inconsistent evidence

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