The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Environmental Epigenetics and Its Implication on Disease Risk and Health Outcomes
Open accessAbstract
This review focuses on how environmental factors through epigenetics modify disease risk and health outcomes. Major epigenetic events, such as histone modifications, DNA methylation, and microRNA expression, are described. The function of dose, duration, composition, and window of exposure in remodeling the individual's epigenetic terrain and disease susceptibility are addressed. The ideas of lifelong editing of early-life epigenetic memories, transgenerational effects through germline transmission, and the potential role of hydroxylmethylation of cytosine in developmental reprogramming are discussed. Finally, the epigenetic effects of several major classes of environmental factors are reviewed in the context of pathogenesis of disease. These include endocrine disruptors, tobacco smoke, polycyclic aromatic hydrocarbons, infectious pathogens, particulate matter, diesel exhaust particles, dust mites, fungi, heavy metals, and other indoor and outdoor pollutants. We conclude that the summation of epigenetic modifications induced by multiple environmental exposures, accumulated over time, represented as broad or narrow, acute or chronic, developmental or lifelong, may provide a more precise assessment of risk and consequences. Future investigations may focus on their use as readouts or biomarkers of the totality of past exposure for the prediction of future disease risk and the prescription of effective countermeasures.
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Cites
Effect of In Utero and Early-Life Conditions on Adult Health and Disease
Gluckman, P. D., Hanson, M. A., Cooper, C., & Thornburg, K. L. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0708473 · Cited by 3,898
Epigenetic differences arise during the lifetime of monozygotic twins
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Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
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Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
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The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
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Epigenetics and the environment: emerging patterns and implications
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Developmental plasticity and human health
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“Cotreatment with a methyl donor of a phytoestrogen was able to reverse its epigenetic effects (Dolinoy et al. 2007).”
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EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
Pollution and health: a progress update
Fuller, R., Landrigan, P. J., Balakrishnan, K., Bathan, G., Bose-O'Reilly, S., Brauer, M., Caravanos, J., Chiles, T., Cohen, A., Corra, L., et al. (2022) · The Lancet Planetary Health · doi:10.1016/s2542-5196(22)00090-0 · Cited by 2,143
A review of the carcinogenic potential of bisphenol A
Seachrist, D. D., Bonk, K. W., Ho, S.-M., Prins, G. S., Soto, A. M., & Keri, R. A. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2015.09.006 · Cited by 490
Self-citationSystems Toxicology: From Basic Research to Risk Assessment
Sturla, S. J., Boobis, A. R., FitzGerald, R. E., Hoeng, J., Kavlock, R. J., Schirmer, K., Whelan, M., Wilks, M. F., & Peitsch, M. C. (2014) · Chemical Research in Toxicology · doi:10.1021/tx400410s · Cited by 366
The Importance of the Biological Impact of Exposure to the Concept of the Exposome
Dennis, K. K., Auerbach, S. S., Balshaw, D. M., Cui, Y., Fallin, M. D., Smith, M. T., Spira, A., Sumner, S., & Miller, G. W. (2016) · Environmental Health Perspectives · doi:10.1289/ehp140 · Cited by 103
Metadata
- Authors
- Ho, S.-M., Johnson, A., Tarapore, P., Janakiram, V., Zhang, X., & Leung, Y.-K.
- Venue
- ILAR Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-12-01
- Volume
- 53
- Issue
- 3-4
- Pages
- 289-305
- ISSN
- 1084-2020 (ISSN-L)
- OpenAlex
- W2093056723
- Cited by
- 312
- References
- 23
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ho, S.-M., Johnson, A., Tarapore, P., Janakiram, V., Zhang, X., & Leung, Y.-K. (2012). Environmental Epigenetics and Its Implication on Disease Risk and Health Outcomes. ILAR Journal. https://doi.org/10.1093/ilar.53.3-4.289
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
