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Prevalence of Antibodies in Human Sera against JC Virus, an Isolate from a Case of Progressive Multifocal Leukoencephalopathy
Abstract
Sera from 406 people of various ages throughout the state of Wisconsin were assayed for antibodies against IC virus, a new human papova-like virus isolated from a patient with progressive multifocal leukoencephalopathy. The hemagglutination-inhibition (HAl) test was used after it was determined that a linear relationship existed between the titers of HAI and neutralizing antibodies in human sera. About 69% (191/277) of the adults tested had significant levels of antibodies against IC virus in their serum. The highest rate of conversion to seropositivity occurred during the first 14 years of life. No sex difference in the incidence of antibodies against IC virus was found.
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Cites
Amino acid metabolism in Mammalian cell cultures
Eagle, H. (1959) · Science · doi:10.1126/science.130.3373.432 · Cited by 4,011
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Sandborn, W. J., Feagan, B. G., Rutgeerts, P., Hanauer, S., Colombel, J.-F., Sands, B. E., Lukas, M., Fedorak, R. N., Lee, S., Bressler, B., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1215739 · Cited by 2,719
Knowles, W. A., Pipkin, P., Andrews, N., Vyse, A., Minor, P., Brown, D. W. G., & Miller, E. (2003) · Journal of Medical Virology · doi:10.1002/jmv.10450 · Cited by 586
Chesters, P. M., Heritage, J., & McCance, D. J. (1983) · Journal of Infectious Diseases · doi:10.1093/infdis/147.4.676 · Cited by 532
Monaco, M. C., Atwood, W. J., Gravell, M., Tornatore, C. S., & Major, E. O. (1996) · Journal of Virology · doi:10.1128/jvi.70.10.7004-7012.1996 · Cited by 293
Metadata
- Authors
- Padgett, B. L., & Walker, D. L.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1973-04-01
- Volume
- 127
- Issue
- 4
- Pages
- 467-470
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2056695829
- Cited by
- 479
- References
- 1
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Prevalence of Antibodies in Human Sera against JC Virus, an Isolate from a Case of Progressive Multifocal Leukoencephalopathy. https://app.cochat.ai/papers/10.1093/infdis/127.4.467
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- Padgett, B. L., & Walker, D. L. (1973). Prevalence of Antibodies in Human Sera against JC Virus, an Isolate from a Case of Progressive Multifocal Leukoencephalopathy. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/127.4.467
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.