The DOI matches its Crossref record.
Infection with Herpes Simplex Virus and Cell-Mediated Immunity after Marrow Transplant
Abstract
The relationship between herpes simplex virus (HSV) infection and specific cell-mediated immunity was investigated in 141 patients before and for the first four months after marrow transplant. Sixty-two (82%) of 76 seropositive patients but only one of 65 seronegative patients developed HSV infection. Lymphocyte responses to HSV antigen were suppressed immediately after transplant and subsequently became reactive in those patients with HSV infection. The presence or absence of antibody to HSV in the donor before transplant did not influence the response. Seventy long-term survivors of marrow transplant were also studied. Among 60 patients who had pretransplant serum available for study, 26 (68%) of 38 who had been seropositive before transplant had positive responses compared with none of 22 who had been seronegative. Recovery of responsiveness to HSV antigen after marrow transplant is primarily related to recurrent virus infection and not to the pretransplant immune status of the donor.
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Cited by
Nonbacterial Pneumonia After Allogeneic Marrow Transplantation: A Review of Ten Years' Experience
Meyers, J. D., Flournoy, N., & Thomas, E. D. (1982) · Clinical Infectious Diseases · doi:10.1093/clinids/4.6.1119 · Cited by 522
Self-citationWADE, J. C., NEWTON, B., McLAREN, C., FLOURNOY, N., KEENEY, R. E., & MEYERS, J. D. (1982) · Annals of Internal Medicine · doi:10.7326/0003-4819-96-3-265 · Cited by 329
Self-citationKulshreshtha, G., Burlot, A.-S., Marty, C., Critchley, A., Hafting, J., Bedoux, G., Bourgougnon, N., & Prithiviraj, B. (2015) · Marine Drugs · doi:10.3390/md13010558 · Cited by 100
“HSV-associated diseases are also recurrent in allogeneic bone marrow patients (70%–80%) and solid organ transplant patients (32%–53%) [11,12].”
Metadata
- Authors
- Meyers, J. D., Flournoy, N., & Thomas, E. D.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1980-09-01
- Volume
- 142
- Issue
- 3
- Pages
- 338-346
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W1967027894
- Cited by
- 232
- References
- 0
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Infection with Herpes Simplex Virus and Cell-Mediated Immunity after Marrow Transplant. https://app.cochat.ai/papers/10.1093/infdis/142.3.338
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- Meyers, J. D., Flournoy, N., & Thomas, E. D. (1980). Infection with Herpes Simplex Virus and Cell-Mediated Immunity after Marrow Transplant. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/142.3.338
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
