The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Intravenous Acyclovir to Treat Mucocutaneous Herpes Simplex Virus Infection After Marrow Transplantation: A Double-Blind Trial
Abstract
Acyclovir, a new antiviral agent, was compared to a placebo in a randomized double-blind trial of treatment for culture-proven herpes simplex virus infection after marrow transplantation. Patients received either intravenous acyclovir at 750 mg/m2 body surface area per day or a placebo for 7 days. Thirteen of 17 patients given acyclovir had a beneficial response as compared with two of 17 given the placebo (p less than 0.01). The duration of positive cultures was shorter among acyclovir recipients (3 versus 17 days, p less than 0.00005). Also shorter were the median days to resolution of pain (10 versus 16 days, p = 0.03), to crusting of lesions (7 versus 14 days, p = 0.01), and to total healing (14 versus 28 days, p = 0.03). No acyclovir toxicity was observed. Recurrent infection was common. Acyclovir provided significant antiviral and clinical efficacy without toxicity in highly immunosuppressed patients but had no effect on virus latency.
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Cites
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Vidarabine Therapy of Neonatal Herpes Simplex Virus Infection
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Cited by
The purine path to chemotherapy
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ACYCLOVIR VERSUS VIDARABINE IN HERPES SIMPLEX ENCEPHALITIS
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Nonbacterial Pneumonia After Allogeneic Marrow Transplantation: A Review of Ten Years' Experience
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Metadata
- Authors
- WADE, J. C., NEWTON, B., McLAREN, C., FLOURNOY, N., KEENEY, R. E., & MEYERS, J. D.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1982-03-01
- Volume
- 96
- Issue
- 3
- Pages
- 265-269
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2044738352
- Cited by
- 329
- References
- 16
- FWCI
- 46.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Intravenous Acyclovir to Treat Mucocutaneous Herpes Simplex Virus Infection After Marrow Transplantation: A Double-Blind Trial. https://app.cochat.ai/papers/10.7326/0003-4819-96-3-265
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- WADE, J. C., NEWTON, B., McLAREN, C., FLOURNOY, N., KEENEY, R. E., & MEYERS, J. D. (1982). Intravenous Acyclovir to Treat Mucocutaneous Herpes Simplex Virus Infection After Marrow Transplantation: A Double-Blind Trial. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-96-3-265
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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