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Herpes Simplex Virus Encephalitis: Laboratory Evaluations and Their Diagnostic Significance
Abstract
Laboratory procedures were compared with brain biopsy findings in 113 biopsy-proven patients with herpes simplex virus (HSV) encephalitis and 93 biopsy-negative individuals. Examinations of brain tissue by histopathology, immunofluorescence, and electron microscopy demonstrated evidence of HSV infection in 56%, 70%, and 45% of proven cases and apparently false-positive results in 14%, 9% and 2% of those biopsy-negative. Serologic assessments revealed that HSV encephalitis occurred as both a primary (30%) and recurrent (70%) infection. Among patients with HSV encephalitis, 28% failed to seroconvert or seroboost within one month of the onset of disease. Titers of passive hemagglutinating and IgG immunofluorescent antibodies increased fourfold in the cerebrospinal fluid in 74% and 94%, respectively, of patients with proven disease. Similar percentages of patients had antibody ratios in serum and cerebrospinal fluid of less than 20 over the same interval. These data indicate the need for development of noninvasive diagnostic procedures.
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Cited by
ACYCLOVIR VERSUS VIDARABINE IN HERPES SIMPLEX ENCEPHALITIS
Sköldenberg, B., Alestig, K., Burman, L., Forkman, A., Lövgren, K., Norrby, R., Stiernstedt, G., Forsgren, M., Bergström, T., Dahlqvist, E., et al. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92623-0 · Cited by 610
(2014) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-53488-0.00011-0 · Cited by 474
Etiology of aseptic meningitis and encephalitis in an adult population
Kupila, L., Vuorinen, T., Vainionpää, R., Hukkanen, V., Marttila, R. J., & Kotilainen, P. (2006) · Neurology · doi:10.1212/01.wnl.0000191407.81333.00 · Cited by 388
Cinque, P., Cleator, G. M., Weber, T., Monteyne, P., Sindic, C. J., & van Loon, A. M. (1996) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.61.4.339 · Cited by 261
Pietrini, V, Nertempi, P., Vaglia, A., Revello, M. G., Pinna, V, & Ferro-Milone, F. (1988) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.51.10.1284 · Cited by 169
Metadata
- Authors
- Nahmias, A. J., Whitley, R. J., Visintine, A. N., Takei, Y., Alford, C. A., & Collaborative Antiviral Study Group
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1982-06-01
- Volume
- 145
- Issue
- 6
- Pages
- 829-836
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2127313546
- Cited by
- 381
- References
- 0
- FWCI
- 19.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nahmias, A. J., Whitley, R. J., Visintine, A. N., Takei, Y., Alford, C. A., & Collaborative Antiviral Study Group. (1982). Herpes Simplex Virus Encephalitis: Laboratory Evaluations and Their Diagnostic Significance. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/145.6.829
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