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Effect of Morphine on Resistance to Infection
Abstract
Morphine was demonstrated to exacerbate infections. Experiments were performed to evaluate variations of phagocytic physiology during morphine treatment. In mice, morphine drastically reduced reticuloendothelial system activity, phagocyte count, phagocytic index, killing properties, and superoxide anion production in polymorphonuclear leukocytes and macrophages. Similar effects on alveolar macrophage count, phagocytosis, and killing were found in rabbits, a result which suggested a lack of species specificity. Additional experiments demonstrated that morphine (1) induces a reduction of lymphoid organ weight, (2) impairs the ability to eradicate infections and (3) is counteracted in its depressing activity on phagocytic physiology by small amounts of Corynebacterium parvum. The results suggest that there is a close relationship between the fact that morphine exacerbates infections and the fact that morphine depresses phagocytic functions; therefore, the negative effect of morphine on phagocytosis is at least one of the reasons for its negative effect on the development of infections.
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Cited by
Roy, S., Ninkovic, J., Banerjee, S., Charboneau, R. G., Das, S., Dutta, R., Kirchner, V. A., Koodie, L., Ma, J., Meng, J., et al. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9292-5 · Cited by 309
The role of opioid receptors in immune system function
Eisenstein, T. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02904 · Cited by 286
Opioid modulation of immune responses: effects on phagocyte and lymphoid cell populations
Eisenstein, T. K., & Hilburger, M. E. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00219-1 · Cited by 262
COMPARISON OF PROPOFOL AND MIDAZOLAM FOR SEDATION IN CRITICALLY ILL PATIENTS
Aitkenhead, A., Willatts, S., Park, G., Collins, C., Ledingham, I., Pepperman, M., David Coates, P., Bodenham, A., Smith, M., & Wallace, P. M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90770-8 · Cited by 213
Role of the mu-opioid receptor in opioid modulation of immune function
Ninković, J., & Roy, S. (2013) · Amino Acids · doi:10.1007/s00726-011-1163-0 · Cited by 196
Metadata
- Authors
- Tubaro, E., Borelli, G., Croce, C., Cavallo, G., & Santiangeli, C.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1983-10-01
- Volume
- 148
- Issue
- 4
- Pages
- 656-666
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2084183229
- Cited by
- 280
- References
- 0
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effect of Morphine on Resistance to Infection. https://app.cochat.ai/papers/10.1093/infdis/148.4.656
- The paper
- Tubaro, E., Borelli, G., Croce, C., Cavallo, G., & Santiangeli, C. (1983). Effect of Morphine on Resistance to Infection. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/148.4.656
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
