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Antibody-Dependent Cell-Mediated Cytotoxicity Against Influenza Virus-Infected Cells
Abstract
The three major immunocompetent cells in human peripheral blood (lymphocytes, neutrophils, and monocytes) were shown to be effector cells for antibody-dependent cell-mediated cytotoxicity (ADCC) against influenza virus-infected baby hamster kidney cells in vitro. Lymphocyte cytotoxicity was mediated by FcIgG receptor-bearing null cells and T gamma cells. These effector populations were best defined by HNK-1, a monoclonal antibody to human natural killer and ADCC-mediator cells. Antibody responsible for ADCC against influenza virus-infected cells was detectable in sera of young children after natural infection and after vaccination with inactivated and live attenuated viruses. ADCC antibody appeared before hemagglutination-inhibiting antibody and persisted for at least one year after vaccination with live attenuated vaccine. ADCC antibody was subtype-specific but quite broadly reactive within a subtype. Both hemagglutinin and neuraminidase were antigenic determinants for ADCC antibody. An anamnestic response to the original strain was observed after challenge with influenza virus of a heterologous subtype.
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Citations
Cited by
Control of Human Viral Infections by Natural Killer Cells
Jost, S., & Altfeld, M. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100001 · Cited by 458
Gómez-Román, V. R., Patterson, L. J., Venzon, D., Liewehr, D., Aldrich, K., Florese, R., & Robert-Guroff, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2185 · Cited by 276
Jegaskanda, S., Laurie, K. L., Amarasena, T. H., Winnall, W. R., Kramski, M., De Rose, R., Barr, I. G., Brooks, A. G., Reading, P. C., & Kent, S. J. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit294 · Cited by 64
Humoral immune responses to AAV gene therapy in the ocular compartment
Whitehead, M., Osborne, A., Yu‐Wai‐Man, P., & Martin, K. (2021) · Biological Reviews · doi:10.1111/brv.12718 · Cited by 52
Metadata
- Authors
- Hashimoto, G., Wright, P. F., & Karzon, D. T.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1983-11-01
- Volume
- 148
- Issue
- 5
- Pages
- 785-794
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2105337546
- Cited by
- 162
- References
- 0
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hashimoto, G., Wright, P. F., & Karzon, D. T. (1983). Antibody-Dependent Cell-Mediated Cytotoxicity Against Influenza Virus-Infected Cells. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/148.5.785
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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