Age-Associated Cross-reactive Antibody-Dependent Cellular Cytotoxicity Toward 2009 Pandemic Influenza A Virus Subtype H1N1
Open accessAbstract
BACKGROUND: During the 2009 pandemic of influenza A virus subtype H1N1 (A[H1N1]pdm09) infection, older individuals were partially protected from severe disease. It is not known whether preexisting antibodies with effector functions such as antibody-dependent cellular cytotoxicity (ADCC) contributed to the immunity observed. METHODS: We tested serum specimens obtained from 182 individuals aged 1-72 years that were collected either immediately before or after the A(H1N1)pdm09 pandemic for ADCC antibodies to the A(H1N1)pdm09 hemagglutinin (HA) protein. RESULTS: A(H1N1)pdm09 HA-specific ADCC antibodies were detected in almost all individuals aged >45 years (28/31 subjects) before the 2009 A(H1N1) pandemic. Conversely, only approximately half of the individuals aged 1-14 years (11/31) and 15-45 years (17/31) had cross-reactive ADCC antibodies before the 2009 A(H1N1) pandemic. The A(H1N1)pdm09-specific ADCC antibodies were able to efficiently mediate the killing of influenza virus-infected respiratory epithelial cells. Further, subjects >45 years of age had higher ADCC titers to a range of seasonal H1N1 HA proteins, including from the 1918 virus, compared with younger individuals. CONCLUSIONS: ADCC antibodies may have contributed to the protection exhibited in older individuals during the 2009 A(H1N1) pandemic. This work has significant implications for improved vaccination strategies for future influenza pandemics.
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ADCC is mainly mediated by the interaction between virus-specific antibodies and Fcγ receptor IIIα (FcγRIIIα, CD16), which is present on NK cells.
“ADCC is mainly mediated by the interaction between virus-specific antibodies and Fcγ receptor IIIα (FcγRIIIα, CD16), which is, for example, present on NK cells (61–63).”
From SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients (2021) · cites this paper as [63]
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- Authors
- Jegaskanda, S., Laurie, K. L., Amarasena, T. H., Winnall, W. R., Kramski, M., De Rose, R., Barr, I. G., Brooks, A. G., Reading, P. C., & Kent, S. J.
- Affiliations
- The University of Melbourne (AU)
- Victorian Infectious Diseases Reference Laboratory (AU)
- Corresponding author
- Jegaskanda, Sinthujan
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-06-28
- Volume
- 208
- Issue
- 7
- Pages
- 1051-1061
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2102497131
- Cited by
- 64
- References
- 39
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 10 · 2016: 14 · 2015: 2 · 2014: 4 · 2013: 3
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- The Journal of Infectious Diseases (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- antibody-dependent cellular cytotoxicity, 2009 H1N1 pandemic, pre-existing immunity, cross-reactive antibodies, age-related immunity, hemagglutinin, seasonal H1N1, 1918 influenza, airway epithelial cells, older adults
- MeSH terms
- Adolescent, Adult, Age Factors, Antibodies, Viral, Antibody-Dependent Cell Cytotoxicity, Child, Child, Preschool, Female, Humans, Infant, Influenza, Human, Male, Middle Aged, Influenza A Virus, H1N1 Subtype, Young Adult
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