The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Vaccine-Elicited Antibodies Mediate Antibody-Dependent Cellular Cytotoxicity Correlated with Significantly Reduced Acute Viremia in Rhesus Macaques Challenged with SIVmac251
Abstract
Effector cells armed with Abs can eliminate virus-infected target cells by Ab-dependent cellular cytotoxicity (ADCC), an immune mechanism that has been largely overlooked in HIV vaccine development. Here, we show that a prime/boost AIDS vaccine approach elicits potent ADCC activity correlating with protection against SIV in rhesus macaques (Macacca mulatta). Priming with replicating adenovirus type 5 host range mutant-SIV recombinants, followed by boosting with SIV gp120, elicited Abs with ADCC activity against SIVmac251-infected cells. In vitro ADCC activity correlated with in vivo reduced acute viremia after a mucosal challenge with pathogenic SIV. Our findings expose ADCC activity as an immune correlate that may be relevant in the rational design of an efficacious vaccine against HIV.
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Cites
Transmission, acute HIV-1 infection and the quest for strategies to prevent infection
Pope, M., & Haase, A. T. (2003) · Nature Medicine · doi:10.1038/nm0703-847 · Cited by 355
(1990) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-11888-5 · Cited by 261
Patterson, L. J., Malkevitch, N., Venzon, D., Pinczewski, J., Gómez-Román, V. R., Wang, L., Kalyanaraman, V. S., Markham, P. D., Robey, F. A., & Robert-Guroff, M. (2004) · Journal of Virology · doi:10.1128/jvi.78.5.2212-2221.2004 · Cited by 172
Self-citationA novel technique for the fluorometric assessment of T lymphocyte antigen specific lysis
Sheehy, M. E., McDermott, A. B., Furlan, S. N., Klenerman, P., & Nixon, D. F. (2001) · Journal of Immunological Methods · doi:10.1016/s0022-1759(00)00329-x · Cited by 166
Antibody-Dependent Cell-Mediated Cytotoxicity Against Influenza Virus-Infected Cells
Hashimoto, G., Wright, P. F., & Karzon, D. T. (1983) · Journal of Infectious Diseases · doi:10.1093/infdis/148.5.785 · Cited by 162
Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization
Lubeck, M. D., Natuk, R. J., Myagkikh, M., Kalyan, N. K., Aldrich, K., Sinangil, F., Alipanah, S., MURTHY, S. C. S., Chanda, P. K., Nigida, S. M., et al. (1997) · Nature Medicine · doi:10.1038/nm0697-651 · Cited by 152
Self-citationAmara, R. R., Smith, J. M., Staprans, S. I., Montefiori, D. C., Villinger, F. J., Altman, J. D., O’Neil, S. P., Kozyr, N. L., Xu, Y., Wyatt, L. S., et al. (2002) · Journal of Virology · doi:10.1128/jvi.76.12.6138-6146.2002 · Cited by 151
Heterologous Envelope Immunogens Contribute to AIDS Vaccine Protection in Rhesus Monkeys
Letvin, N. L., Huang, Y., Chakrabarti, B. K., Xu, L., Seaman, M. S., Beaudry, K. R., Korioth-Schmitz, B., Yu, F. H., Rohne, D., Martin, K. L., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.14.7490-7497.2004 · Cited by 131
Buge, S. L., Richardson, E. S., Alipanah, S., Markham, P. D., Cheng, S., Kalyan, N. K., Miller, C. J., Lubeck, M. D., Udem, S. A., Eldridge, J. H., et al. (1997) · Journal of Virology · doi:10.1128/jvi.71.11.8531-8541.1997 · Cited by 126
Self-citationGiavedoni, L. D., Velasquillo, M. C., Parodi, L. M., Hubbard, G. B., & Hodara, V. L. (2000) · Journal of Virology · doi:10.1128/jvi.74.4.1648-1657.2000 · Cited by 120
Cited by
Bonsignori, M., Pollara, J., Moody, M. A., Alpert, M. D., Chen, X., Hwang, K.-K., Gilbert, P. B., Huang, Y., Gurley, T. C., Kozink, D. M., et al. (2012) · Journal of Virology · doi:10.1128/jvi.01023-12 · Cited by 375
Lambotte, O., Ferrari, G., Moog, C., Yates, N. L., Liao, H.-X., Parks, R. J., Hicks, C. B., Owzar, K., Tomaras, G. D., Montefiori, D. C., et al. (2009) · AIDS · doi:10.1097/qad.0b013e328329f97d · Cited by 342
Replicating and non-replicating viral vectors for vaccine development
Robert-Guroff, M. (2007) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2007.10.010 · Cited by 275
Self-citationBarnett, S. W., Burke, B., Sun, Y., Kan, E., Legg, H., Lian, Y., Bost, K., Zhou, F., Goodsell, A., zur Megede, J., et al. (2010) · Journal of Virology · doi:10.1128/jvi.02533-09 · Cited by 82
Metadata
- Authors
- Gómez-Román, V. R., Patterson, L. J., Venzon, D., Liewehr, D., Aldrich, K., Florese, R., & Robert-Guroff, M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-02
- Volume
- 174
- Issue
- 4
- Pages
- 2185-2189
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1529373421
- Cited by
- 276
- References
- 22
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Vaccine-Elicited Antibodies Mediate Antibody-Dependent Cellular Cytotoxicity Correlated with Significantly Reduced Acute Viremia in Rhesus Macaques Challenged with SIVmac251. https://app.cochat.ai/papers/10.4049/jimmunol.174.4.2185
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- Gómez-Román, V. R., Patterson, L. J., Venzon, D., Liewehr, D., Aldrich, K., Florese, R., & Robert-Guroff, M. (2005). Vaccine-Elicited Antibodies Mediate Antibody-Dependent Cellular Cytotoxicity Correlated with Significantly Reduced Acute Viremia in Rhesus Macaques Challenged with SIVmac251. The Journal of Immunology. https://doi.org/10.4049/jimmunol.174.4.2185
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