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Cachectin: More Than a Tumor Necrosis Factor

Epstein, Franklin H., Beutler, Bruce, Cerami, Anthony·1987·New England Journal of Medicine
DOI 10.1056/nejm198702123160705
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Abstract

THE metabolic impact of infectious and neoplastic disease states has long been known to clinicians.1 2 3 4 Invasive diseases may disrupt normal homeo-static mechanisms, both locally and systemically. For example, acute gram-negative infections frequently lead to profound metabolic acidosis and to biphasic changes in plasma glucose concentration, both seen in the context of hypotension, disseminated intravascular coagulation, and widespread tissue injury.5 6 7 8 9 10 11 12 Chronic infectious diseases, as well as neoplastic diseases, may provoke a severe wasting diathesis, in which negative calorie and nitrogen balance lead to death despite the absence of a large parasite or tumor burden.It was once widely believed that invasive . . .

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Metadata

Authors
Epstein, F. H., Beutler, B., & Cerami, A.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1987-02-12
Volume
316
Issue
7
Pages
379-385
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198702123160705
OpenAlex
W2048540725
Cited by
1,432
References
2
FWCI
171.36
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Cachectin: More Than a Tumor Necrosis Factor. https://app.cochat.ai/papers/10.1056/nejm198702123160705
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Epstein, F. H., Beutler, B., & Cerami, A. (1987). Cachectin: More Than a Tumor Necrosis Factor. New England Journal of Medicine. https://doi.org/10.1056/nejm198702123160705

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