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Cited by 175Ear Surgery and Otitis MediaBacterial Infections and VaccinesMicrobial infections and disease research

Epidemiology of Moraxella catarrhalis in children during the first 2 years of life: relationship to otitis media.

Faden, H., Harabuchi, Y., Hong, J. J., Tonawanda/Williamsville Pediatrics·1994·Journal of Infectious Diseases
DOI 10.1093/infdis/169.6.1312
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Abstract

Nasopharyngeal colonization with Moraxella catarrhalis was evaluated in a large cohort of infants followed prospectively from birth to 2 years of age; 120 children were examined at 13 routine visits. Of these, 66% became colonized with M. catarrhalis by 1 year and 77.5% by 2 years. Nasopharyngeal colonization with M. catarrhalis increased from 27.0% during healthy visits to 62.7% during visits due to otitis media (P < .001). Otitis-prone children were colonized at 44.4% of all visits compared with 16.7% for children who did not have otitis media (P < .001). DNA from 112 strains of M. catarrhalis from 34 children were evaluated; 106 were successfully digested with restriction enzymes and demonstrated a great degree of heterogeneity. Children tended to acquire and eliminate a number of different strains. Intrafamilial spread of the same strain of M. catarrhalis was frequent. These data suggest that nasopharyngeal colonization with M. catarrhalis is common throughout infancy. A high rate of colonization is associated with an increased risk of otitis media.

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Crossref · 10.1093/infdis/169.6.1312

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  • M. catarrhalis is now acknowledged as the third most common cause of otitis media after S. pneumoniae and H. influenzae, and the second most common cause of exacerbations in COPD, accounting for up to 4 million exacerbations per year in the United States alone.

    “Moraxella catarrhalis is a bacteria of increasing importance being now acknowledged as the third most common cause of otitis media (OM), after S. pneumoniae and H. influenzae (Bluestone, 1986; Faden et al., 1994; Kilpi et al., 2001; Dupont et al., 2010) and the second most common cause of exacerbations in COPD, accounting for up to 4 million exacerbations per year in the United States alone (Mur”

    From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Faden et al., 1994

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Authors
Faden, H., Harabuchi, Y., Hong, J. J., & Pediatrics, T.
Affiliations
State University of New York (US)
Corresponding author
Faden, H.
ORCID
Venue
Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
1994-06-01
Volume
169
Issue
6
Pages
1312-1317
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1093/infdis/169.6.1312
OpenAlex
W1994988080
Cited by
175
References
25
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 1 · 2020: 1 · 2019: 4 · 2017: 4 · 2016: 5 · 2015: 8 · 2014: 8 · 2013: 5 · 2012: 5
FWCI
7.78
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ai015939-17, 5r01hd019679-09)
  • National Institute of Allergy and Infectious Diseases (AI 15939)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-19679)
Topics
  • Health Sciences › Medicine › Otorhinolaryngology › Ear Surgery and Otitis Media
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
  • Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
Keywords
Moraxella catarrhalis, nasopharyngeal carriage, otitis media, infants, otitis-prone children, household transmission
MeSH terms
Moraxella catarrhalis, Child, Preschool, Demography, DNA, Bacterial, Humans, Infant, Nasopharynx, Otitis Media, Risk Factors, Deoxyribonucleases, Type II Site-Specific, Cohort Studies, Neisseriaceae Infections

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