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The Impact Of Conjugate Vaccine On Carriage Of Haemophilus Influenzae Type B
Abstract
Conjugate vaccines against Haemophilus influenzae type b (Hib) may modify Hib pharyngeal colonization. Hib colonization was compared in 371 infants and their families. In Oxfordshire, infants received PRP-T (polyribosylribitol phosphate conjugated to tetanus toxoid) and in Buckinghamshire they did not (controls). Infants were followed at 6, 9, and 12 months of age. Also, 6 unvaccinated Hib carriers were vaccinated and followed for 6 weeks. Hib acquisition was lower in vaccinees than controls (P < .01). During surveillance, 1.5% of vaccinees and 6.3% of controls carried Hib (P = .04). Among those with family Hib exposure, the carriage rates were 8.7% and 38.5% (P = .07), respectively. Hiv carriage rates were lower among vaccinees' unvaccinated siblings. Giving conjugate vaccine to a child carrying Hib did not rapidly terminate carriage. Thus, a primary means by which herd immunity to Hib is induced in a vaccinated population may be through reduction or delay in the initial acquisition of Hib.
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Cited by
Dagan, R., Givon‐Lavi, N., Zamir, O., Sikuler‐Cohen, M., Guy, L., Janco, J., Yagupsky, P., & Fraser, D. (2002) · The Journal of Infectious Diseases · doi:10.1086/339525 · Cited by 339
Immunology of bacterial polysaccharide antigens
Weintraub, A. (2003) · Carbohydrate Research · doi:10.1016/j.carres.2003.07.008 · Cited by 310
Wu, H.-Y., & Russell, M. W. (1997) · Immunologic Research · doi:10.1007/bf02786362 · Cited by 184
Cowgill, K. D., Ndiritu, M., Nyiro, J., Slack, M. P. E., Chiphatsi, S., Ismail, A., Kamau, T., Mwangi, I., English, M., Newton, C. R. J. C., et al. (2006) · JAMA · doi:10.1001/jama.296.6.671 · Cited by 183
Meningococcal C conjugate vaccine: the experience in England and Wales
Campbell, H., Borrow, R., Salisbury, D., & Miller, E. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.04.067 · Cited by 168
Metadata
- Authors
- Barbour, M. L., Mayon-White, R. T., Coles, C., Crook, D. W. M., & Moxon, E. R.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-01-01
- Volume
- 171
- Issue
- 1
- Pages
- 93-98
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2054843896
- Cited by
- 238
- References
- 0
- FWCI
- 9.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Barbour, M. L., Mayon-White, R. T., Coles, C., Crook, D. W. M., & Moxon, E. R. (1995). The Impact Of Conjugate Vaccine On Carriage Of Haemophilus Influenzae Type B. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/171.1.93
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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