The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Diagnosis of Herpes Simplex Encephalitis: Application of Polymerase Chain Reaction to Cerebrospinal Fluid from Brain-Biopsied Patients and Correlation with Disease
Abstract
Isolation of herpes simplex virus (HSV) from brain tissue after biopsy has been considered the reference standard for the diagnosis of herpes simplex encephalitis (HSE). During the evaluation of antiviral treatment of HSE, cerebrospinal fluid (CSF) was obtained from patients with clinical disease indicative of HSE who underwent diagnostic brain biopsy. HSV DNA was detected by polymerase chain reaction (PCR) in CSF of 53 (98%) of 54 patients with biopsy-proven HSE and was detected in all 18 CSF specimens obtained before brain biopsy from patients with proven HSE. Four of 19 CSF specimens were positive after 2 weeks of antiviral therapy. Positive results were found in 3 (6%) of 47 patients whose brain tissue was culture-negative. Detection of HSV DNA in the CSF correlated significantly with age and focal radiographic findings. Thus, PCR detection of HSV DNA should be the standard for diagnosis of HSE.
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Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
Vidarabine versus Acyclovir Therapy in Herpes Simplex Encephalitis
Whitley, R. J., Alford, C. A., Hirsch, M. S., Schooley, R. T., Luby, J. P., Aoki, F. Y., Hanley, D., Nahmias, A. J., Soong, S.-J., & The NIAID Collaborative Antiviral Study Group* (1986) · New England Journal of Medicine · doi:10.1056/nejm198601163140303 · Cited by 896
Self-citation
Cited by
(2014) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-53488-0.00011-0 · Cited by 474
Etiology of aseptic meningitis and encephalitis in an adult population
Kupila, L., Vuorinen, T., Vainionpää, R., Hukkanen, V., Marttila, R. J., & Kotilainen, P. (2006) · Neurology · doi:10.1212/01.wnl.0000191407.81333.00 · Cited by 388
Viral encephalitis: a review of diagnostic methods and guidelines for management
Steiner, I., Budka, H., Chaudhuri, A., Koskiniemi, M., Sainio, K., Salonen, O., & Kennedy, P. G. E. (2005) · European Journal of Neurology · doi:10.1111/j.1468-1331.2005.01126.x · Cited by 367
Molecular Methods for Diagnosis of Viral Encephalitis
DeBiasi, R. L., & Tyler, K. L. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.4.903-925.2004 · Cited by 274
Herpes simplex and varicella zoster CNS infections: clinical presentations, treatments and outcomes
Kaewpoowat, Q., Salazar, L., Aguilera, E., Wootton, S. H., & Hasbun, R. (2016) · Infection · doi:10.1007/s15010-015-0867-6 · Cited by 109
Metadata
- Authors
- Lakeman, F. D., Whitley, R. J., & National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-04-01
- Volume
- 171
- Issue
- 4
- Pages
- 857-863
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2041964832
- Cited by
- 673
- References
- 2
- FWCI
- 23.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Diagnosis of Herpes Simplex Encephalitis: Application of Polymerase Chain Reaction to Cerebrospinal Fluid from Brain-Biopsied Patients and Correlation with Disease. https://app.cochat.ai/papers/10.1093/infdis/171.4.857
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- Lakeman, F. D., Whitley, R. J., & National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. (1995). Diagnosis of Herpes Simplex Encephalitis: Application of Polymerase Chain Reaction to Cerebrospinal Fluid from Brain-Biopsied Patients and Correlation with Disease. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/171.4.857
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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