The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Variation in the Tumor Necrosis Factor- Gene Promoter Region May Be Associated with Death from Meningococcal Disease
Abstract
Tumor necrosis factor-alpha (TNF-alpha) plays a central role in the pathophysiology of sepsis. Levels of TNF-alpha are directly correlated with severity in meningococcal disease (MD). A polymorphism in the promoter region of the TNF-alpha gene is associated with differences in the secretion of TNF-alpha. The TNF2 allele is associated with higher constitutive and inducible levels of TNF-alpha secretion than is the TNF1 allele. To investigate whether possession of the TNF2 allele is associated with severity in MD, the frequency of TNF1 and TNF2 alleles in 98 children with MD was compared. There were more deaths among children who had the TNF2 allele (P = .03; relative risk [RR], 2.5; 95% confidence interval [CI], 1.1-5.7) than in those who did not. There was also an increased risk of severe disease in children with the TNF2 allele (P = .02; RR, 1.6; 95% CI, 1.1-2.3). Possession of the TNF2 allele predisposes to a worse outcome in children with meningococcal infection.
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Cites
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Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria
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Cited by
Epidemiology of sepsis: an update
Angus, D. C., & Wax, R. S. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107001-00035 · Cited by 813
Human malarial disease: a consequence of inflammatory cytokine release
Clark, I. A., Budd, A. C., Alleva, L. M., & Cowden, W. B. (2006) · Malaria Journal · doi:10.1186/1475-2875-5-85 · Cited by 317
the International Meningococcal Genetics Consortium (2010) · Nature Genetics · doi:10.1038/ng.640 · Cited by 288
Is there a future for TNF promoter polymorphisms?
Bayley, J.-P., Ottenhoff, T. H. M., & Verweij, C. L. (2004) · Genes & Immunity · doi:10.1038/sj.gene.6364055 · Cited by 262
Genetic polymorphisms in sepsis
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Metadata
- Authors
- Nadel, S., Newport, M. J., Booy, R., & Levin, M.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-10-01
- Volume
- 174
- Issue
- 4
- Pages
- 878-880
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2110821910
- Cited by
- 305
- References
- 9
- FWCI
- 11.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Variation in the Tumor Necrosis Factor- Gene Promoter Region May Be Associated with Death from Meningococcal Disease. https://app.cochat.ai/papers/10.1093/infdis/174.4.878
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- Nadel, S., Newport, M. J., Booy, R., & Levin, M. (1996). Variation in the Tumor Necrosis Factor- Gene Promoter Region May Be Associated with Death from Meningococcal Disease. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/174.4.878
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
