Cited by 237SARS-CoV-2 and COVID-19 ResearchSARS-CoV-2 detection and testingCOVID-19 Clinical Research Studies

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S-Variant SARS-CoV-2 Lineage B1.1.7 Is Associated With Significantly Higher Viral Load in Samples Tested by TaqPath Polymerase Chain Reaction

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Kidd, Michael, Richter, Alex, Best, Angus, Cumley, Nicola, Mirza, Jeremy, Percival, Benita, Mayhew, Megan, Megram, Oliver, Ashford, Fiona, White, Thomas, Moles-Garcia, Emma, Crawford, Liam, Bosworth, Andrew, Atabani, Sowsan F, Plant, Tim, McNally, Alan·2021·The Journal of Infectious Diseases

DOI 10.1093/infdis/jiab082PMC PMC7928763

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Abstract

A SARS-CoV-2 variant B1.1.7 containing mutation Δ69/70 has spread rapidly in the United Kingdom and shows an identifiable profile in ThermoFisher TaqPath RT-qPCR, S gene target failure (SGTF). We analyzed recent test data for trends and significance. Linked cycle threshold (Ct) values for respiratory samples showed that a low Ct for ORF1ab and N were clearly associated with SGTF. Significantly more SGTF samples had higher inferred viral loads between 1×107 and 1×108. Our conclusion is that patients whose samples exhibit the SGTF profile are more likely to have high viral loads, which may explain higher infectivity and rapidity of spread.

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Self-citation
How to establish an academic SARS-CoV-2 testing laboratory
Richter, A. G., Plant, T. D., Kidd, M., Bosworth, A., Mayhew, M., Megram, O., Ashworth, F., Crawford, L., White, T., Moles-Garcia, E., et al. (2020) · Nature Microbiology · doi:10.1038/s41564-020-00818-3 · Cited by 22 · cited 1×
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BackgroundSelf-citation
Validation testing to determine the effectiveness of lateral flow testing for asymptomatic SARS-CoV-2 detection in low prevalence settingsPreprint
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Richter, 24, Extrapolation of United Kingdom pillar 2 care home COVID-19 test data to ascertain effectiveness of lateral flow testing in low prevalence settings, medRxiv

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Background
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Authors: Kidd, M., Richter, A., Best, A., Cumley, N., Mirza, J., Percival, B., Mayhew, M., Megram, O., Ashford, F., White, T., Moles-Garcia, E., Crawford, L., Bosworth, A., Atabani, S. F., Plant, T., & McNally, A.
Affiliations: University Hospitals Birmingham NHS Foundation Trust (GB)
University of Birmingham (GB)
Corresponding author: Kidd, Michael
ORCID: Kidd, Michael
Richter, Alex
Best, Angus
Cumley, Nicola
Mirza, Jeremy
Percival, Benita
Mayhew, Megan
Megram, Oliver
Ashford, Fiona
Crawford, Liam
Bosworth, Andrew
Atabani, Sowsan F
McNally, Alan
Venue: The Journal of Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2021-02-13
Volume: 223
Issue: 10
Pages: 1666-1670
ISSN: 0022-1899 (ISSN-L)
1537-6613
DOI: 10.1093/infdis/jiab082
PMC: PMC7928763
OpenAlex: W3128016658
Cited by: 237
References: 3
Citations by year: 2026: 3 · 2025: 8 · 2024: 12 · 2023: 31 · 2022: 67 · 2021: 116
FWCI: 17.88
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: The Journal of Infectious Diseases (publishedVersion)
medRxiv (acceptedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders: UK Department of Health and Social Care
Topics: Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords: SARS-CoV-2, B.1.1.7 variant, S-gene target failure, viral load, cycle threshold, ORF1ab, N gene, infectivity, COVID-19 diagnosis
MeSH terms: COVID-19, SARS-CoV-2, Humans, Linear Models, Polymerase Chain Reaction, Viral Load, Taq Polymerase

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S-Variant SARS-CoV-2 Lineage B1.1.7 Is Associated With Significantly Higher Viral Load in Samples Tested by TaqPath Polymerase Chain Reaction

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