The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
S-Variant SARS-CoV-2 Lineage B1.1.7 Is Associated With Significantly Higher Viral Load in Samples Tested by TaqPath Polymerase Chain Reaction
Open accessPublished version of a preprint
Abstract
A SARS-CoV-2 variant B1.1.7 containing mutation Δ69/70 has spread rapidly in the United Kingdom and shows an identifiable profile in ThermoFisher TaqPath RT-qPCR, S gene target failure (SGTF). We analyzed recent test data for trends and significance. Linked cycle threshold (Ct) values for respiratory samples showed that a low Ct for ORF1ab and N were clearly associated with SGTF. Significantly more SGTF samples had higher inferred viral loads between 1×107 and 1×108. Our conclusion is that patients whose samples exhibit the SGTF profile are more likely to have high viral loads, which may explain higher infectivity and rapidity of spread.
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“It was also associated with threefold to eightfold higher upper-airway levels [199][200][201]”
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Volz, E., Mishra, S., Chand, M., Barrett, J. C., Johnson, R., Geidelberg, L., Hinsley, W. R., Laydon, D. J., Dabrera, G., O’Toole, Á., et al. (2021) · doi:10.1101/2020.12.30.20249034 · Cited by 1,611
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Self-citationHow to establish an academic SARS-CoV-2 testing laboratory
Richter, A. G., Plant, T. D., Kidd, M., Bosworth, A., Mayhew, M., Megram, O., Ashworth, F., Crawford, L., White, T., Moles-Garcia, E., et al. (2020) · Nature Microbiology · doi:10.1038/s41564-020-00818-3 · Cited by 22 · cited 1×
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BackgroundSelf-citationFerguson, J., Dunn, S. J., Best, A., et al. (2020) · medRxiv · doi:10.1101/2020.12.01.20237784 · Cited by 17
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Metadata
- Authors
- Kidd, M., Richter, A., Best, A., Cumley, N., Mirza, J., Percival, B., Mayhew, M., Megram, O., Ashford, F., White, T., Moles-Garcia, E., Crawford, L., Bosworth, A., Atabani, S. F., Plant, T., & McNally, A.
- Affiliations
- University Hospitals Birmingham NHS Foundation Trust (GB)
- University of Birmingham (GB)
- Corresponding author
- Kidd, Michael
- ORCID
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2021-02-13
- Volume
- 223
- Issue
- 10
- Pages
- 1666-1670
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- PMC
- PMC7928763
- OpenAlex
- W3128016658
- Cited by
- 237
- References
- 3
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 12 · 2023: 31 · 2022: 67 · 2021: 116
- FWCI
- 17.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- medRxiv (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- UK Department of Health and Social Care
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- SARS-CoV-2, B.1.1.7 variant, S-gene target failure, viral load, cycle threshold, ORF1ab, N gene, infectivity, COVID-19 diagnosis
- MeSH terms
- COVID-19, SARS-CoV-2, Humans, Linear Models, Polymerase Chain Reaction, Viral Load, Taq Polymerase
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