The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Soluble CD163, a Novel Marker of Activated Macrophages, Is Elevated and Associated With Noncalcified Coronary Plaque in HIV-Infected Patients
Open accessAbstract
BACKGROUND: Pro-inflammatory monocytes/macrophages may contribute to increased atherosclerosis in human immunodeficiency virus (HIV)-infected patients. We investigate--to our knowledge, for the first time--sCD163 and other markers of monocyte activation in relationship to atherosclerotic plaque in HIV-infected patients. METHODS: One hundred two HIV-infected and 41 HIV-seronegative men with equivalent cardiovascular risk factors and without history of coronary artery disease were prospectively recruited and underwent computed tomography coronary angiography. RESULTS: sCD163 levels and presence of plaque were significantly higher among antiretroviral-treated subjects with undetectable HIV RNA levels, compared with seronegative controls (1172 ± 646 vs. 883 ± 561 ng/mL [P = .02] for sCD163 and 61% vs. 39% [P = .03] for presence of plaque). After adjusting for age, race, lipids, blood pressure, glucose, smoking, sCD14, and HIV infection, sCD163 remained independently associated with noncalcified plaque (P = .008). Among HIV-infected patients, sCD163 was associated with coronary segments with noncalcified plaque (r = 0.21; P = .04), but not with calcium score. In contrast, markers of generalized inflammation, including C-reactive protein level, and D-dimer were not associated with sCD163 or plaque among HIV-infected patients. CONCLUSIONS: sCD163, a monocyte/macrophage activation marker, is increased in association with noncalcified coronary plaque in men with chronic HIV infection and low or undetectable viremia. These data suggest a potentially important role of chronic monocyte/macrophage activation in the development of noncalcified vulnerable plaque. CLINICAL TRIAL REGISTRATION: NCT00455793.
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Cites
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Microbial translocation is a cause of systemic immune activation in chronic HIV infection
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The end of AIDS: HIV infection as a chronic disease
Deeks, S. G., Lewin, S. R., & Havlir, D. V. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61809-7 · Cited by 2,063
Systemic Effects of Inflammation on Health during Chronic HIV Infection
Deeks, S. G., Tracy, R., & Douek, D. C. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.001 · Cited by 868
National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2
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Feinstein, M. J., Hsue, P. Y., Benjamin, L. A., Bloomfield, G. S., Currier, J. S., Freiberg, M. S., Grinspoon, S. K., Levin, J., Longenecker, C. T., Post, W. S., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000695 · Cited by 658
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Metadata
- Authors
- Burdo, T. H., Lo, J., Abbara, S., Wei, J., DeLelys, M. E., Preffer, F., Rosenberg, E. S., Williams, K. C., & Grinspoon, S.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-10-15
- Volume
- 204
- Issue
- 8
- Pages
- 1227-1236
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2157969042
- Cited by
- 422
- References
- 34
- FWCI
- 37.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Burdo, T. H., Lo, J., Abbara, S., Wei, J., DeLelys, M. E., Preffer, F., Rosenberg, E. S., Williams, K. C., & Grinspoon, S. (2011). Soluble CD163, a Novel Marker of Activated Macrophages, Is Elevated and Associated With Noncalcified Coronary Plaque in HIV-Infected Patients. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jir520
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