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Cited by 72Viral Infections and Immunology ResearchVaccine Coverage and HesitancyViral gastroenteritis research and epidemiology

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Waning Intestinal Immunity After Vaccination With Oral Poliovirus Vaccines in India

Grassly, Nicholas C., Jafari, Hamid, Bahl, Sunil, Sethi, Raman, Deshpande, Jagadish M., Wolff, Chris, Sutter, Roland W., Aylward, R. Bruce·2012·The Journal of Infectious Diseases
DOI 10.1093/infdis/jis241
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Abstract

Background The eradication of wild-type polioviruses in areas with efficient fecal-oral transmission relies on intestinal mucosal immunity induced by oral poliovirus vaccine (OPV). Mucosal immunity is thought to wane over time but the rate of loss of protection has not been examined. Methods We examined the degree and duration of intestinal mucosal immunity in India by measuring the prevalence of vaccine poliovirus in stool samples collected 4-28 days after a "challenge" dose of OPV among 47 574 children with acute flaccid paralysis reported during 2005-2009. Results Previous vaccination with OPV was protective against excretion of vaccine poliovirus after challenge, but the odds of excretion increased significantly with the time since the child was last exposed to an immunization activity (odds ratio, 1.39 [95% confidence interval .99-1.97], 2.04 [1.28-3.25], and 1.31 [1.00-1.70] comparing ≥6 months with 1 month ago for serotypes 1, 2, and 3, respectively). Vaccine administered during the high season for enterovirus infections (April-September) was significantly less likely to result in excretion, especially in northern states (odds ratio, 0.57 [95% confidence interval, .50-.65], 0.58 [.41-.81], and 0.48 [.40-.57] for serotypes 1, 2, and 3). Conclusions Infection with OPV (vaccine "take") is highly seasonal in India and results in intestinal mucosal immunity that appears to wane significantly within a year of vaccination.

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Metadata

Authors
Grassly, N. C., Jafari, H., Bahl, S., Sethi, R., Deshpande, J. M., Wolff, C., Sutter, R. W., & Aylward, R. B.
Affiliations
  • Imperial College London (GB)
  • World Health Organization - India (IN)
  • World Health Organization (CH)
Corresponding author
Grassly, Nicholas C.
ORCID
Venue
The Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2012-03-23
Volume
205
Issue
10
Pages
1554-1561
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1093/infdis/jis241
OpenAlex
W2161723369
Cited by
72
References
5
Citations by year
2026: 1 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 8 · 2018: 4 · 2017: 9 · 2016: 7 · 2015: 6 · 2014: 7 · 2013: 7 · 2012: 2
FWCI
4.53
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • World Health Organization
  • Royal Society
Topics
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
  • Social Sciences › Health › Vaccine Coverage and Hesitancy
  • Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
Keywords
oral polio vaccine, intestinal mucosal immunity, waning immunity, acute flaccid paralysis, vaccine take, seasonal variation, enterovirus infection, polio eradication, India
MeSH terms
Child, Preschool, Feces, Female, Humans, India, Infant, Intestinal Mucosa, Male, Poliomyelitis, Poliovirus Vaccine, Oral, Seasons, Time Factors, Vaccination, Logistic Models, Virus Shedding, Poliovirus, Immunity, Mucosal

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