The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Extravaginal reservoirs of vaginal bacteria as risk factors for incident bacterial vaginosis.
Open accessAbstract
BACKGROUND: Bacterial vaginosis (BV) represents shifts in microbiota from Lactobacillus spp. to diverse anaerobes. Although antibiotics relieve symptoms and temporarily eradicate BV-associated bacteria (BVAB), BV usually recurs. We investigated the role of extravaginal BVAB reservoirs in recurrence. METHODS: Risks for BV acquisition over the course of 1 year were defined. DNA in vaginal, anal, and oral swab samples from enrollment was subjected to quantitative polymerase chain reaction assays targeting 16S ribosomal RNA genes of Gardnerella vaginalis, Lactobacillus crispatus, BVAB1, BVAB2, BVAB3, Megasphaera spp., Lactobacillus jensenii, and Leptotrichia/Sneathia spp. A case-control approach analyzed BVAB detection at enrollment for case patients (BV acquisition) versus controls (none). RESULTS: Of 239 women enrolled without BV, 199 were seen in follow-up, and 40 experienced BV; 15 had all samples for analysis. Detection of G. vaginalis in oral cavity or anal samples and Leptotrichia/Sneathia spp. in anal samples was more common at enrollment among case patients, who also had higher concentrations of these bacteria and Megasphaera relative to 30 controls at each site. In contrast, L. crispatus was detected more frequently in anal samples among controls. CONCLUSIONS: Women who acquire BV are more likely have previous colonization of extravaginal reservoirs with some BVAB, and less likely to have L. crispatus, suggesting that BVAB may be acquired vaginally from extravaginal reservoirs.
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“Within a community-based cohort of WSW, extravaginal (i.e., oral and rectal) reservoirs of BV-associated bacteria were a risk factor for incident BV (316).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [316]
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How Does Diet Impact the Vaginal Microbiome?
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Metadata
- Authors
- Marrazzo, J. M., Fiedler, T. L., Srinivasan, S., Thomas, K. K., Liu, C., Ko, D., Xie, H., Saracino, M., & Fredricks, D. N.
- Affiliations
- University of Washington (US)
- Fred Hutch Cancer Center (US)
- Corresponding author
- Marrazzo, Jeanne M.
- ORCID
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-03-23
- Volume
- 205
- Issue
- 10
- Pages
- 1580-1588
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- PMC
- PMC3415820
- OpenAlex
- W2139092047
- Cited by
- 123
- References
- 36
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 10 · 2023: 8 · 2022: 5 · 2021: 14 · 2020: 12 · 2019: 10 · 2018: 6 · 2017: 9 · 2016: 8 · 2015: 3 · 2014: 9 · 2013: 9 · 2012: 6
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (P30CA015704)
- National Institute of Allergy and Infectious Diseases (R01AI052228, R01AI061628, R01 AI 52228-01)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Keywords
- bacterial vaginosis, Gardnerella vaginalis, Megasphaera, Lactobacillus crispatus, Lactobacillus jensenii, vaginal microbiota
- MeSH terms
- Adolescent, Adult, Anal Canal, Bacteria, Disease Reservoirs, DNA, Bacterial, Female, Follow-Up Studies, Gardnerella vaginalis, Humans, Lactobacillus, Mouth, Risk Factors, RNA, Ribosomal, 16S, Cohort Studies, Case-Control Studies, Vaginosis, Bacterial, Leptotrichia, Megasphaera, Metagenome, Young Adult
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