The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Extravaginal reservoirs of vaginal bacteria as risk factors for incident bacterial vaginosis.
Open accessAbstract
BACKGROUND: Bacterial vaginosis (BV) represents shifts in microbiota from Lactobacillus spp. to diverse anaerobes. Although antibiotics relieve symptoms and temporarily eradicate BV-associated bacteria (BVAB), BV usually recurs. We investigated the role of extravaginal BVAB reservoirs in recurrence. METHODS: Risks for BV acquisition over the course of 1 year were defined. DNA in vaginal, anal, and oral swab samples from enrollment was subjected to quantitative polymerase chain reaction assays targeting 16S ribosomal RNA genes of Gardnerella vaginalis, Lactobacillus crispatus, BVAB1, BVAB2, BVAB3, Megasphaera spp., Lactobacillus jensenii, and Leptotrichia/Sneathia spp. A case-control approach analyzed BVAB detection at enrollment for case patients (BV acquisition) versus controls (none). RESULTS: Of 239 women enrolled without BV, 199 were seen in follow-up, and 40 experienced BV; 15 had all samples for analysis. Detection of G. vaginalis in oral cavity or anal samples and Leptotrichia/Sneathia spp. in anal samples was more common at enrollment among case patients, who also had higher concentrations of these bacteria and Megasphaera relative to 30 controls at each site. In contrast, L. crispatus was detected more frequently in anal samples among controls. CONCLUSIONS: Women who acquire BV are more likely have previous colonization of extravaginal reservoirs with some BVAB, and less likely to have L. crispatus, suggesting that BVAB may be acquired vaginally from extravaginal reservoirs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Within a community-based cohort of WSW, extravaginal (i.e., oral and rectal) reservoirs of BV-associated bacteria were a risk factor for incident BV (316).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [316]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774
Nugent, R. P., Krohn, M. A., & Hillier, S. L. (1991) · Journal of Clinical Microbiology · doi:10.1128/jcm.29.2.297-301.1991 · Cited by 3,332
Amsel, R., Totten, P. A., Spiegel, C. A., Chen, K. C. S., Eschenbach, D. A., & Holmes, K. K. (1983) · The American Journal of Medicine · doi:10.1016/0002-9343(83)91112-9 · Cited by 2,412
Defining the healthy “core microbiome” of oral microbial communities
Zaura, E., Keijser, B. J., Huse, S. M., & Crielaard, W. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-259 · Cited by 1,323
Bradshaw, C. S., Morton, A. N., Hocking, J. S., Garland, S. M., Morris, M. B., Moss, L. M., Horvath, L. B., Kuzevska, I., & Fairley, C. K. (2006) · The Journal of Infectious Diseases · doi:10.1086/503780 · Cited by 793
Koumans, E. H., Sternberg, M., Bruce, C., McQuillan, G., Kendrick, J., Sutton, M., & Markowitz, L. E. (2007) · Sexually Transmitted Diseases · doi:10.1097/olq.0b013e318074e565 · Cited by 761
Bacterial vaginosis as a risk factor for preterm delivery: A meta-analysis
Leitich, H., Bodner‐Adler, B., Brunbauer, M., Kaider, A., Egarter, C., & Husslein, P. W. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2003.339 · Cited by 735
Bacterial vaginosis and HIV acquisition: A meta-analysis of published studies
Atashili, J., Poole, C., Ndumbe, P. M., Adimora, A. A., & Smith, J. S. (2008) · AIDS · doi:10.1097/qad.0b013e3283021a37 · Cited by 706
Bacterial diversity within the human subgingival crevice
Kroes, I., Lepp, P. W., & Relman, D. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14547 · Cited by 606
Temporal Variability of Human Vaginal Bacteria and Relationship with Bacterial Vaginosis
Srinivasan, S., Liu, C., Mitchell, C. M., Fiedler, T. L., Thomas, K. K., Agnew, K. J., Marrazzo, J. M., & Fredricks, D. N. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010197 · Cited by 471
Research works printed but not linked: 2
- Hillier, 2008, Bacterial vaginosis, 737
- Srinavasan, 2008, Human vaginal bacterial community dynamics assessed by quantitative PCR and relationship with bacterial vaginosis
Cited by
Sorted by citations
Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 3,018
Sexually Transmitted Diseases Treatment Guidelines, 2010
Workowski, K., & BOLAN, G. A. (2011) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2011.04.006 · Cited by 2,074
The Vaginal Microbiota: What Have We Learned after a Decade of Molecular Characterization?
van de Wijgert, J. H. H. M., Borgdorff, H., Verhelst, R., Crucitti, T., Francis, S. C., Verstraelen, H., & Jespers, V. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105998 · Cited by 480
Interplay between the temporal dynamics of the vaginal microbiota and human papillomavirus detection
Brotman, R. M., Shardell, M. D., Gajer, P., Tracy, J. K., Zenilman, J. M., Ravel, J., & Gravitt, P. E. (2014) · Journal of Infectious Diseases · doi:10.1093/infdis/jiu330 · Cited by 411
Aldunate, M., Srbinovski, D., Hearps, A. C., Latham, C. F., Ramsland, P. A., Gugasyan, R., Cone, R. A., & Tachedjian, G. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00164 · Cited by 395
Metadata
- Authors
- Marrazzo, J. M., Fiedler, T. L., Srinivasan, S., Thomas, K. K., Liu, C., Ko, D., Xie, H., Saracino, M., & Fredricks, D. N.
- Affiliations
- University of Washington (US)
- Fred Hutch Cancer Center (US)
- Corresponding author
- Marrazzo, Jeanne M.
- ORCID
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-03-23
- Volume
- 205
- Issue
- 10
- Pages
- 1580-1588
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- PMC
- PMC3415820
- OpenAlex
- W2139092047
- Cited by
- 123
- References
- 36
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 10 · 2023: 8 · 2022: 5 · 2021: 14 · 2020: 12 · 2019: 10 · 2018: 6 · 2017: 9 · 2016: 8 · 2015: 3 · 2014: 9 · 2013: 9 · 2012: 6
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (P30CA015704)
- National Institute of Allergy and Infectious Diseases (R01AI052228, R01AI061628, R01 AI 52228-01)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Keywords
- bacterial vaginosis, Gardnerella vaginalis, Megasphaera, Lactobacillus crispatus, Lactobacillus jensenii, vaginal microbiota
- MeSH terms
- Adolescent, Adult, Anal Canal, Bacteria, Disease Reservoirs, DNA, Bacterial, Female, Follow-Up Studies, Gardnerella vaginalis, Humans, Lactobacillus, Mouth, Risk Factors, RNA, Ribosomal, 16S, Cohort Studies, Case-Control Studies, Vaginosis, Bacterial, Leptotrichia, Megasphaera, Metagenome, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
