Tuberculosis Diagnostics in 2015: Landscape, Priorities, Needs, and Prospects
Open accessAbstract
In 2015, tuberculosis remains a major global health problem, and drug-resistant tuberculosis is a growing threat. Although tuberculosis diagnosis in many countries is still reliant on older tools, new diagnostics are changing the landscape. Stimulated, in part, by the success and roll out of Xpert MTB/RIF, there is now considerable interest in new technologies. The landscape looks promising, with a robust pipeline of new tools, particularly molecular diagnostics, and well over 50 companies actively engaged in product development. However, new diagnostics are yet to reach scale, and there needs to be greater convergence between diagnostics development and development of shorter-duration tuberculosis drug regimens. Another concern is the relative absence of non-sputum-based diagnostics in the pipeline for children and of biomarker tests for triage, cure, and progression of latent Mycobacterium tuberculosis infection. Several initiatives, described in this supplement, have been launched to further stimulate product development and policy, including assessment of needs and priorities, development of target product profiles, compilation of data on resistance-associated mutations, and assessment of market size and potential for new diagnostics. Advocacy is needed to increase funding for tuberculosis research and development, and governments in high-burden countries must invest more in tuberculosis control to meet post-2015 targets for care, control, and prevention.
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M. tuberculosis is often not detectable in paucibacillary paediatric specimens, and host biomarkers are not yet in place to reliably identify children with TB disease.
“Mycobacterium tuberculosis (M. tuberculosis) is often not detectable in paucibacillary paediatric specimens and host biomarkers are not yet in place to reliably identify children with TB disease [5, 6].”
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“tuberculosis) is often not detectable in paucibacillary paediatric specimens and host biomarkers are not yet in place to reliably identify children with TB disease [5, 6].”
Background
- Authors
- Pai, M., & Schito, M.
- Affiliations
- McGill University (CA)
- Henry M. Jackson Foundation (US)
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-03-10
- Volume
- 211
- Issue
- suppl_2
- Pages
- S21-S28
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- PMC
- PMC4366576
- OpenAlex
- W2102135808
- Cited by
- 193
- References
- 37
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 11 · 2023: 14 · 2022: 11 · 2021: 10 · 2020: 21 · 2019: 22 · 2018: 13 · 2017: 27 · 2016: 28 · 2015: 18
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (HHSN272200800014C)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Keywords
- tuberculosis diagnosis, drug-resistant tuberculosis, Xpert MTB/RIF, molecular diagnosis, pediatric tuberculosis, latent tuberculosis infection, biomarkers, target product profile, resistance-associated mutations, tuberculosis control policy
- MeSH terms
- Diagnostic Tests, Routine, Humans, Tuberculosis, Molecular Diagnostic Techniques, Biomedical Research
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