Tuberculosis
Abstract
Tuberculosis (TB) is an airborne infectious disease caused by organisms of the Mycobacterium tuberculosis complex. Although primarily a pulmonary pathogen, M. tuberculosis can cause disease in almost any part of the body. Infection with M. tuberculosis can evolve from containment in the host, in which the bacteria are isolated within granulomas (latent TB infection), to a contagious state, in which the patient will show symptoms that can include cough, fever, night sweats and weight loss. Only active pulmonary TB is contagious. In many low-income and middle-income countries, TB continues to be a major cause of morbidity and mortality, and drug-resistant TB is a major concern in many settings. Although several new TB diagnostics have been developed, including rapid molecular tests, there is a need for simpler point-of-care tests. Treatment usually requires a prolonged course of multiple antimicrobials, stimulating efforts to develop shorter drug regimens. Although the Bacillus Calmette-Guérin (BCG) vaccine is used worldwide, mainly to prevent life-threatening TB in infants and young children, it has been ineffective in controlling the global TB epidemic. Thus, efforts are underway to develop newer vaccines with improved efficacy. New tools as well as improved programme implementation and financing are necessary to end the global TB epidemic by 2035.
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TB is caused by the inhalation of droplet nuclei containing M. tuberculosis that enter the respiratory tract and infect the alveoli of the lungs.
“TB is caused by the inhalation of droplet nuclei containing M. tuberculosis that enter the respiratory tract and infect the alveoli of the lungs.”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [149]
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Self-citation
- Authors
- Pai, M., Behr, M. A., Dowdy, D., Dheda, K., Divangahi, M., Boehme, C. C., Ginsberg, A., Swaminathan, S., Spigelman, M., Getahun, H., Menzies, D., & Raviglione, M.
- Affiliations
- Manipal Academy of Higher Education (IN)
- McGill University (CA)
- Johns Hopkins University (US)
- University of Cape Town (ZA)
- FIND (CH)
- Aeras (US)
- Indian Council of Medical Research (IN)
- TB Alliance (US)
- World Health Organization (CH)
- Corresponding author
- Pai, Madhukar
- ORCID
- Venue
- Nature Reviews Disease Primers
- Published
- 2016-10-27
- Volume
- 2
- Issue
- 1
- Pages
- 16076-16076
- ISSN
- 2056-676X (ISSN-L)
- OpenAlex
- W4210627381
- Cited by
- 1,270
- References
- 189
- Citations by year
- 2026: 136 · 2025: 158 · 2024: 159 · 2023: 152 · 2022: 150 · 2021: 151 · 2020: 104 · 2019: 99 · 2018: 106 · 2017: 53
- FWCI
- 13.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Reviews Disease Primers (publishedVersion)
- PubMed (publishedVersion)
- Funders
- United States Agency for International Development
- Bill and Melinda Gates Foundation
- World Health Organization
- Public Health Agency of Canada
- European Commission
- Australian Agency for International Development
- National Research Foundation
- South African Medical Research Council
- Indian Council of Medical Research
- Public Health Agency
- Department for International Development
- Ministerie van Buitenlandse Zaken
- Global Health Innovative Technology Fund
- National Institutes of Health
- Centers for Disease Control and Prevention
- U.S. Food and Drug Administration
- Canadian Institutes of Health Research (143273_1)
- Medical Research Council
- National Institute of Allergy and Infectious Diseases
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Health Sciences › Medicine › Surgery › Diagnosis and treatment of tuberculosis
- Keywords
- tuberculosis, Mycobacterium tuberculosis complex, latent tuberculosis infection, active pulmonary tuberculosis, drug-resistant tuberculosis, TB diagnostics, point-of-care testing, TB treatment regimens, BCG vaccine, tuberculosis vaccine
- MeSH terms
- Antitubercular Agents, BCG Vaccine, Humans, Mycobacterium tuberculosis, Tuberculosis
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