The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Antibody to Influenza Virus Neuraminidase: An Independent Correlate of Protection
Abstract
BACKGROUND: Laboratory correlates of influenza vaccine protection can best be identified by examining people who are infected despite vaccination. While the importance of antibody to viral hemagglutinin (HA) has long been recognized, the level of protection contributed independently by antibody to viral neuraminidase (NA) has not been determined. METHODS: Sera from a controlled trial of the efficacies of inactivated influenza vaccine (IIV) and live attenuated influenza vaccine (LAIV) were tested by hemagglutination inhibition (HAI) assay, microneutralization (MN) assay, and a newly standardized lectin-based neuraminidase inhibition (NAI) assay. RESULTS: The NAI assay detected a vaccine response in 37% of IIV recipients, compared with 77% and 67% of participants in whom responses were detected by the HAI and MN assays, respectively. For LAIV recipients, the NAI, HAI, and MN assays detected responses in 6%, 21%, and 17%, respectively. In IIV recipients, as NAI assay titers rose, the frequency of infection fell, similar to patterns seen with HAI and MN assays. HAI and MN assay titers were highly correlated, but NAI assay titers exhibited less of a correlation. Analyses suggested an independent role for NAI antibody in protection, which was similar in the IIV, LAIV, and placebo groups. CONCLUSIONS: While NAI antibody is not produced to a large extent in response to current IIV, it appears to have an independent role in protection. As new influenza vaccines are developed, NA content should be considered. CLINICAL TRIALS REGISTRATION: NCT00538512.
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Hobson, D., Curry, R. L., Beare, A. S., & Ward-Gardner, A. (1972) · Epidemiology and Infection · doi:10.1017/s0022172400022610 · Cited by 1,002
Rowe, T., Abernathy, R. A., Hu-Primmer, J., Thompson, W. W., Lu, X., Lim, W., Fukuda, K., Cox, N. J., & Katz, J. M. (1999) · Journal of Clinical Microbiology · doi:10.1128/jcm.37.4.937-943.1999 · Cited by 811
Self-citationDETERMINANTS OF IMMUNITY TO INFLUENZA INFECTION IN MAN
POTTER, C. W., & OXFORD, J. S. (1979) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a071545 · Cited by 452
Influenza Hemagglutination-Inhibition Antibody Titer as a Correlate of Vaccine-Induced Protection
Ohmit, S. E., Petrie, J. G., Cross, R. T., Johnson, E., & Monto, A. S. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir661 · Cited by 296
Self-citationCouch, R. B., Atmar, R. L., Franco, L. M., Quarles, J. M., Wells, J., Arden, N., Niño, D., & Belmont, J. W. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis935 · Cited by 280
Comparative Efficacy of Inactivated and Live Attenuated Influenza Vaccines
Monto, A. S., Ohmit, S. E., Petrie, J. G., Johnson, E., Truscon, R., Teich, E., Rotthoff, J., Boulton, M., & Victor, J. C. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808652 · Cited by 277
Self-citationSerologic assays for influenza surveillance, diagnosis and vaccine evaluation
Katz, J. M., Hancock, K., & Xu, X. (2011) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.11.51 · Cited by 235
Self-citationCouzens, L., Gao, J., Westgeest, K., Sandbulte, M., Lugovtsev, V., Fouchier, R., & Eichelberger, M. (2014) · Journal of Virological Methods · doi:10.1016/j.jviromet.2014.09.003 · Cited by 187
Immunological assessment of influenza vaccines and immune correlates of protection
Reber, A., & Katz, J. M. (2013) · Expert Review of Vaccines · doi:10.1586/erv.13.35 · Cited by 160
Self-citationReproducibility of Serologic Assays for Influenza Virus A (H5N1)
Stephenson, I., Heath, A., Major, D., Newman, R. W., Höschler, K., Wang, J., Katz, J. M., Weir, J. P., Zambon, M. C. F. A., & Wood, J. (2009) · Emerging infectious diseases · doi:10.3201/eid1508.081754 · Cited by 145
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Khoury, D. S., Cromer, D., Reynaldi, A., Schlub, T. E., Wheatley, A. K., Juno, J. A., Subbarao, K., Kent, S. J., Triccas, J. A., & Davenport, M. P. (2021) · Nature Medicine · doi:10.1038/s41591-021-01377-8 · Cited by 3,742
Updates on immunologic correlates of vaccine-induced protection
Plotkin, S. A. (2020) · Vaccine · doi:10.1016/j.vaccine.2019.10.046 · Cited by 165
What level of neutralising antibody protects from COVID-19?
Khoury, D. S., Cromer, D., Reynaldi, A., Schlub, T. E., Wheatley, A. K., Juno, J. A., Subbarao, K., Kent, S. J., Triccas, J. A., & Davenport, M. P. (2021) · doi:10.1101/2021.03.09.21252641 · Cited by 3,742
Metadata
- Authors
- Monto, A. S., Petrie, J. G., Cross, R. T., Johnson, E., Liu, M., Zhong, W., Levine, M., Katz, J. M., & Ohmit, S. E.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-04-08
- Volume
- 212
- Issue
- 8
- Pages
- 1191-1199
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2164759517
- Cited by
- 369
- References
- 13
- FWCI
- 16.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Monto, A. S., Petrie, J. G., Cross, R. T., Johnson, E., Liu, M., Zhong, W., Levine, M., Katz, J. M., & Ohmit, S. E. (2015). Antibody to Influenza Virus Neuraminidase: An Independent Correlate of Protection. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiv195
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