Updates on immunologic correlates of vaccine-induced protection

Plotkin, Stanley A.

doi:10.1016/j.vaccine.2019.10.046

Cited by 165Immune responses and vaccinationsSARS-CoV-2 and COVID-19 ResearchImmunotherapy and Immune Responses

Updates on immunologic correlates of vaccine-induced protection

Plotkin, Stanley A.·2020·Vaccine

DOI 10.1016/j.vaccine.2019.10.046

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Abstract

Correlates of protection (CoPs) are increasingly important in the development and licensure of vaccines. Although the study of CoPs was initially directed at identifying a single immune function that could explain vaccine efficacy, it has become increasingly clear that there are often multiple functions responsible for efficacy. This review is meant to supplement prior articles on the subject, illustrating both simple and complex CoPs.

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Finding an immune response that correlates with protection can accelerate the development of and access to new vaccines.
“Finding an immune response that correlates with protection can accelerate the development of and access to new vaccines10”
From A guide to vaccinology: from basic principles to new developments (2021) · cites this paper as [10]

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Authors: Plotkin, S. A.
Affiliations: University of Pennsylvania (US)
Corresponding author: Plotkin, Stanley A.
ORCID: Plotkin, Stanley A.
Venue: Vaccine
Publisher: Elsevier BV
Published: 2020-02
Volume: 38
Issue: 9
Pages: 2250-2257
ISSN: 0264-410X (ISSN-L)
DOI: 10.1016/j.vaccine.2019.10.046
OpenAlex: W2990745657
Cited by: 165
References: 132
Citations by year: 2026: 20 · 2025: 17 · 2024: 21 · 2023: 26 · 2022: 30 · 2021: 33 · 2020: 18
FWCI: 8.08
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Vaccine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: correlates of protection, vaccine-induced immunity, vaccine efficacy, immunogenicity, vaccine licensure, immune function
MeSH terms: Communicable Disease Control, Communicable Diseases, Humans, Vaccines

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