The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Clinical and Laboratory Diagnosis of Dengue Virus Infection
Open accessAbstract
Infection with any of the 4 dengue virus serotypes results in a diverse range of symptoms, from mild undifferentiated fever to life-threatening hemorrhagic fever and shock. Given that dengue virus infection elicits such a broad range of clinical symptoms, early and accurate laboratory diagnosis is essential for appropriate patient management. Virus detection and serological conversion have been the main targets of diagnostic assessment for many years, however cross-reactivity of antibody responses among the flaviviruses has been a confounding issue in providing a differential diagnosis. Furthermore, there is no single, definitive diagnostic biomarker that is present across the entire period of patient presentation, particularly in those experiencing a secondary dengue infection. Nevertheless, the development and commercialization of point-of-care combination tests capable of detecting markers of infection present during different stages of infection (viral nonstructural protein 1 and immunoglobulin M) has greatly simplified laboratory-based dengue diagnosis. Despite these advances, significant challenges remain in the clinical management of dengue-infected patients, especially in the absence of reliable biomarkers that provide an effective prognostic indicator of severe disease progression. This review briefly summarizes some of the complexities and issues surrounding clinical dengue diagnosis and the laboratory diagnostic options currently available.
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Cites
The global distribution and burden of dengue
Bhatt, S., Gething, P. W., Brady, O. J., Messina, J. P., Farlow, A. W., Moyes, C. L., Drake, J. M., Brownstein, J. S., Hoen, A. G., Sankoh, O., et al. (2013) · Nature · doi:10.1038/nature12060 · Cited by 10,037 · cited 2×
“Infection with any of the 4 DENV serotypes can result in a range of clinical outcomes, with the majority of infections (70%–80%) being asymptomatic [10].”
The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus
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Dengue: a continuing global threat
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Dengue and dengue haemorrhagic fever
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Self-citationAlcon, S., Talarmin, A., Debruyne, M., Falconar, A., Deubel, V., & Flamand, M. (2002) · Journal of Clinical Microbiology · doi:10.1128/jcm.40.02.376-381.2002 · Cited by 686
Early Clinical and Laboratory Indicators of Acute Dengue Illness
Kalayanarooj, S., Vaughn, D. W., Nimmannitya, S., Green, S., Suntayakorn, S., Kunentrasai, N., Viramitrachai, W., Ratanachu‐eke, S., Kiatpolpoj, S., Innis, B. L., et al. (1997) · The Journal of Infectious Diseases · doi:10.1086/514047 · Cited by 652
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Self-citation
Cited by
Persistent Joint Pain Following Arthropod Virus Infections
Suchowiecki, K., Reid, S. P., Simon, G. L., Firestein, G. S., & Chang, A. (2021) · Current Rheumatology Reports · doi:10.1007/s11926-021-00987-y · Cited by 37
Metadata
- Authors
- Muller, D. A., Depelsenaire, A. C. I., & Young, P. R.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-03-01
- Volume
- 215
- Issue
- suppl_2
- Pages
- S89-S95
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2606996549
- Cited by
- 438
- References
- 29
- FWCI
- 24.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Muller, D. A., Depelsenaire, A. C. I., & Young, P. R. (2017). Clinical and Laboratory Diagnosis of Dengue Virus Infection. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiw649
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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