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Early Clinical and Laboratory Indicators of Acute Dengue Illness
Abstract
A prospective observational study was conducted to identify early indicators of acute dengue virus infection. Children with fever for <72 h without obvious cause were studied at hospitals in Bangkok and Kamphaeng Phet, Thailand, until resolution of fever. Of 172 evaluable subjects (91% of enrollees), 60 (35%) had dengue, including 32 with dengue fever (DF) and 28 with dengue hemorrhagic fever (DHF). At enrollment, children with dengue were more likely than children with other febrile illnesses (OFI) to report anorexia, nausea, and vomiting and to have a positive tourniquet test, and they had lower total white blood cell counts, absolute neutrophil and absolute monocyte counts, and higher plasma alanine and aspartate (AST) aminotransferase levels than children with OFI. Plasma AST levels were higher in children who developed DHF than in those with DF. These data identify simple clinical and laboratory parameters that help to identify children with DF or DHF.
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Citations
Cited by
Dengue and dengue haemorrhagic fever
Rigau-Pérez, J. G., Clark, G. G., Gubler, D. J., Reiter, P., Sanders, E. J., & Vance Vorndam, A. (1998) · The Lancet · doi:10.1016/s0140-6736(97)12483-7 · Cited by 1,051
Libraty, D. H., Endy, T. P., Houng, H. H., Green, S., Kalayanarooj, S., Suntayakorn, S., Chansiriwongs, W., Vaughn, D. W., Nisalak, A., Ennis, F. A., et al. (2002) · The Journal of Infectious Diseases · doi:10.1086/340365 · Cited by 494
Self-citationGreen, S., Vaughn, D. W., Kalayanarooj, S., Nimmannitya, S., Suntayakorn, S., Nisalak, A., Lew, R., Innis, B. L., Kurane, I., Rothman, A. L., et al. (1999) · The Journal of Infectious Diseases · doi:10.1086/314680 · Cited by 371
Self-citationWhitehorn, J., & Simmons, C. P. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.07.022 · Cited by 282
Immune-mediated cytokine storm and its role in severe dengue
Srikiatkhachorn, A., Mathew, A., & Rothman, A. L. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0625-1 · Cited by 267
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Metadata
- Authors
- Kalayanarooj, S., Vaughn, D. W., Nimmannitya, S., Green, S., Suntayakorn, S., Kunentrasai, N., Viramitrachai, W., Ratanachu‐eke, S., Kiatpolpoj, S., Innis, B. L., Rothman, A. L., Nisalak, A., & Ennis, F. A.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-08
- Volume
- 176
- Issue
- 2
- Pages
- 313-321
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2144628854
- Cited by
- 652
- References
- 0
- FWCI
- 14.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Early Clinical and Laboratory Indicators of Acute Dengue Illness. https://app.cochat.ai/papers/10.1086/514047
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- Kalayanarooj, S., Vaughn, D. W., Nimmannitya, S., Green, S., Suntayakorn, S., Kunentrasai, N., Viramitrachai, W., Ratanachu‐eke, S., Kiatpolpoj, S., Innis, B. L., Rothman, A. L., Nisalak, A., & Ennis, F. A. (1997). Early Clinical and Laboratory Indicators of Acute Dengue Illness. The Journal of Infectious Diseases. https://doi.org/10.1086/514047
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