The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Immune Responses to a Recombinant Glycoprotein E Herpes Zoster Vaccine in Adults Aged 50 Years or Older
Open accessAbstract
Background: The herpes zoster subunit vaccine (HZ/su), consisting of varicella-zoster virus glycoprotein E (gE) and AS01B Adjuvant System, was highly efficacious in preventing herpes zoster in the ZOE-50 and ZOE-70 trials. We present immunogenicity results from those trials. Methods: Participants (ZOE-50: ≥50; ZOE-70: ≥70 years of age) received 2 doses of HZ/su or placebo, 2 months apart. Serum anti-gE antibodies and CD4 T cells expressing ≥2 of 4 activation markers assessed (CD42+) after stimulation with gE-peptides were measured in subcohorts for humoral (n = 3293) and cell-mediated (n = 466) immunogenicity. Results: After vaccination, 97.8% of HZ/su and 2.0% of placebo recipients showed a humoral response. Geometric mean anti-gE antibody concentrations increased 39.1-fold and 8.3-fold over baseline in HZ/su recipients at 1 and 36 months post-dose 2, respectively. A gE-specific CD42+ T-cell response was shown in 93.3% of HZ/su and 0% of placebo recipients. Median CD42+ T-cell frequencies increased 24.6-fold (1 month) and 7.9-fold (36 months) over baseline in HZ/su recipients and remained ≥5.6-fold above baseline in all age groups at 36 months. The proportion of CD4 T cells expressing all 4 activation markers increased over time in all age groups. Conclusions: Most HZ/su recipients developed robust immune responses persisting for 3 years following vaccination. Clinical Trials Registration: NCT01165177; NCT01165229.
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A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults
Oxman, M. N., Levin, M. J., Johnson, G. R., Schmader, K. E., Straus, S. E., Gelb, L. D., Arbeit, R. D., Simberkoff, M. S., Gershon, A. A., Davis, L. E., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051016 · Cited by 2,412
Self-citationEfficacy of the Herpes Zoster Subunit Vaccine in Adults 70 Years of Age or Older
Cunningham, A. L., Lal, H., Kovac, M., Chlibek, R., Hwang, S.-J., Díez-Domingo, J., Godeaux, O., Levin, M. J., McElhaney, J. E., Puig-Barberà, J., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1603800 · Cited by 1,070
Self-citationDidierlaurent, A. M., Collignon, C., Bourguignon, P., Wouters, S., Fierens, K., Fochesato, M., Dendouga, N., Langlet, C., Malissen, B., Lambrecht, B. N., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400948 · Cited by 266
Leroux-Roels, I., Leroux-Roels, G., Clement, F., Vandepapelière, P., Vassilev, V., Ledent, E., & Heineman, T. C. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis497 · Cited by 147
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Crooke, S. N., Ovsyannikova, I. G., Poland, G. A., & Kennedy, R. B. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0164-9 · Cited by 530
Updates on immunologic correlates of vaccine-induced protection
Plotkin, S. A. (2020) · Vaccine · doi:10.1016/j.vaccine.2019.10.046 · Cited by 165
Monslow, M. A., Elbashir, S., Sullivan, N. L., Thiriot, D. S., Ahl, P., Smith, J., Miller, E., Cook, J., Cosmi, S., Thoryk, E., et al. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.06.062 · Cited by 75
Maréchal, C., Lal, H., Poder, A., Ferguson, M., Enweonye, I., Heineman, T. C., Hervé, C., Rheault, P., Talli, J., Wauters, D., et al. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.05.110 · Cited by 36
Self-citationPicard, E., Bowdish, D. M. E., McElhaney, J. E., Pawelec, G., Loeb, M., & Verschoor, C. P. (2021) · Clinical and Experimental Immunology · doi:10.1111/cei.13593 · Cited by 3
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Metadata
- Authors
- Cunningham, A. L., Heineman, T. C., Lal, H., Godeaux, O., Chlibek, R., Hwang, S.-J., McElhaney, J. E., Vesikari, T., Andrews, C., Choi, W. S., Esen, M., Ikematsu, H., Choma, M. K., Pauksens, K., Ravault, S., Salaun, B., Schwarz, T. F., Smetana, J., Abeele, C. V., Van den Steen, P., Vastiau, I., Weckx, L. Y., Levin, M. J., & ZOE-50/70 Study Group
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-02-26
- Volume
- 217
- Issue
- 11
- Pages
- 1750-1760
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2789400684
- Cited by
- 204
- References
- 4
- FWCI
- 14.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
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