Obesity increases the duration of influenza a virus shedding in adults
Open accessAbstract
Epidemiologic studies indicate that obesity increases the risk of severe complications and death from influenza virus infections, especially in elderly individuals. This work investigates the effect of obesity on the duration of viral shedding within household transmission studies in Managua, Nicaragua, over 3 seasons (2015-2017). Symptomatic obese adults were shown to shed influenza A virus 42% longer than nonobese adults (adjusted event time ratio [ETR], 1.42; 95% confidence interval [CI], 1.06-1.89); no association was observed with influenza B virus shedding duration. Even among paucisymptomatic and asymptomatic adults, obesity increased the influenza A shedding duration by 104% (adjusted ETR, 2.04; 95% CI, 1.35-3.09). These findings suggest that obesity may play an important role in influenza transmission.
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Obesity is linked with longer influenza A virus shedding and more severe forms of COVID-19 infections.
“Obesity has also been linked with longer influenza A virus shedding (Maier et al., 2018) and more severe forms of COVID-19 infections (Stefan et al., 2020).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Maier et al., 2018
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- Authors
- Maier, H. E., Lopez, R., Sanchez, N., Ng, S., Gresh, L., Ojeda, S., Burger-Calderon, R., Kuan, G., Harris, E., Balmaseda, A., & Gordon, A.
- Affiliations
- University of Michigan (US)
- Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua, Nicaragua
- Sustainable Sciences Institute, Managua, Nicaragua
- Sustainable Sciences Institute (US)
- Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley
- Ministerio de Salud (NI)
- University of California, Berkeley (US)
- Corresponding author
- Gordon, Aubree
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-08-02
- Volume
- 218
- Issue
- 9
- Pages
- 1378-1382
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- PMC
- PMC6151083
- OpenAlex
- W2885406006
- Cited by
- 245
- References
- 16
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 12 · 2023: 20 · 2022: 45 · 2021: 60 · 2020: 75 · 2019: 13 · 2018: 2
- FWCI
- 29.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Infectious Diseases (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01 AI120997, HHSN272201400006C)
- Fogarty International Center (K02TW009483)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Keywords
- obesity, influenza A virus, viral shedding duration, household transmission, influenza B, asymptomatic viral shedding, adults, Managua, Nicaragua
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Influenza, Human, Male, Middle Aged, Nicaragua, Obesity, Influenza A virus, Virus Shedding, Young Adult
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