The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Aging and developmental transitions in the B cell lineage
Abstract
One explanation for the deterioration of the humoral immune response in elderly individuals is that B lymphopoiesis declines with increasing age. Recent studies report a dramatic decline in pre-B cell numbers in old mice. Surprisingly, the number of mature B cells does not decline with age. To determine if new B cells are made in aged animals despite the drop in pre-B cells, we used 5'-bromo-2-deoxyuridine labeling to determine the production rate of B cells in the bone marrow and spleen of young and old mice. Because of the great variability in the number of early B lineage cells in old mice, we acquired data on >60 young and 50 old mice throughout these experiments. The transitional and mature B cell compartments in the spleen have slower labeling kinetics in old mice as compared to young. By the end of 4 weeks of labeling, an average of only 15% of the mature B cell compartment consists of newly made cells compared to 30% in young mice. However, in contrast to an earlier report, our results indicate that there is no statistical difference in the rate of production of new immature B cells in the marrow of young and old animals. In total, our results confirm previous work showing that mature B cells in old mice have a slower turnover, but more importantly suggest that the defect in mature B cell turnover is not due to a decline in B lymphopoiesis, but rather an inability of the newly made cells to replenish the peripheral compartments.
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“In mice, the turnover of mature spleen B cells also decreases with age [143, 144].”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [143]
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Cites
Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.
Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D., & Hayakawa, K. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.5.1213 · Cited by 1,604
The aging immune system: primer and prospectus
Miller, R. A. (1996) · Science · doi:10.1126/science.273.5271.70 · Cited by 1,165
An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway
Schiemann, B. J., Gommerman, J. L., Vora, K. A., Cachero, T. G., Shulga‐Morskaya, S., Dobles, M., Frew, E. M., & Scott, M. L. (2001) · Science · doi:10.1126/science.1061964 · Cited by 1,070
Turnover of naive- and memory-phenotype T cells.
Tough, D. F., & Sprent, J. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.4.1127 · Cited by 869
Hartley, S. B., Cooke, M. P., Fulcher, D. A., Harris, A. W., Cory, S., Basten, A., & Goodnow, C. C. (1993) · Cell · doi:10.1016/0092-8674(93)90111-3 · Cited by 509
Most peripheral B cells in mice are ligand selected.
Gu, H., Tarlinton, D. M., Müller, W., Rajewsky, K., & Förster, I. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.6.1357 · Cited by 414
Allman, D., Ferguson, S. E., Lentz, V. M., & Cancro, M. P. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.9.4431 · Cited by 408
Transitional B cells are the target of negative selection in the B cell compartment.
Carsetti, R., Köhler, G., & Lamers, M. C. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.6.2129 · Cited by 358
High prevalence of anti-cardiolipin and other autoantibodies in a healthy elderly population.
Manoussakis, M. N., Tzioufas, A. G., Silis, M. P., Pange, P. J. E., Goudevenos, J. A., & Moutsopoulos, H. Μ. (1987) · PubMed Central · Cited by 339
Molecular and cellular origins of B lymphocyte diversity
Rolink, A. G., & Melchers, F. (1991) · Cell · doi:10.1016/0092-8674(91)90032-t · Cited by 330
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Nauman, G., Danzl, N. M., Lee, J., Borsotti, C., Madley, R., Fu, J., Hölzl, M. A., Dahmani, A., Dorronsoro, A., Chavez, É., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100966 · Cited by 5
Khatami, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-66475-0_3 · Cited by 6
Enhancing T Lineage Production in Aged Mice: A Novel Function of Foxn1 in the Bone Marrow Niche
Zook, E. C., Zhang, S., Gerstein, R. M., Witte, P. L., & Le, P. T. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202278 · Cited by 4
Loss of early B cell protein λ5 decreases bone mass and accelerates skeletal aging
Khass, M., Rashid, H., Burrows, P. D., Javed, A., & Schroeder, H. W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.906649 · Cited by 4
Khomtchouk, K. M., Alter, S., Ratliff, M., Blomberg, B. B., & Riley, R. L. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.11.004 · Cited by 4
Bone Loss and TLR4 Signals Contribute Independently to B Lineage Aging
Baker, E., Montecino‐Rodriguez, E., Xu, S., Tetradis, S., Rouault, A., Estrada, O. I., & Dorshkind, K. A. (2025) · Aging Cell · doi:10.1111/acel.70267 · Cited by 3
Hematological Malignancies in the Elderly: The Epidemiological Perspective
Quaglia, A., Vercelli, M., Lillini, R., & AIRTUM Working Group (2014) · Springer eBooks · doi:10.1007/978-1-4471-2837-3_1 · Cited by 3
Nikolaou, C., Mühle, K., Schlickeiser, S., Japp, A. S., Matzmohr, N., Kunkel, D., Frentsch, M., & Thiel, A. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00235-y · Cited by 3
Characteristics of B Cells and B Cell Responses in Aged Individuals
Mei, H. E., & Radbruch, A. (2011) · Springer eBooks · doi:10.1007/978-3-0346-0219-8_4 · Cited by 2
B-Cell Repertoire Changes in Mouse Models of Aging
Scholz, J. L., Quinn, W. J., & Cancro, M. P. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_20 · Cited by 1
Fallah, M. P. (2011) · UKnowledge (University of Kentucky)
Promoting Thymopoiesis with Age: Potential Role of the Transcription Factor Foxn1
Zook, E. C. (2012) · Loyola eCommons (Loyola University of Chicago)
Alternations in the Splenic Marginal Zone with Age
Birjandi, S. Z. (2011) · Loyola eCommons (Loyola University of Chicago)
Ziegler, N. (2010) · Loyola eCommons (Loyola University of Chicago)
New Cells in Old Mice: The ABCs of Humoral Immunosenescence
Hao, Y. (2012) · Open Longevity Science · doi:10.2174/1876326x01206010112
Nicknam, M. H., & Rezaiemanesh, A. (2013) · Springer eBooks · doi:10.1007/978-3-642-39495-9_14
Anti-Aging Medicine LiteratureWatch
(2003) · Rejuvenation Research · doi:10.1089/109454503765361588
B Cell Repertoire Changes in Mouse Models of Aging
Scholz, J. L., Hao, Y., Quinn, W. J., & Cancro, M. P. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_20-1
B Cell Repertoire Changes in Mouse Models of Aging
Scholz, J. L., Hao, Y., Quinn, W. J., & Cancro, M. P. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_20
Park, C. Y. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735174745.793568351
Effect of Ageing on The Immune System, A Review
Alsudairy, N. M., Saeedi, S. S. I., Alfarhan, N. A., HAMID, A. H. M. A., Alqawain, A. H. A., AlDawood, Z. A. A., Aljumah, D. J., Althobaiti, H. S., Sadeq, A. G., Alnemari, F. M. A., et al. (2022) · Saudi Medical Horizons Journal · doi:10.54293/smhj.v2i2.43
AGING, A PATHOLOGICAL FACTOR IN NEUROLOGICAL INJURY
Vijikumar, A. (2022) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.11613
Nikolaou, C., Mühle, K., Schlickeiser, S., Japp, A. S., Matzmohr, N., Kunkel, D., Frentsch, M., & Thiel, A. (2021) · Figshare · doi:10.6084/m9.figshare.14456667
Constitutive and regulated marrow adipocytes do not actively inhibit B lymphopoiesis.
Montecino-Rodriguez, E., Baker, E., & Dorshkind, K. (2026) · Journal of Immunology · doi:10.1093/jimmun/vkag006
Bejarano-García, J. A., Nufer, M., Caracuel-García, R., Caballero‐Velázquez, T., Gil, A. R., Jimenes, A. J., Muñoz, R., Piruat, J. I., & Pérez‐Simón, J. A. (2026) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2026.09.011
Metadata
- Authors
- Johnson, K. M.
- Affiliations
- Loyola University Medical Center (US)
- Corresponding author
- Johnson, K. M.
- Venue
- International Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-11-01
- Volume
- 14
- Issue
- 11
- Pages
- 1313-1323
- ISSN
- 0953-8178 (ISSN-L)
- 1460-2377
- OpenAlex
- W2137896220
- Cited by
- 128
- References
- 35
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 10 · 2012: 6
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (K07AG000997, R01AG13874, K07 AG00997, R01AG013874)
- National Institute of Allergy and Infectious Diseases (T32AI007508, T32 AI 07508)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Keywords
- B cell aging, B cell development, pre-B cells, mature B cells, bone marrow, spleen, 5-bromo-2'-deoxyuridine labeling, developmental transitions, aged mice
- MeSH terms
- Aging, Animals, B-Lymphocytes, Bone Marrow, Bromodeoxyuridine, Cell Differentiation, Female, Flow Cytometry, Kinetics, Mice, Inbred BALB C, Spleen, Staining and Labeling, Cellular Senescence, Mice
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