Cited by 1,165T-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

The aging immune system: primer and prospectus

Miller, Richard A.·1996·Science

Abstract

Changes in T lymphocyte populations underlie much of the age-related decline in the protective immune response. Aging leads to the replacement of virgin T cells by memory T cells and to the accumulation of cells with signal transduction defects. Studies of antibody gene assembly, accessory cell function, post-thymic T cell development, skewed selection of T cell receptor repertoire, and the clinical concomitants of immune senescence will shed new light on the causes and consequences of age-dependent immune failure.

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Crossref · 10.1126/science.273.5271.70

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  • Immune ageing involves fewer stem cells, changed T-cell production, weaker B-cell antibody responses, and less phagocytosis by neutrophils, macrophages and natural killer cells.

    “The ageing immune system is characterised by a decline in stem cells, alterations in T-lymphocyte production, blunting of the B-cell led antibody response and reduced phagocytic activity of neutrophils, macrophages and natural killer cells (50, 51).”

    From Frailty in elderly people (2013) · cites this paper as [51]

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Authors
Miller, R. A.
Affiliations
University of Michigan (US)
Corresponding author
Miller, Richard A.
Venue
Science
Published
1996-07-05
Volume
273
Issue
5271
Pages
70-74
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2043464691
Cited by
1,165
References
71
Citations by year
2026: 7 · 2025: 7 · 2024: 15 · 2023: 19 · 2022: 9 · 2021: 22 · 2020: 34 · 2019: 25 · 2018: 33 · 2017: 32 · 2016: 24 · 2015: 31 · 2014: 26 · 2013: 40 · 2012: 35
FWCI
5.20
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Keywords
immunosenescence, aging, T cells, memory T cells, T cell receptor repertoire, signal transduction defects, accessory cell function, age-related immune decline
MeSH terms
Aged, Aged, 80 and over, Aging, Animals, Antibody Formation, Antigen-Presenting Cells, B-Lymphocytes, Cytotoxicity, Immunologic, Disease Susceptibility, Humans, Immune System, Immunologic Memory, Killer Cells, Natural, Longevity, Receptors, Antigen, T-Cell, T-Lymphocytes

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