Cited by 128T-cell and B-cell ImmunologyHematopoietic Stem Cell TransplantationLymphoma Diagnosis and Treatment

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Aging and developmental transitions in the B cell lineage

Johnson, K. M.·2002·International Immunology

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Abstract

One explanation for the deterioration of the humoral immune response in elderly individuals is that B lymphopoiesis declines with increasing age. Recent studies report a dramatic decline in pre-B cell numbers in old mice. Surprisingly, the number of mature B cells does not decline with age. To determine if new B cells are made in aged animals despite the drop in pre-B cells, we used 5'-bromo-2-deoxyuridine labeling to determine the production rate of B cells in the bone marrow and spleen of young and old mice. Because of the great variability in the number of early B lineage cells in old mice, we acquired data on >60 young and 50 old mice throughout these experiments. The transitional and mature B cell compartments in the spleen have slower labeling kinetics in old mice as compared to young. By the end of 4 weeks of labeling, an average of only 15% of the mature B cell compartment consists of newly made cells compared to 30% in young mice. However, in contrast to an earlier report, our results indicate that there is no statistical difference in the rate of production of new immature B cells in the marrow of young and old animals. In total, our results confirm previous work showing that mature B cells in old mice have a slower turnover, but more importantly suggest that the defect in mature B cell turnover is not due to a decline in B lymphopoiesis, but rather an inability of the newly made cells to replenish the peripheral compartments.

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Authors: Johnson, K. M.
Affiliations: Loyola University Medical Center (US)
Corresponding author: Johnson, K. M.
Venue: International Immunology
Publisher: Oxford University Press (OUP)
Published: 2002-11-01
Volume: 14
Issue: 11
Pages: 1313-1323
ISSN: 0953-8178 (ISSN-L)
1460-2377
DOI: 10.1093/intimm/dxf092
OpenAlex: W2137896220
Cited by: 128
References: 35
Citations by year: 2026: 2 · 2025: 3 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 10 · 2012: 6
FWCI: 2.84
Type: journal article
Language: en
Open access: closed
Locations: International Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (K07AG000997, R01AG13874, K07 AG00997, R01AG013874)
National Institute of Allergy and Infectious Diseases (T32AI007508, T32 AI 07508)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
Keywords: B cell aging, B cell development, pre-B cells, mature B cells, bone marrow, spleen, 5-bromo-2'-deoxyuridine labeling, developmental transitions, aged mice
MeSH terms: Aging, Animals, B-Lymphocytes, Bone Marrow, Bromodeoxyuridine, Cell Differentiation, Female, Flow Cytometry, Kinetics, Mice, Inbred BALB C, Spleen, Staining and Labeling, Cellular Senescence, Mice

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Aging and developmental transitions in the B cell lineage

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