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Cited by 115T-cell and B-cell ImmunologyHematopoietic Stem Cell TransplantationMyasthenia Gravis and Thymoma

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

The aged thymus shows normal recruitment of lymphohematopoietic progenitors but has defects in thymic epithelial cells

Gui, J., Zhu, X., Dohkan, J., Cheng, L., Barnes, P. F., Su, D.-M.·2007·International Immunology
DOI 10.1093/intimm/dxm095
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Abstract

Aging is associated with reduced numbers of all thymocyte sub-populations, including early T-cell progenitors. However, it is unclear if this is due to inadequate recruitment of lymphohematopoietic progenitor cells (LPCs) to the aged thymus or to abnormal development of T cells within the thymus. We found that LPCs from young mice were recruited equally well to the thymi of young or aged mice and that thymic stromal cells (TSCs) from young and old mice expressed similar levels of P-selectin and CCL25, which are believed to mediate recruitment of LPCs to the adult thymus. However, the number of recruited thymocytes in old thymus was markedly reduced after two weeks, indicating that T-cell development or proliferation is defective in the aged thymus. We also found that LPCs from aged and young mice have similar capacities to seed a fetal thymus that was transplanted under the kidney capsule. Thymic epithelial cells (TECs) in aged mice had lower proliferative capacity and higher rate of apoptosis, compared with findings in young animals. In addition, immunofluorescence staining with antibodies to cortical and medullary TECs revealed that aged thymi had a disorganized thymic stromal architecture, combined with reduced cellularity of the medulla, and apoptosis of thymocyte sub-populations in the medullary microenvironment was increased, compared with that in young mice. We conclude that aging does not impair recruitment of LPCs to the thymus, but is characterized by abnormalities in thymic epithelial architecture, especially medullary TEC function that may provide sub-optimal support for thymic development of LPCs.

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Crossref · 10.1093/intimm/dxm095

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  1. Shortman, 1990, Seminars in immunology, 2, 3

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Metadata

Authors
Gui, J., Zhu, X., Dohkan, J., Cheng, L., Barnes, P. F., & Su, D.-M.
Affiliations
  • The University of Texas Health Science Center at Tyler (US)
  • Sheng Jing Hospital (CN)
  • National Center for Geriatrics and Gerontology (JP)
ORCID
Venue
International Immunology
Publisher
Oxford University Press (OUP)
Published
2007-09-05
Volume
19
Issue
10
Pages
1201-1211
ISSN
  • 0953-8178 (ISSN-L)
  • 1460-2377
DOI
10.1093/intimm/dxm095
OpenAlex
W2132561227
Cited by
115
References
37
Citations by year
2026: 4 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 7 · 2020: 9 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 7 · 2015: 6 · 2014: 3 · 2013: 7 · 2012: 6
FWCI
2.98
Type
journal article
Language
en
Open access
closed
Locations
  • International Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (R21AG031880)
  • National Institute of Allergy and Infectious Diseases (R21AI064939)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Clinical Neurology › Myasthenia Gravis and Thymoma
Keywords
thymus aging, thymic epithelial cells, T cell development, thymic stromal cells, P-selectin, CCL25, thymic medulla, apoptosis, thymocyte proliferation, thymus transplantation
MeSH terms
Aging, Animals, Epithelial Cells, Fetus, Hematopoietic Stem Cells, Mice, Inbred C57BL, Thymus Gland, Apoptosis, P-Selectin, Chemokines, CC, Cell Proliferation, Mice, Lymphoid Progenitor Cells

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