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IL-1 and TNF -initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes irreversible joint damage and significant disability. However, the fundamental mechanisms underlying how inflammation and joint destruction in RA develop and are sustained chronically remain largely unknown. Here, we show that signal transducer and activator of transcription 3 (STAT3) is the key mediator of both chronic inflammation and joint destruction in RA. We found that inflammatory cytokines highly expressed in RA patients, such as IL-1β, tumor necrosis factor alpha and IL-6, activated STAT3 either directly or indirectly and in turn induced expression of IL-6 family cytokines, further activating STAT3 in murine osteoblastic and fibroblastic cells. STAT3 activation also induced expression of receptor activator of nuclear factor kappa B ligand (RANKL), a cytokine essential for osteoclastogenesis, and STAT3 deficiency or pharmacological inhibition promoted significant reduction in expression of both IL-6 family cytokines and RANKL in vitro. STAT3 inhibition was also effective in treating an RA model, collagen-induced arthritis, in vivo through significant reduction in expression of IL-6 family cytokines and RANKL, inhibiting both inflammation and joint destruction. Leukemia inhibitory factor expression and STAT3 activation by IL-1β were mainly promoted by IL-6 but still induced in IL-6-deficient cells. Thus, our data provide new insight into RA pathogenesis and provide evidence that inflammatory cytokines trigger a cytokine amplification loop via IL-6-STAT3 that promotes sustained inflammation and joint destruction.
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“These cytokines in turn stimulate the expression of RANKL in osteoblasts,73 enhancing the osteoclastogenesis previously activated by the release of ATP by apoptotic osteocytes.66”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [73]
Citations
Cites
Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,224
Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
Self-citationScott, D. L., Wolfe, F., & Huizinga, T. W. J. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60826-4 · Cited by 3,263
Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087
Elliott, M. J., Maini, R. N., Feldmann, M., Kalden, J. R., Antoni, C., Smolen, J. S., Leeb, B., Breedveld, F. C., Macfarlane, J. D., Bijl, J. A., et al. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90628-9 · Cited by 1,682
Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.
Keffer, J., Probert, L., Cazlaris, H. E., Georgopoulos, S., Kaslaris, E., Kioussis, D., & Kollias, G. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04978.x · Cited by 1,670
Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
Murphy, C. A., Langrish, C. L., Chen, Y., Blumenschein, W., McClanahan, T., Kastelein, R. A., Sedgwick, J. D., & Cua, D. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030896 · Cited by 1,669
Autoimmunity to type II collagen an experimental model of arthritis.
Trentham, D. E., Townes, A. S., & Kang, A. H. (1977) · The Journal of Experimental Medicine · doi:10.1084/jem.146.3.857 · Cited by 1,608
STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells
Yang, X. O., Panopoulos, A. D., Nurieva, R., Chang, S. H., Wang, D., Watowich, S. S., & Dong, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c600321200 · Cited by 1,530
Cited by
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Items 101–200 of 328
DeVaux, R. S., Ropri, A. S., Grimm, S. L., Hall, P. A., Herrera, E. O., Chittur, S. V., Smith, W. P., Coarfa, C., Behbod, F., & Herschkowitz, J. I. (2020) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29621 · Cited by 39
Lee, H., Jang, E., Kang, S., Shin, J., Han, H.-S., Kim, T., Lee, D. H., Lee, J. H., Jang, D. S., & Lee, K. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106726 · Cited by 39
Metformin coordinates osteoblast/osteoclast differentiation associated with ischemic osteonecrosis
Park, S., Kang, M., Moon, Y. J., Jang, K. Y., & Kim, J. R. (2020) · Aging · doi:10.18632/aging.102796 · Cited by 38
Russell, T., Bridgewood, C., Rowe, H., Altaie, A., Jones, E., & McGonagle, D. (2021) · Seminars in Immunopathology · doi:10.1007/s00281-021-00836-1 · Cited by 39
Chaudhary, R., Prasad, A., Agarwal, V., Rehman, M., Kumar, A., Kaushik, A. S., Srivastava, S., Srivastava, S., & Mishra, V. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111046 · Cited by 40
Potočnjak, I., Marinić, J., Batičić, L., Šimić, L., Broznić, D., & Domitrović, R. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111472 · Cited by 37
Mediators of Inflammation-Induced Bone Damage in Arthritis and Their Control by Herbal Products
Nanjundaiah, S. M., Astry, B., & Moudgil, K. D. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/518094 · Cited by 40
Woo, S. J., Lim, K., Park, S., Jung, M. Y., Lim, H. S., Jeon, M.-G., Lee, S.-I., & Park, B. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.01.011 · Cited by 36
Montani, M. S. G., Santarelli, R., Falcinelli, L., Gonnella, R., Granato, M., Renzo, L. D., Cuomo, L., Vitillo, M., Faggioni, A., & Cirone, M. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.2a0118-029rr · Cited by 36
Metabolic pathways mediate pathogenesis and offer targets for treatment in rheumatic diseases
Wyman, B., & Perl, A. (2019) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000687 · Cited by 35
Glaucoma after Ocular Surgery or Trauma
Chen, X., Lei, F., Zhou, C., Chodosh, J., Wang, L., Huang, Y., Dohlman, C. H., & Paschalis, E. I. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.07.006 · Cited by 36
Osteocyte RANKL Drives Bone Resorption in Mouse Ligature-Induced Periodontitis
Kittaka, M., Yoshimoto, T., Levitan, M. E., Urata, R., Choi, R. B., Teno, Y., Xie, Y., Kitase, Y., Prideaux, M., Dallas, S. L., et al. (2023) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4897 · Cited by 37
Bone resorption: supporting immunometabolism
van Niekerk, G., Mitchell, M., & Engelbrecht, A. (2018) · Biology Letters · doi:10.1098/rsbl.2017.0783 · Cited by 37
Li, Y., Zhu, Z., Zhang, T., & Zhou, Y. (2018) · Archives of Pharmacal Research · doi:10.1007/s12272-018-1089-0 · Cited by 35
Magni, L., Bouazzi, R., Olmedilla, H. H., Petersen, P. S. S., Tozzi, M., & Novak, I. (2021) · Cells · doi:10.3390/cells10081928 · Cited by 35
Epigenetic Reactivation of RANK in Glioblastoma Cells by Curcumin: Involvement of STAT3 Inhibition
Wu, B., Yao, X.-Q., Nie, X., & Xu, R. (2013) · DNA and Cell Biology · doi:10.1089/dna.2013.2042 · Cited by 35
Exposure to ambient air pollution and osteoarthritis; an animal study
Fitriyah, A., Nikolenko, D. A., Abdelbasset, W. K., Maashi, M. S., Jalil, A. T., Yasin, G., Abdulkadhm, M. M., Самиева, Г. У., Lafta, H. A., Abed, A. M., et al. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.134698 · Cited by 34
Li, R., Cai, L., Ren, D.-Y., Xie, X., Hu, C., & Li, J. (2012) · International Immunopharmacology · doi:10.1016/j.intimp.2012.07.001 · Cited by 34
Non-receptor tyrosine kinase signaling in autoimmunity and therapeutic implications
Solouki, S., August, A., & Huang, W. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.05.008 · Cited by 37
Zhang, Y., Guo, H., Cheng, B. C., Su, T., Fu, X., Li, T., Zhu, P., Tse, A. K., Pan, S.-Y., & Yu, Z. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s160645 · Cited by 31
Hi-JAKi-ng Synovial Fibroblasts in Inflammatory Arthritis With JAK Inhibitors
Burja, B., Mertelj, T., & Frank‐Bertoncelj, M. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00124 · Cited by 33
Roeleveld, D. M., van Nieuwenhuijze, A. E. M., van den Berg, W. B., & Koenders, M. I. (2013) · BioDrugs · doi:10.1007/s40259-013-0035-4 · Cited by 32
Regulation of energy balance by leptin as an adiposity signal and modulator of the reward system
Asgari, R., Caceres-Valdiviezo, M., Wu, S., Hamel, L., Humber, B. E., Agarwal, S. M., Fletcher, P. J., Fulton, S., Hahn, M., & Pereira, S. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102078 · Cited by 35
Yusuf, A., & Casey, A. (2019) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.104641 · Cited by 30
Ju, A., Cho, Y.-C., & Cho, S. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.07.038 · Cited by 31
Particulate matter exposure aggravates osteoarthritis severity
Peng, K., Liu, J., Chiang, Y., Chen, P., Chiang, M., Shih, H., Chang, P., & Lee, C. (2019) · Clinical Science · doi:10.1042/cs20190458 · Cited by 29
Yu, K., Ma, Y., Li, X., Wu, X., Liu, W., Li, X., Shen, J., & Wang, H. (2016) · Cell Biology International · doi:10.1002/cbin.10696 · Cited by 29
Wang, S., Lin, H.-Y., Chen, Y., Hsu, T., Chuang, J., Kao, T., & Ko, C. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1535-z · Cited by 29
Park, Y. J., Kim, D., Jeong, M. H., Yu, J. S., So, H. M., Bang, I. J., Kim, H. R., Kwon, S., Kim, K. H., & Chung, K. H. (2019) · Cells · doi:10.3390/cells9010030 · Cited by 29
Hao, Z., Ma, Y., Wu, J., Li, X., Chen, H., Shen, J., & Wang, H. (2017) · RSC Advances · doi:10.1039/c7ra09308j · Cited by 28
Ghallab, D. S., Shawky, E. M., Ghareeb, D. A., Abdulmalek, S. A., El-Din, S. M. M., Mohyeldin, M. M., & Ibrahim, R. S. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.102091 · Cited by 28
Glant, T. T., Besenyei, T., Kádár, A., Kurkó, J., Tryniszewska, B., Gál, J., Soós, G., Szekanecz, Z., Hoffmann, G., Block, J. A., et al. (2013) · Arthritis & Rheumatism · doi:10.1002/art.37986 · Cited by 27
Gkouveris, I., Nikitakis, N. G., & Sauk, J. J. (2015) · Journal of Cancer Therapy · doi:10.4236/jct.2015.68078 · Cited by 27
Wang, C., Song, Y., Wang, X., Mao, R., & Song, L. (2018) · Medical Science Monitor · doi:10.12659/msm.910347 · Cited by 27
Culibrk, R. A., & Hahn, M. S. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.583884 · Cited by 28
Bao, C., Chen, H., Mou, X.-J., Zhu, X.-K., Zhao, Q., & Wang, X. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.023 · Cited by 26
RetractedDynamic microstructural changes in alveolar bone in ligature‐induced experimental periodontitis
Wu, Y., Taya, Y., Kuraji, R., Ito, H., Soeno, Y., & Numabe, Y. (2019) · Odontology · doi:10.1007/s10266-019-00471-1 · Cited by 26
Yin, X., Yang, Z., Zhu, M., Chen, C., Huang, S., Li, X., Zhong, H., Wen, H., Sun, Q., Yu, X., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.890624 · Cited by 26
Ibrahim, S. S. A., Salama, M. A., Selima, E., & Shehata, R. R. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118261 · Cited by 25
Liu, X., Chen, J. G., Munshi, M. N., Hunter, Z. R., Xu, L., Kofides, A., Tsakmaklis, N., Demos, M. G., Guerrera, M. L., Chan, G., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2019000947 · Cited by 25
Pharmacological properties and derivatives of saikosaponins—a review of recent studies
Zhu, Y., & Lai, Y. (2023) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgad052 · Cited by 24
Rovani, M. T., Ilha, G. F., Gasperin, B. G., da Nóbrega, J. E., Siddappa, D., Glanzner, W. G., Antoniazzi, A. Q., Bordignon, V., Duggavathi, R., & Gonçalves, P. B. D. (2017) · Molecular Reproduction and Development · doi:10.1002/mrd.22798 · Cited by 24
Impact of Exposure to Ambient Fine Particulate Matter Pollution on Adults with Knee Osteoarthritis
Chen, H., Wu, J., Wang, M., Wang, S., Wang, J., Yu, H., Hu, Y., & Shang, S. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18189644 · Cited by 24
Ganguly, K., Luthfikasari, R., Randhawa, A., Dutta, S. D., Patil, T. V., Acharya, R., & Lim, K. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400581 · Cited by 23
WHI-131 Promotes Osteoblast Differentiation and Prevents Osteoclast Formation and Resorption in Mice
Cheon, Y., Kim, J., Baek, J. M., Ahn, S., Jun, H. Y., Erkhembaatar, M., Kim, M. S., Lee, M. S., & Oh, J. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2612 · Cited by 23
Zeng, S., Zhang, T., Chen, Y., Chu-Tan, J., Jin, K., Lee, S.-R., Yam, M. X., Madigan, M. C., Fernando, N., Cioanca, A., et al. (2022) · Theranostics · doi:10.7150/thno.71038 · Cited by 22
IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse
Oike, T., Kanagawa, H., Sato, Y., Kobayashi, T., Nakatsukasa, H., Miyamoto, K., Nakamura, S., Kaneko, Y., Kobayashi, S., Harato, K., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-34173-5 · Cited by 22
Self-citationJannus, F., Medina‐O’Donnell, M., Neubrand, V. E., Marín, M., Sáez‐Lara, M. J., Sepúlveda, M. R., Rufino‐Palomares, E. E., Martı́nez, A., Lupiáñez, J. A., Parra, A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158158 · Cited by 22
Immunomodulatory Drugs in the Treatment of Hidradenitis Suppurativa—Possibilities and Limitations
Świerczewska, Z., Lewandowski, M., Surowiecka, A., & Barańska‐Rybak, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179716 · Cited by 22
Role of Suppressors of Cytokine Signaling 3 in Bone Inflammatory Responses
Gao, A., & Dyke, T. E. V. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00506 · Cited by 22
Cysteine Cathepsins: Potential Applications in Diagnostics and Therapy of Malignant Tumors
Petushkova, A. I., Savvateeva, L. V., Korolev, D. O., & Zamyatnin, A. A. (2019) · Biochemistry (Moscow) · doi:10.1134/s000629791907006x · Cited by 22
Modulation of IL-6 receptor/STAT3 downstream signaling in rheumatoid arthritis patients
Cacciapaglia, F., Perniola, S., Stano, S., Venerito, V., Natuzzi, D., Bizzoca, R., & Iannone, F. (2024) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2024.104951 · Cited by 21
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Yang, H., Liu, J., & Yang, K. (2019) · Photobiomodulation Photomedicine and Laser Surgery · doi:10.1089/photob.2018.4615 · Cited by 21
Chen, Y., Wu, J., Leung, W.-C., Liu, Y., Fu, X., Zhu, J., Wu, Y., Chou, J., Yin, C., Wang, Y., et al. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153254 · Cited by 21
Kim, B. E., Hui-Beckman, J. W., Lyubchenko, T. A., Hall, C. F., Fallahi, S., Brull, A., Goleva, E., & Leung, D. Y. M. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.01.027 · Cited by 22
Sheng, N., Wang, J., Xing, F., Duan, X., & Xiang, Z. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.139472 · Cited by 21
Wang, L., Zhao, Q., Wang, N., Ding, Y., Kong, L., & Wang, J. (2021) · Journal of Biological Research - Thessaloniki · doi:10.1186/s40709-020-00131-4 · Cited by 21
Pulsed Electromagnetic Field (PEMF) Treatment Ameliorates Murine Model of Collagen-Induced Arthritis
Hong, J.-E., Lee, C.-G., Hwang, S., Kim, J., Jo, M., Kang, D.-H., Yoo, S.-H., Kim, W.-S., Lee, Y., & Rhee, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021137 · Cited by 21
Mycobacterium tuberculosis promotes arthritis development through toll-like receptor 2
Kanagawa, H., Niki, Y., Kobayashi, T., Sato, Y., Katsuyama, E., Fujie, A., Hao, W., Miyamoto, K., Tando, T., Watanabe, R., et al. (2014) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-014-0575-9 · Cited by 21
Self-citationFerreira-Fernandes, H., Barros, M. A. L., Filho, M. D. S., Medeiros, J. V. R., Vasconcelos, D. F. P., da Silva, D. A., Leódido, A. C. M., Silva, F. R. P., França, L. F. D. C., Lenardo, D. D., et al. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.02.002 · Cited by 20
Shen, W., Guan, Y., Wu, R., Liu, L., Li, H.-D., Bao, W., Zhang, Y., Nandakumar, K. S., Ye, G., & Shen, X. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.111861 · Cited by 22
Chronotherapy targeting cytokine secretion attenuates collagen-induced arthritis in mice
Yaekura, A., Yoshida, K., Morii, K., Oketani, Y., Okumura, I., Kaneshiro, K., Shibanuma, N., Sakai, Y., & Hashiramoto, A. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106549 · Cited by 20
Corbet, M., Pineda, M. A., Yang, K., Tarafdar, A., McGrath, S., Nakagawa, R., Lumb, F. E., Suckling, C. J., Harnett, W., & Harnett, M. M. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1010069 · Cited by 22
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Thota, S., Begum, R., Kaur, G., Bagam, P., Dorsey, W. C., & Batra, S. (2022) · Toxicology in Vitro · doi:10.1016/j.tiv.2022.105378 · Cited by 18
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Zhang, R., Peng, S., & Zhu, G. (2022) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2022.07.001 · Cited by 19
Ren, D., Xu, T., Li, R., Huang, C., Huang, Y., Li, R. Q., Li, H. Y., & Li, J. (2013) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x13500420 · Cited by 18
Sultana, S., Adhikary, R., Nandi, A., & Bishayi, B. (2016) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.08.021 · Cited by 18
The Role of “Bone Immunological Niche” for a New Pathogenetic Paradigm of Osteoporosis
Pagliari, D., Tamburrelli, F. C., Zirio, G., Newton, E. E., & Cianci, R. (2015) · Analytical Cellular Pathology · doi:10.1155/2015/434389 · Cited by 20
Shi, L., Yuan, Z., Liu, J., Cai, R., Hasnat, M., Yu, H., Feng, J., Wang, Z., Zhao, Q., Wu, M. H., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113825 · Cited by 17
Colon Fibroblasts and Inflammation: Sparring Partners in Colorectal Cancer Initiation?
Onfroy-Roy, L., Hamel, D., Malaquin, L., & Ferrand, A. (2021) · Cancers · doi:10.3390/cancers13081749 · Cited by 20
Osteoimmunology of Spondyloarthritis
Fassio, A., Atzeni, F., Rossini, M., D’Amico, V., Cantatore, F. P., Chimenti, M. S., Crotti, C., Frediani, B., Giusti, A., Peluso, G., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914924 · Cited by 18
Gao, J., Zheng, W., WANG, L., & Song, B. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3302 · Cited by 17
RetractedPašková, Ľ., Kuncírová, V., Poništ, S., Mihalová, D., Nosáľ, R., Harmatha, J., Hrádková, I., Čavojský, T., Bilka, F., Šišková, K., et al. (2016) · Journal of Immunology Research · doi:10.1155/2016/7509653 · Cited by 17
Differential inflammatory landscape stimulus during titanium surfaces obtained osteogenic phenotype
Feltran, G. D. S., Bezerra, F., Fernandes, C. J. D. C., Ferreira, M. R., & Zambuzzi, W. F. (2019) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36673 · Cited by 17
Sultana, S., & Bishayi, B. (2019) · Immunobiology · doi:10.1016/j.imbio.2019.11.022 · Cited by 17
Han, T. T. Y., Walker, J. T., Grant, A. L., Dekaban, G. A., & Flynn, L. E. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.642465 · Cited by 17
Neuroinflammation and pathways that contribute to tourette syndrome
Wu, X., Hao, J., Jiang, K., Wu, M., Zhao, X., & ZHANG, X. Y. (2025) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-025-01874-3 · Cited by 16
Kanagaraj, P., Chen, J. Y., Skaggs, K., Qadeer, Y., Connors, M., Cutler, N. S., Richmond, J., Kommidi, V., Poles, A., Affrunti, D., et al. (2023) · Glia · doi:10.1002/glia.24444 · Cited by 26
Steinman, J. R., & DeBoer, M. D. (2013) · Vitamins and hormones · doi:10.1016/b978-0-12-410473-0.00008-8 · Cited by 16
The Role of the Transcriptional Regulation of Stromal Cells in Chronic Inflammation
Valín, Á., & Pablos, J. L. (2015) · Biomolecules · doi:10.3390/biom5042723 · Cited by 17
Qiu, M., Mo, L., Li, J., Liang, H., Zhu, W., Zheng, X., Duan, X., & Xu, W. (2019) · Clinical Rheumatology · doi:10.1007/s10067-019-04894-7 · Cited by 16
Wen, H., Luo, J., Li, X., Wei, D.-D., & Liu, Y. (2018) · Immunologic Research · doi:10.1007/s12026-018-9033-4 · Cited by 15
Delcuve, G. P., Lakowski, T. M., Su, R., Beacon, T. H., & Davie, J. (2020) · IUBMB Life · doi:10.1002/iub.2380 · Cited by 15
Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways
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Okragly, A. J., Hamang, M., Pena, E. A., Baker, H. E., Bullock, H. A., Lucchesi, J., Martin, A. P., Ma, Y. L., & Benschop, R. J. (2016) · Cytokine · doi:10.1016/j.cyto.2015.12.011 · Cited by 16
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Lin, J., Cai, R., Sun, B., Dong, J., Zhao, Y., Miao, Q., & Chen, C. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb01097h · Cited by 15
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Lagha, A. B., Maquera-Huacho, P. M., & Grenier, D. (2021) · PLoS ONE · doi:10.1371/journal.pone.0252029 · Cited by 15
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Self-citationLi, J., Zheng, Z., Du, M., Chen, J., Zhu, H., Hu, Z., Zhu, Y., & Wang, J. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.713840 · Cited by 13
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Liu, X., Zhang, X., Gao, Y., Tian, J., & Zhao, J. (2023) · eFood · doi:10.1002/efd2.119 · Cited by 13
Metadata
- Authors
- Mori, T., Miyamoto, T., Yoshida, H., Asakawa, M., Kawasumi, M., Kobayashi, T., Morioka, H., Chiba, K., Toyama, Y., & Yoshimura, A.
- Affiliations
- Keio University (JP)
- Venue
- International Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-09-21
- Volume
- 23
- Issue
- 11
- Pages
- 701-712
- ISSN
- 0953-8178 (ISSN-L)
- 1460-2377
- OpenAlex
- W2127938598
- Cited by
- 328
- References
- 49
- Citations by year
- 2026: 24 · 2025: 24 · 2024: 16 · 2023: 25 · 2022: 27 · 2021: 33 · 2020: 33 · 2019: 33 · 2018: 28 · 2017: 22 · 2016: 13 · 2015: 15 · 2014: 10 · 2013: 15 · 2012: 9
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (21689040, 23590573)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Keywords
- rheumatoid arthritis, STAT3 signaling, IL-1β, TNF-α, interleukin-6, IL-6 family cytokines, RANKL, osteoclastogenesis, joint destruction, collagen-induced arthritis, leukemia inhibitory factor, osteoblasts, fibroblasts, chronic inflammation
- MeSH terms
- Animals, Arthritis, Experimental, Arthritis, Rheumatoid, Chronic Disease, Enzyme Inhibitors, Fibroblasts, Humans, Inflammation, Joints, Mice, Inbred C57BL, Mice, Inbred DBA, Osteoclasts, Piperidines, Pyrimidines, Pyrroles, Tumor Necrosis Factor-alpha, Signal Transduction, Interleukin-6, Gene Expression, STAT3 Transcription Factor, Mice, RANK Ligand, Interleukin-1beta
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