Bacterial resistance to antibiotics as a function of outer membrane permeability
Abstract
The outer membrane of Gram-negative bacteria serves as barrier to permeation. Transport across this barrier often occurs through channels created by porins. Changes in these porins can account for antibiotic resistance. The combination of a permeability barrier and beta-lactamases in the periplasmic space leads to a situation in which concentrations, at the target, of even third-generation cephalosporins, can be significantly decreased.
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The crisis in antibiotic resistance
Neu, H. C. (1992) · Science · doi:10.1126/science.257.5073.1064 · Cited by 2,834 · see citing works
Lekshmi, M., Ammini, P., Kumar, S., & Varela, M. F. (2017) · Microorganisms · doi:10.3390/microorganisms5010011 · Cited by 194 · see citing works
- Authors
- Nikaido, H.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Nikaido, Hiroshi
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 1988-07
- Volume
- 22
- Issue
- Supplement_A
- Pages
- 17-22
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2292725038
- Cited by
- 49
- References
- 0
- Citations by year
- 2024: 1 · 2023: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Antimicrobial Chemotherapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- antibiotic resistance, outer membrane permeability, porin, Gram-negative bacteria, beta-lactamase, third-generation cephalosporins, periplasm
- MeSH terms
- Anti-Bacterial Agents, Cell Membrane, Cell Membrane Permeability, Drug Resistance, Microbial, Gram-Negative Bacteria
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