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Photodynamic antimicrobial chemotherapy (PACT)
Abstract
Whereas the photodynamic therapy (PDT) of cancer has recently shown rapid clinical acceptance, photodynamic antimicrobial chemotherapy (PACT)--which predates the related cancer regimen--is not widely appreciated. Like PDT, PACT utilizes photosensitizers and visible or ultraviolet light in order to give a phototoxic response, normally via oxidative damage. Currently, the major use of PACT is in the disinfection of blood products, particularly for viral inactivation, although more clinically-based protocols are being developed, e.g. in the treatment of oral infection. The technique has been shown to be effective in vitro against bacteria (including drug-resistant strains), yeasts, viruses and parasites. A wide range of photosensitizers, both natural and synthetic, is available with differing physicochemical make-up and light-absorption properties. PACT is proposed as a potential, low-cost approach to the treatment of locally occurring infection.
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Cited by
Antimicrobial photodynamic therapy – what we know and what we don’t
Cieplik, F., Deng, D., Crielaard, W., Buchalla, W., Hellwig, E., Al-Ahmad, A., & Maisch, T. (2018) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2018.1467876 · Cited by 902
Photodynamic Therapy in Dentistry
Konopka, K., & Goslinski, T. (2007) · Journal of Dental Research · doi:10.1177/154405910708600803 · Cited by 854
Symposium‐in‐Print: Singlet Oxygen Invited Review
Redmond, R. W., & Kochevar, I. E. (2006) · Photochemistry and Photobiology · doi:10.1562/2006-04-14-ir-874 · Cited by 421
Antimicrobial properties of porphyrins
Stojiljkovic, I., Evavold, B. D., & Kumar, V. (2001) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.10.2.309 · Cited by 209
Applications of Antimicrobial Photodynamic Therapy against Bacterial Biofilms
Songca, S. P., & Adjei, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063209 · Cited by 175
Metadata
- Authors
- Wainwright, M.
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-07-01
- Volume
- 42
- Issue
- 1
- Pages
- 13-28
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2019098068
- Cited by
- 1,233
- References
- 0
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wainwright, M. (1998). Photodynamic antimicrobial chemotherapy (PACT). Journal of Antimicrobial Chemotherapy. https://doi.org/10.1093/jac/42.1.13
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
