The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Mechanisms of quinolone action and microbial response
Abstract
Over the years, chromosomal mapping of the bacterial genome of Escherichia coli has demonstrated that many loci are associated with quinolone resistance, which is mainly a result of chromosomal mutation or alteration of the quantity or type of porins in the outer membrane of Gram-negative bacteria. There has been one report of a small and confined episode of plasmid-mediated resistance to fluoroquinolones, which did not appear to persist. With the increasingly widespread use of an expanding range of fluoroquinolone antibiotics, a range and mix in individual bacterial isolates of the different mechanisms of resistance to fluoroquinolones will undoubtedly be encountered amongst clinically significant bacteria. Currently, transferable resistance is extremely rare and most resistant bacteria arise from clonal expansion of mutated strains. However, it is conceivable that in the future, horizontal gene transfer may become a more important means of conferring resistance to fluoroquinolones.
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Cites
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Cited by
An overview of the antimicrobial resistance mechanisms of bacteria
C Reygaert, W., & Department of Biomedical Sciences, O. U. W. B. S. O. M. (2018) · AIMS Microbiology · doi:10.3934/microbiol.2018.3.482 · Cited by 1,893
Pham, T. D. M., Ziora, Z. M., & Blaskovich, M. A. T. (2019) · MedChemComm · doi:10.1039/c9md00120d · Cited by 785
Bacterial Topoisomerase Inhibitors: Quinolone and Pyridone Antibacterial Agents
Mitscher, L. A. (2005) · Chemical Reviews · doi:10.1021/cr030101q · Cited by 781
Mechanisms of antibiotic resistance in enterococci
Miller, W. R., Munita, J. M., & Arias, C. A. (2014) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2014.956092 · Cited by 772
Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae
Nordmann, P., & Poirel, L. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki245 · Cited by 425
Metadata
- Authors
- Hawkey, P. M.
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-05-01
- Volume
- 51
- Issue
- 90001
- Pages
- 29-35
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2109363737
- Cited by
- 288
- References
- 30
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- closed
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