The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae
Abstract
Although quinolone resistance results mostly from chromosomal mutations in Enterobacteriaceae, it may also be mediated by plasmid-encoded Qnr determinants. Qnr proteins protect DNA from quinolone binding and compromise the efficacy of quinolones such as nalidixic acid. Qnr proteins (QnrA-like, QnrB and QnrS) have been identified worldwide with a quite high prevalence among Asian isolates with a frequent association with clavulanic acid inhibited expanded-spectrum beta-lactamases and plasmid-mediated cephalosporinases. The qnrA genes are embedded in complex sul1-type integrons. A very recent identification of the origin of QnrA determinants in the water-borne species Shewanella algae underlines the role of the environment as a reservoir for this emerging threat. It may help to determine the location of in vivo transfer of qnrA genes. Further analysis of the role (if any) of quinolones for enhancing this gene transfer may be conducted. This could prevent the spread, if still possible, of this novel antibiotic resistance mechanism.
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Cites
National Committee for Clinical Laboratory Standards
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DNA gyrase, topoisomerase IV, and the 4-quinolones.
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Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa
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Quinolone resistance from a transferable plasmid
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Emerging Mechanisms of Fluoroquinolone Resistance
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Mechanism of plasmid-mediated quinolone resistance
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Cited by
Origins and evolution of antibiotic resistance
Davies, J., & Davies, D. (2010) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00016-10 · Cited by 5,784
Cabello, F. C. (2006) · Environmental Microbiology · doi:10.1111/j.1462-2920.2006.01054.x · Cited by 2,329
Wellington, E. M., Boxall, A. B., Cross, P., Feil, E. J., Gaze, W. H., Hawkey, P. M., Johnson-Rollings, A. S., Jones, D. L., Lee, N. M., Otten, W., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(12)70317-1 · Cited by 1,122
Prevalence in the United States of aac(6 ′ ) - Ib - cr Encoding a Ciprofloxacin-Modifying Enzyme
Park, C. H., Robicsek, A., Jacoby, G. A., Sahm, D., & Hooper, D. C. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00915-06 · Cited by 757
IS CR Elements: Novel Gene-Capturing Systems of the 21st Century?
Toleman, M. A., Bennett, P. M., & Walsh, T. R. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00048-05 · Cited by 587
Metadata
- Authors
- Nordmann, P., & Poirel, L.
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-07-14
- Volume
- 56
- Issue
- 3
- Pages
- 463-469
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2100494916
- Cited by
- 425
- References
- 38
- FWCI
- 16.26
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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