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Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection
Abstract
Quinolones are broad-spectrum antibacterial agents, commonly used in both clinical and veterinary medicine. Their extensive use has resulted in bacteria rapidly developing resistance to these agents. Two mechanisms of quinolone resistance have been established to date: alterations in the targets of quinolones, and decreased accumulation due to impermeability of the membrane and/or an overexpression of efflux pump systems. Recently, mobile elements have also been described, carrying the qnr gene, which confers resistance to quinolones.
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Cited by
Evolutionary paths to antibiotic resistance under dynamically sustained drug selection
Toprak, E., Veres, A., Michel, J.-B., Chait, R., Hartl, D. L., & Kishony, R. (2012) · Nature Genetics · doi:10.1038/ng.1034 · Cited by 764
Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment
Shaikh, S., Fatima, J., Shakil, S., Rizvi, S. M. D., & Kamal, M. A. (2015) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2014.08.002 · Cited by 758
Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae
Nordmann, P., & Poirel, L. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki245 · Cited by 425
The emergence of antibiotic resistance by mutation
Woodford, N., & Ellington, M. J. (2007) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2006.01492.x · Cited by 417
Evolutionary History of the Global Emergence of the Escherichia coli Epidemic Clone ST131
Stoesser, N., Sheppard, A. E., Pankhurst, L., De Maio, N., Moore, C. E., Sebra, R., Turner, P., Anson, L. W., Kasarskis, A., Batty, E. M., et al. (2016) · mBio · doi:10.1128/mbio.02162-15 · Cited by 334
Metadata
- Authors
- Ruiz, J.
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-04-14
- Volume
- 51
- Issue
- 5
- Pages
- 1109-1117
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2126326498
- Cited by
- 711
- References
- 0
- FWCI
- 8.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ruiz, J. (2003). Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection. Journal of Antimicrobial Chemotherapy. https://doi.org/10.1093/jac/dkg222
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
