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Cited by 166Sepsis Diagnosis and TreatmentAntibiotics Pharmacokinetics and EfficacyLipoproteins and Cardiovascular Health

Statins for infection and sepsis: a systematic review of the clinical evidence.

Falagas, M. E., Makris, G. C., Matthaiou, D. K., Rafailidis, P. I.·2008·Journal of Antimicrobial Chemotherapy
DOI 10.1093/jac/dkn019
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Abstract

INTRODUCTION: Statins are currently used for hyperlipidaemia control and considered useful for protection from cardiovascular events. In addition, there is increasing evidence for the potential use of statins in preventing and treating infections. METHODS: We performed a systematic review of the literature that compared the outcome between statin and non-statin users among patients suffering from sepsis or other infections. The relevant studies were identified from searches of PubMed, Scopus and the Cochrane Library databases. RESULTS: Twenty studies were identified (13 of them were retrospective), out of which 9 examined the use of statins in patients with sepsis, bacteraemia or multiorgan dysfunction syndrome, 4 community-acquired pneumonia (CAP), 1 ICU infections, 2 other bacterial infections and 4 viral infections. Eleven studies had data regarding mortality as the main outcome: 8 showed decreased mortality in statin users (3 of them reported on patients with bacteraemia), 2 showed no difference in mortality and 1 reported an increased mortality in patients who received statins. Seven studies examined the risk of sepsis as the main outcome; six of these studies showed a decreased risk of sepsis in patients receiving statins, whereas one study found no difference. CONCLUSIONS: The majority of the studies suggest that statins may have a positive role in the treatment of patients with sepsis and infection. However, the majority of the reviewed studies have the inherent methodological limitations of retrospective studies. Conclusions regarding this important clinical question should wait for the results of ongoing relevant randomized controlled trials.

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Crossref · 10.1093/jac/dkn019

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  • Meta-analyses and systematic reviews on statins and infection have yielded inconclusive results.

    “Moreover, a considerable number of meta-analyses and systematic reviews have examined the literature on statins and infection with rather inconclusive results (Falagas et al., 2008; Gao et al., 2008; Kopterides and Falagas, 2009; Tleyjeh et al., 2009, 2012; Bjorkhem-Bergman et al., 2010; Janda et al., 2010; van den Hoek et al., 2011; Ma et al., 2012; Wan et al., 2014; Wang et al., 2014).”

    From Atorvastatin Reduces the Survival of Candida albicans-Infected BALB/c Mice (2015) · cites this paper as Falagas et al., 2008

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Authors
Falagas, M. E., Makris, G. C., Matthaiou, D. K., & Rafailidis, P. I.
Affiliations
  • Tufts University (US)
  • Alfa Institute of Biomedical Sciences (GR)
Corresponding author
Falagas, M. E.
ORCID
Venue
Journal of Antimicrobial Chemotherapy
Publisher
Oxford University Press (OUP)
Published
2008-02-04
Volume
61
Issue
4
Pages
774-785
ISSN
  • 0305-7453 (ISSN-L)
  • 1460-2091
DOI
10.1093/jac/dkn019
OpenAlex
W2126287031
Cited by
166
References
30
Citations by year
2025: 6 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 12 · 2017: 5 · 2016: 8 · 2015: 11 · 2014: 16 · 2013: 10 · 2012: 15
FWCI
2.04
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Antimicrobial Chemotherapy (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
statins, sepsis, infection, community-acquired pneumonia, bacteremia, multiple organ failure, viral infection, bacterial infection, mortality, sepsis risk, immunomodulation
MeSH terms
Anti-Infective Agents, Bacterial Infections, Humans, Virus Diseases, Sepsis, Hydroxymethylglutaryl-CoA Reductase Inhibitors

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