Activity of novel antifungal compound APX001A against a large collection of Candida auris
Open accessAbstract
Background: APX001A is an antifungal agent that targets a novel pathway-glycosylphosphatidylinositol glycolipid biosynthesis. It has been shown to be effective against a variety of fungal species, including Candida spp., Aspergillus spp. and other filamentous fungi. Objectives: To determine the activity of APX001A against the emerging fungal pathogen Candida auris. Methods: APX001A was tested by broth microdilution against 100 geographically distinct isolates of C. auris. Results: APX001A showed activity against all isolates, including some that were resistant to one or more antifungals, with MIC50 and MIC90 of 0.002 and 0.008 mg/L, respectively. Conclusions: These findings suggest that APX001A shows encouraging activity against the emerging fungal pathogen C. auris.
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Surveillance studies have demonstrated that MGX was the most mycologically active agent against over 400 diverse C. auris isolates, including strains which were multi-drug resistant.
“Surveillance studies have demonstrated that MGX was the most mycologically active agent against over 400 diverse C. auris isolates, including strains which were multi-drug resistant (19, 20).”
From Clinical Efficacy and Safety of a Novel Antifungal, Fosmanogepix, in Patients with Candidemia Caused by Candida auris <i>:</i> Results from a Phase 2 Trial (2023) · cites this paper as [19]
Fosmanogepix inhibits inositol acyltransferase Gwt1, preventing GPI-anchored protein maturation, a process critical for linkages between fungal cell wall components.
“Fosmanogepix inhibits the inositol acyltransferase Gwt1 which catalyzes and early step in the glycosylphosphatidylinositol (GPI) anchor biosynthesis pathway, thereby preventing GPI-anchored protein maturation, a process critical for linkages between different components of the fungal cell wall [39,46].”
From Antifungal therapy of Candida biofilms: Past, present and future (2023) · cites this paper as [46]
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- Authors
- Berkow, E. L., & Lockhart, S. R.
- Affiliations
- Centers for Disease Control and Prevention (US)
- Corresponding author
- Berkow, Elizabeth L
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-08-01
- Volume
- 73
- Issue
- 11
- Pages
- 3060-3062
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2887248591
- Cited by
- 57
- References
- 12
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 6 · 2023: 10 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 9 · 2018: 2
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- Journal of Antimicrobial Chemotherapy (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- Candida auris, antifungal activity, glycosylphosphatidylinositol biosynthesis, emerging fungal pathogens, antifungal resistance, minimum inhibitory concentration
- MeSH terms
- Antifungal Agents, Candida, Microbial Sensitivity Tests, Drug Resistance, Multiple, Fungal
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