The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Involvement of partial EMT in cancer progression
Abstract
The epithelial-mesenchymal transition (EMT) provides an outstanding example of cellular plasticity during embryonic development and cancer progression. During EMT in embryonic development, epithelial cells lose all vestiges of their epithelial origin and acquire a fully mesenchymal phenotype, known as complete EMT, which is typically characterized by a so-called cadherin switch. Conversely, during EMT in cancer progression, cancer cells that originate from epithelial cells exhibit both mesenchymal and epithelial characteristics, that is the hybrid E/M phenotype in a process known as partial EMT. Partial EMT in cancer cells is thought to enhance their invasive properties, generate circulating tumour cells and cancer stem cells, and promote resistance to anti-cancer drugs. These phenotypic changes are regulated by extracellular matrix components, exosomes and soluble factors, which regulate several transcription factors known as EMT transcription factors. In this review, I summarize our current understanding of the EMT program during cancer progression.
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Applications of patient-derived tumor xenograft models and tumor organoids
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EMT and EndMT: Emerging Roles in Age-Related Macular Degeneration
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Epithelial-Mesenchymal Transition and Metastasis under the Control of Transforming Growth Factor β
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Pre-clinical Models of Metastasis in Pancreatic Cancer
Miquel, M., Zhang, S., & Pilarsky, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.748631 · Cited by 53
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Metadata
- Authors
- Saitoh, M.
- Venue
- The Journal of Biochemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-05-03
- Volume
- 164
- Issue
- 4
- Pages
- 257-264
- ISSN
- 0021-924X (ISSN-L)
- 1756-2651
- OpenAlex
- W2799898775
- Cited by
- 518
- References
- 55
- FWCI
- 15.33
- Type
- journal article
- Language
- en
- Open access
- closed
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